Fibrin clot structure and fibrinolysis in hypothyroid individuals: The effects of normalising thyroid hormone levels

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 8, 2012, Pages 1708-1710

  Stuijver, D J F ^a,b   Hooper, J M W ^c   Orme, S M ^c   Van Zaane, B ^a,b   Squizzato, A ^d   Piantanida, E ^d   Hess, K ^e   Alzahrani, S ^c   Ajjan, R A ^c  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; LEVOTHYROXINE; THYROID HORMONE; THYROTROPIN;

BODY MASS; CONFOCAL MICROSCOPY; DISEASE ASSOCIATION; DYSLIPIDEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBRIN CLOT; FIBRINOLYSIS; FOLLOW UP; HUMAN; HYPERTENSION; HYPERTHYROIDISM; HYPOTHYROIDISM; LETTER; PRIORITY JOURNAL; THROMBOSIS; THYROID FUNCTION TEST; TURBIDIMETRY; WEIGHT GAIN;

ANIMALS; BLOOD COAGULATION; HUMANS; PARTIAL THROMBOPLASTIN TIME; THROMBIN;

EID: 84865277261     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2012.04789.x     Document Type: Letter

References (9)

1. Squizzato A, Romualdi E, Buller HR, Gerdes VE. Clinical review: thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review. J Clin Endocrinol Metab 2007; 92: 2415-20.
2. Ajjan R, Lim BC, Standeven KF, Harrand R, Dolling S, Phoenix F, Greaves R, Abou-Saleh RH, Connell S, Smith DA, Weisel JW, Grant PJ, Ariens RA. Common variation in the C-terminal region of the fibrinogen beta-chain: effects on fibrin structure, fibrinolysis and clot rigidity. Blood 2008; 111: 643-50.
3. Hooper JM, Stuijver DJ, Orme SM, van Zaane B, Hess K, Gerdes VE, Phoenix F, Rice P, Smith KA, Alzahrani SH, Standeven KF, Ajjan RA. Thyroid dysfunction and fibrin network structure: a mechanism for increased thrombotic risk in hyperthyroid individuals. J Clin Endocrinol Metab 2012; 97: 1463-73.
4. Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 2001; 344: 501-9.
5. Roberts CG, Ladenson PW. Hypothyroidism. Lancet 2003; 363: 793-803.
6. Carter AM, Cymbalista CM, Spector TD, Grant PJ. Heritability of clot formation, morphology, and lysis: the EuroCLOT study. Arterioscler Thromb Vasc Biol 2007; 27: 2783-9.
7. Mills JD, Ariens RA, Mansfield MW, Grant PJ. Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease. Circulation 2002; 106:1938-42.
8. Collet JP, Allali Y, Lesty C, Tanguy ML, Silvain J, Ankri A, Blanchet B, Dumaine R, Gianetti J, Payot L, Weisel JW, Montalescot G. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol 2006; 26: 2567-73.
9. Undas A, Szuldrzynski K, Stepien E, Zalewski J, Godlewski J, Tracz W, Pasowicz M, Zmudka K. Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress. Atherosclerosis 2008; 196: 551-7.