In vitro glucocorticoid sensitivity is associated with clinical glucocorticoid therapy outcome in rheumatoid arthritis

Arthritis Research and Therapy

Volumn 14, Issue 4, 2012, Pages

  Quax, Rogier A M ^a   Koper, Jan W ^a   de Jong, Pascal H P ^a   van Heerebeek, Ramona ^a   Weel, Angelique E ^b   Huisman, Anne M ^c   van Zeben, Derkjen ^c   de Jong, Frank H ^a   Lamberts, Steven W J ^a   Hazes, Johanna M W ^a   Feelders, Richard A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Maasstad Hospital   (Netherlands)

^c SINT FRANCISCUS GASTHUIS   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 2; LEUCINE ZIPPER PROTEIN; MESSENGER RNA; METHYLPREDNISOLONE; PREDNISONE; TRIAMCINOLONE ACETONIDE; GLUCOCORTICOID;

ADULT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE ACTIVITY; FEMALE; FOLLOW UP; GENE EXPRESSION; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROSPECTIVE STUDY; RECEPTOR BINDING; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME; AGED; ARTHRITIS, RHEUMATOID; CLINICAL TRIAL; COHORT ANALYSIS; MIDDLE AGED; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; AGED; ARTHRITIS, RHEUMATOID; COHORT STUDIES; FEMALE; GLUCOCORTICOIDS; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PREDNISONE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84865293339     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4029     Document Type: Article

References (44)

1. Chikanza LC, Panayi GS. The effects of hydrocortisone on in vitro lymphocyte proliferation and interleukin-2 and -4 production in corticosteroid sensitive and resistant subjects. Eur J Clin Invest 1993, 23:845-850. 10.1111/j.1365-2362.1993.tb00740.x, 8143761.
2. van Schaardenburg D, Valkema R, Dijkmans BA, Papapoulos S, Zwinderman AH, Han KH, Pauwels EK, Breedveld FC. Prednisone treatment of elderly-onset rheumatoid arthritis: disease activity and bone mass in comparison with chloroquine treatment. Arthritis Rheum 1995, 38:334-342. 10.1002/art.1780380307, 7880187.
3. Sliwinska-Stanczyk P, Pazdur J, Ziolkowska M, Jaworski J, Kaminska-Tchorzewska E, Lacki JK. The effect of methylprednisolone on proliferation of PBMCs obtained from steroid-sensitive and steroid-resistant rheumatoid arthritis patients. Scand J Rheumatol 2007, 36:167-171. 10.1080/03009740601154111, 17657668.
4. Manenschijn L, van den Akker EL, Lamberts SW, van Rossum EF. Clinical features associated with glucocorticoid receptor polymorphisms: an overview. Ann N Y Acad Sci 2009, 1179:179-198. 10.1111/j.1749-6632.2009.05013.x, 19906240.
5. van Oosten MJ, Dolhain RJ, Koper JW, van Rossum EF, Emonts M, Han KH, Wouters JM, Hazes JM, Lamberts SW, Feelders RA. Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis. Arthritis Res Ther 2010, 12:R159. 10.1186/ar3118, 2945062, 20727199.
6. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet 2009, 373:1905-1917. 10.1016/S0140-6736(09)60326-3, 19482216.
7. Sher ER, Leung DY, Surs W, Kam JC, Zieg G, Kamada AK, Szefler SJ. Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994, 93:33-39. 10.1172/JCI116963, 293719, 8282803.
8. Du J, Li M, Zhang D, Zhu X, Zhang W, Gu W, Feng Y, Zhai X, Ling C. Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther 2009, 11:R108. 10.1186/ar2763, 2745790, 19594946.
9. Gruber G, Carlet M, Turtscher E, Meister B, Irving JA, Ploner C, Kofler R. Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis. Leukemia 2009, 23:820-823.
10. Eggert M, Kluter A, Rusch D, Schmidt KL, Dotzlaw H, Schulz M, Pabst W, Boke J, Renkawitz R, Neeck G. Expression analysis of the glucocorticoid receptor and the nuclear factor-κB subunit p50 in lymphocytes from patients with rheumatoid arthritis. J Rheumatol 2002, 29:2500-2506.
11. Huisman AM, Siewertsz van Everdingen AA, Wenting MJ, Lafeber F, van Reesema DR, Jacobs JW, Bijlsma JW. Glucocorticoid receptor up-regulation in early rheumatoid arthritis treated with low dose prednisone or placebo. Clin Exp Rheumatol 2003, 21:217-220.
12. Huisman AM, Van Everdingen AA, Wenting MJ, Siewertsz Van Reesema DR, Lafeber FP, Jacobs JW, Bijlsma JW. Glucocorticoid receptor downregulation in early diagnosed rheumatoid arthritis. Ann N Y Acad Sci 2002, 966:64-67. 10.1111/j.1749-6632.2002.tb04202.x, 12114259.
13. Schlaghecke R, Kornely E, Wollenhaupt J, Specker C. Glucocorticoid receptors in rheumatoid arthritis. Arthritis Rheum 1992, 35:740-744. 10.1002/art.1780350704, 1622411.
14. Hearing SD, Norman M, Probert CS, Haslam N, Dayan CM. Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes. Gut 1999, 45:382-388. 10.1136/gut.45.3.382, 1727659, 10446106.
15. Corrigan CJ, Brown PH, Barnes NC, Szefler SJ, Tsai JJ, Frew AJ, Kay AB. Glucocorticoid resistance in chronic asthma: glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Respir Dis 1991, 144:1016-1025. 10.1164/ajrccm/144.5.1016, 1952426.
16. Kirkham BW, Corkill MM, Davison SC, Panayi GS. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses. J Rheumatol 1991, 18:821-825.
17. Smit P, Russcher H, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW. Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2. J Clin Endocrinol Metab 2005, 90:2994-3000. 10.1210/jc.2004-2298, 15728202.
18. Cannarile L, Zollo O, D'Adamio F, Ayroldi E, Marchetti C, Tabilio A, Bruscoli S, Riccardi C. Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene. Cell Death Differ 2001, 8:201-203. 10.1038/sj.cdd.4400798, 11313722.
19. Vacca A, Martinotti S, Screpanti I, Maroder M, Felli MP, Farina AR, Gismondi A, Santoni A, Frati L, Gulino A. Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones: role of steroid receptor and antigen-responsive 5'-flanking sequences. J Biol Chem 1990, 265:8075-8080.
20. Claessen SJ, Hazes JM, Huisman MA, van Zeben D, Luime JJ, Weel AE. Use of risk stratification to target therapies in patients with recent onset arthritis; design of a prospective randomized multicenter controlled trial. BMC Musculoskel Disord 2009, 10:71.
21. Visser H, le Cessie S, Vos K, Breedveld FC, Hazes JM. How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002, 46:357-365. 10.1002/art.10117, 11840437.
22. Bingham CO, Pohl C, Woodworth TG, Hewlett SE, May JE, Rahman MU, Witter JP, Furst DE, Strand CV, Boers M, Alten RE. Developing a standardized definition for disease "flare" in rheumatoid arthritis (OMERACT 9 Special Interest Group). J Rheumatol 2009, 36:2335-2341. 10.3899/jrheum.090369, 19684147.
23. Molijn GJ, Koper JW, van Uffelen CJ, de Jong FH, Brinkmann AO, Bruining HA, Lamberts SW. Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock. Clin Endocrinol (Oxf) 1995, 43:197-203.
24. Bruce B, Fries JF. The Stanford Health Assessment Questionnaire: a review of its history, issues, progress, and documentation. J Rheumatol 2003, 30:167-178.
25. Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol 2011, 335:2-13. 10.1016/j.mce.2010.04.005, 3047790, 20398732.
26. Chikanza IC, Petrou P, Kingsley G, Chrousos G, Panayi GS. Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 1992, 35:1281-1288.
27. Silverman MN, Sternberg EM. Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance. Neuroimmunomodulation 2008, 15:19-28. 2920141, 18667796.
28. Clark AR. Anti-inflammatory functions of glucocorticoid-induced genes. Mol Cell Endocrinol 2007, 275:79-97. 10.1016/j.mce.2007.04.013, 17561338.
29. Mittelstadt PR, Ashwell JD. Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J Biol Chem 2001, 276:29603-29610. 10.1074/jbc.M101522200, 11397794.
30. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Blood 2001, 98:743-753. 10.1182/blood.V98.3.743, 11468175.
31. Beaulieu E, Ngo D, Santos L, Yang YH, Smith M, Jorgensen C, Escriou V, Scherman D, Courties G, Apparailly F, Morand EF. Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis. Arthritis Rheum 2010, 62:2651-2661. 10.1002/art.27566, 20496421.
32. Cannarile L, Cuzzocrea S, Santucci L, Agostini M, Mazzon E, Esposito E, Muia C, Coppo M, Di Paola R, Riccardi C. Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis. Gastroenterology 2009, 136:530-541. 10.1053/j.gastro.2008.09.024, 18996377.
33. De Antonio SR, Saber LT, Chriguer RS, de Castro M. Glucocorticoid resistance in dialysis patients may impair the kidney allograft outcome. Nephrol Dial Transplant 2008, 23:1422-1428.
34. Schlechte JA, Ginsberg BH, Sherman BM. Regulation of the glucocorticoid receptor in human lymphocytes. J Steroid Biochem 1982, 16:69-74. 10.1016/0022-4731(82)90145-5, 7062741.
35. Perisic T, Sreckovic M, Matic G. Modulation of glucocorticoid receptor function and expression in adolescent moderate asthma. Respiration 2009, 77:70-75. 10.1159/000156959, 18799869.
36. Elakovic I, Perisic T, Cankovic-Kadijevic M, Matic G. Correlation between glucocorticoid receptor binding parameters, blood pressure, and body mass index in a healthy human population. Cell Biochem Funct 2007, 25:427-431. 10.1002/cbf.1323, 16615046.
37. Schlechte JA, Sherman BM. Decreased glucocorticoid receptor binding in adrenal insufficiency. J Clin Endocrinol Metab 1982, 54:145-149. 10.1210/jcem-54-1-145, 7054210.
38. Magee MH, Blum RA, Lates CD, Jusko WJ. Pharmacokinetic/pharmacodynamic model for prednisolone inhibition of whole blood lymphocyte proliferation. Br J Clin Pharmacol 2002, 53:474-484. 10.1046/j.1365-2125.2002.01567.x, 1874371, 11994053.
39. Dasgupta B, Gray J, Fernandes L, Olliff C. Treatment of polymyalgia rheumatica with intramuscular injections of depot methylprednisolone. Ann Rheum Dis 1991, 50:942-945. 10.1136/ard.50.12.942, 1004588, 1768166.
40. Limbourg FP, Liao JK. Nontranscriptional actions of the glucocorticoid receptor. J Mol Med 2003, 81:168-174. 2649714, 12682725.
41. Smith MD, Ahern MJ, Brooks PM, Roberts-Thomson PJ. The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid arthritis. II. Effects on immune and inflammatory indices in peripheral blood. J Rheumatol 1988, 15:233-237.
42. van der Linden MP, le Cessie S, Raza K, van der Woude D, Knevel R, Huizinga TW, van der Helm-van Mil AH. Long-term impact of delay in assessment of patients with early arthritis. Arthritis Rheum 2010, 62:3537-3546. 10.1002/art.27692, 20722031.
43. Edwards C. Sixty years after hench: corticosteroids and chronic inflammatory disease. J Clin Endocrinol Metab 2012, 97:1443-1451. 10.1210/jc.2011-2879, 22378812.
44. Hardy R, Rabbitt EH, Filer A, Emery P, Hewison M, Stewart PM, Gittoes NJ, Buckley CD, Raza K, Cooper MS. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis 2008, 67:1204-1210. 2564803, 18420938.