Concurrent emergence of multidrug resistance and heat resistance by CTX-M-15-encoding conjugative plasmids in Klebsiella pneumoniae

APMIS

Volumn 120, Issue 9, 2012, Pages 699-705

  Bojer, Martin S ^a,b   Hammerum, Anette M ^a   Jørgensen, Steffen L ^a   Hansen, Frank ^a   Olsen, Stefan S ^a   Krogfelt, Karen A ^a   Struve, Carsten ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b ROSKILDE UNIVERSITY   (Denmark)

Author keywords

Conjugative co transfer; ESBL; Heat resistance; K. pneumoniae

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM COLONY; BACTERIUM CONJUGATION; BACTERIUM ISOLATE; BLOODSTREAM INFECTION; CLONE; CLPK GENE; CONTROLLED STUDY; DENMARK; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ENTEROBACTERIACEAE; GENE; GENE LOCATION; HEAT TOLERANCE; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL;

BETA-LACTAMASES; CONJUGATION, GENETIC; DENMARK; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; NUCLEIC ACID HYBRIDIZATION; PLASMIDS; RETROSPECTIVE STUDIES;

EID: 84865290791     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2012.02885.x     Document Type: Article

References (23)

1. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998;11:589-603.
2. Yu VL, Hansen DS, Ko WC, Sagnimeni A, Klugman KP, von Gottberg A, et al. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis 2007;13:986-93.
3. Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, et al. CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother 2007;59:165-74.
4. Peirano G, Pitout JD. Molecular epidemiology of Escherichia coli producing CTX-M beta-lactamases: the worldwide emergence of clone ST131 O25:H4. Int J Antimicrob Agents 2010;35:316-21.
5. Valverde A, Coque TM, García-San Miguel L, Baquero F, Cantón R. Complex molecular epidemiology of extended-spectrum beta-lactamases in Klebsiella pneumoniae: a long-term perspective from a single institution in Madrid. J Antimicrob Chemother 2008;61:64-72.
6. Oteo J, Cuevas O, López-Rodríguez I, Banderas-Florido A, Vindel A, Pérez-Vázquez M, et al. Emergence of CTX-M-15-producing Klebsiella pneumoniae of multilocus sequence types 1, 11, 14, 17, 20, 35 and 36 as pathogens and colonizers in newborns and adults. J Antimicrob Chemother 2009;64:524-8.
7. Lee MY, Ko KS, Kang C-I, Chung DR, Peck KR, Song JH. High prevalence of CTX-M-15-producing Klebsiella pneumoniae isolates in Asian countries: diverse clones and clonal dissemination. Int J Antimicrob Agents 2011;38:160-3.
8. Damjanova I, Tóth A, Pászti J, Hajbel-Vékony G, Jakab M, Berta J, et al. Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005 - the new 'MRSAs'? J Antimicrob Chemother 2008;62:978-85.
9. Lester CH, Olsen SS, Jakobsen L, Arpi M, Fuursted K, Hansen DS, et al. Emergence of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae in Danish hospitals; this is in part explained by spread of two CTX-M-15 clones with multilocus sequence types 15 and 16 in Zealand. Int J Antimicrob Agents 2011;38:180-2.
10. Bojer MS, Struve C, Ingmer H, Hansen DS, Krogfelt KA. Heat resistance mediated by a new plasmid encoded Clp ATPase, ClpK, as a possible novel mechanism for nosocomial persistence of Klebsiella pneumoniae. PLoS ONE 2010;5:e15467.
11. Bojer MS, Krogfelt KA, Struve C. The newly discovered ClpK protein strongly promotes survival of Klebsiella pneumoniae biofilm subjected to heat shock. J Med Microbiol 2011;60:1559-61.
12. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 1.3, January 2011. Available at: http://www.eucast.org/clinical_breakpoints/.
13. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 2005;63:219-28.
14. Villa L, García-Fernandez A, Fortini D, Carattoli A. Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants. J Antimicrob Chemother 2010;65:2518-29.
15. BLAST. Basic Local Alignment Tool. Available at: http://www.ncbi.nlm.nih.gov/blast (accessed 19 October 2011).
16. Lytsy B, Sandegren L, Tano E, Torell E, Andersson DI, Melhus A. The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15. APMIS 2008;116:302-8.
17. KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain. J Antimicrob Chemother 2010;65:1608-14.
18. Coelho A, González-López JJ, Miró E, Alonso-Tarrés C, Mirelis B, Larrosa MN, et al. Characterisation of the CTX-M-15-encoding gene in Klebsiella pneumoniae strains from the Barcelona metropolitan area: plasmid diversity and chromosomal integration. Int J Antimicrob Agents 2010;36:73-78.
19. Coelho A, Mirelis B, Alonso-Tarrés C, Nieves Larrosa M, Miró E, Clivillé Abad R, et al. Detection of three stable genetic clones of CTX-M-15-producing Klebsiella pneumoniae in the Barcelona metropolitan area, Spain. J Antimicrob Chemother 2009;64:862-4.
20. Schjørring S, Struve C, Krogfelt KA. Transfer of antimicrobial resistance plasmids from Klebsiella pneumoniae to Escherichia coli in the mouse intestine. J Antimicrob Chemother 2008;62:1086-93.
21. Gundogan N, Citak S, Yalcin E. Virulence properties of extended spectrum β-lactamase-producing Klebsiella species in meat samples. J Food Prot 2011;74:559-64.
22. Calbo E, Freixas N, Xercavins M, Riera M, Nicolás C, Monistrol O, et al. Foodborne nosocomial outbreak of SHV1 and CTX-M-15-producing Klebsiella pneumoniae: epidemiology and control. Clin Infect Dis 2011;52:743-9.
23. Sandegren L, Linkevicius M, Lytsy B, Melhus A, Andersson DI. Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak. J Antimicrob Chemother 2012;67:74-83.