FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

Molecular and Cellular Endocrinology

Volumn 362, Issue 1-2, 2012, Pages 69-75

  Hoekstra, Menno ^a   van der Sluis, Ronald J ^a   Li, Zhaosha ^a   Oosterveer, Maaike H ^b   Groen, Albert K ^b   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Cholesterol; Corticosterone; FXR; Glucocorticoid; GW4064; SR BI

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; CHOLESTEROL; CORTICOSTERONE; CORTICOTROPIN; MESSENGER RNA; SCAVENGER RECEPTOR BI; TRIACYLGLYCEROL;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DRUG EFFECT; FEMALE; GENE EXPRESSION; IMMUNOBLOTTING; LIPID ANALYSIS; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; APOLIPOPROTEINS A; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORTICOSTERONE; FEMALE; GLUCOCORTICOIDS; ISOXAZOLES; LIPID METABOLISM; LIPIDS; LIVER; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PROGESTERONE REDUCTASE; RECEPTOR, MELANOCORTIN, TYPE 2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SCAVENGER RECEPTORS, CLASS B; STEROID 11-BETA-HYDROXYLASE; STEROID 21-HYDROXYLASE; TRYPTOPHAN OXYGENASE;

EID: 84865283034     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.05.010     Document Type: Article

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