Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: Potential implications

Thrombosis Journal

Volumn 10, Issue , 2012, Pages

  Said, Rose ^a,b   Regnault, Véronique ^a,b   Hacquard, Marie ^a,c   Carteaux, Jean Pierre ^a   Lecompte, Thomas ^a,b,c  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b INSERM   (France)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

Cardio pulmonary bypass; Platelets; Thrombin; Thrombography

Indexed keywords

THROMBIN;

ADULT; AGED; ANGIOGRAPHY; AORTA VALVE REPLACEMENT; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CALIBRATED AUTOMATED THROMBOGRAPHY; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; FEMALE; HUMAN; IN VITRO STUDY; LOW RISK POPULATION; MALE; MITRAL VALVE REPLACEMENT; STATISTICAL SIGNIFICANCE; THROMBIN TIME; THROMBOCYTE; THROMBOCYTE DYSFUNCTION;

EID: 84865287210     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/1477-9560-10-15     Document Type: Article

References (18)

1. Bevan DH. Cardiac bypass haemostasis: putting blood through the mill. Br J Haemato 1999, l104:208-219.
2. Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood 1990, 76:1680-97.
3. Lecompte T, Hacquard M, Carteaux JP. Eptacog-alpha (activated) aka human clotting factor VII recombinant and activated, in cardiac surgery with cardiopulmonary by pass: where do we stand in 2006?. ITBM-RBM 2006, 27:S35-S39.
4. Weerwind PW, Lindhout T, Caberg NE, De Jong DS. Thrombin generation during cardiopulmonary bypass: the possible role of retransfusion of blood aspirated from the surgical field. Thromb J 2003, 1(1):3. 179879, 12904260.
5. Trossaërt M, Regnault V, Sigaud M, Boisseau P, Fressinaud E, Lecompte T. Mild hemophilia A with factor VIII assay discrepancy: using thrombin generation assay to assess the bleeding phenotype. J Thromb Haemost 2008, 6(3):486-493. 10.1111/j.1538-7836.2007.02861.x, 18047548.
6. Schols SE, Feijge MA, Lancé MD, Hamulyák K, ten Cate H, Heemskerk JW, van Pampus EC. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery. Thromb Haemost 2010, 103:318-328.
7. Solomon C, Rahe-Meyer N, Sørensen B. Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery. Thromb Res 2011, 128:277-827. 10.1016/j.thromres.2011.02.022, 21429567.
8. Coakley M, Hall JE, Evans C, Duff E, Billing V, Yang L, McPherson D, Stephens E, Macartney N, Wilkes AR, Collins PW. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. J Thromb Haemost 2011, 9:282-292. 10.1111/j.1538-7836.2010.04146.x, 21091865.
9. The Subcommittee on Control of Anticoagulation of the SSC of the ISTH Towards a recommendation for the standardization of the measurement of platelet-dependent thrombin generation. J Thromb Haemost 2011, 9:1859-61. The Subcommittee on Control of Anticoagulation of the SSC of the ISTH.
10. Hemker HC, Giesen P, Al Dieri R, Regnault V, de Smedt E, Wagenvoord R, Lecompte S, Béguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003, 33(1):4-15. 10.1159/000071636, 12853707.
11. Flaujac C, Pouard P, Boutouyrie P, Emmerich J, Bachelot-Loza C, Lasne D. Platelet dysfunction after normothermic cardiopulmonary bypass in children: effect of high-dose aprotonin. Thromb Haemost 2007, 98:385-391.
12. Pumphrey CW, Dawes J. Platelet alpha granule depletion: findings in patients with prosthetic heart valves and following cardiopulmonary bypass surgery. Thromb Res 1983, 30:257-64. 10.1016/0049-3848(83)90079-8, 6191404.
13. Lecompte T, Carteaux JP, Regnault V, de Maistre E, Collet JY, JP V. Is it possible and worth to use another anticoagulant than (unfractionated) heparin during cardiopulmonary bypass for cardiac surgery?. ITBM-RBM 2003, 24:S35-S39.
14. Blome M, Isgro F, Kiessling AH, Skuras J, Haubelt H, Hellstern P, Saggau W. Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery. Thromb Haemost 2005, 93:1101-7.
15. Prisco D, Paniccia R. Point-of-care: testing of hemostasis in cardiac surgery. Thromb J 2003, 1(1):1. 166118, 12904262.
16. Reverter JC, Béguin S, Kessels H, Kumar R, Hemker HC, Coller BS. Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7e3 antibody. potential implications for the effect of c7E3 Fab treatment on acute thrombosis and " Clinical Restenosis" J Clin Invest 1996, 98:863-874. 10.1172/JCI118859, 507497, 8698879.
17. Nieuwland R, Berckmans RJ, Rotteveel-Eijkman RC, Maquelin KN, Roozendaal KJ, Jansen PG, ten Have K, Eijsman L, Hack CE, Sturk A. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation 1997, 96:3534-41. 10.1161/01.CIR.96.10.3534, 9396452.
18. Schols SE, Feijge MA, Lancé MD, Hamulyák K, ten Cate H, Heemskerk JW, van Pampus EC. Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography partly compensating role of platelets. Transfusion 2008, 48:2384-2394. 10.1111/j.1537-2995.2008.01872.x, 18673348.