Group sequential and adaptive designs - A review of basic concepts and points of discussion

Biometrical Journal

Volumn 50, Issue 4, 2008, Pages 541-557

  Vandemeulebroecke, Marc ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Adaptive design; Combination test; Conditional error function; Flexible design; Group sequential design; Interim analysis; Sequential analysis; Spending function; Trial integrity; Trial validity

Indexed keywords

ADAPTIVE DESIGNS; COMBINATION TEST; CONDITIONAL ERROR FUNCTION; ERROR-FUNCTION; FLEXIBLE DESIGNS; GROUP SEQUENTIAL DESIGN; INTERIM ANALYSIS; SEQUENTIAL ANALYSIS; SEQUENTIAL DESIGN; SPENDING FUNCTION; TRIAL INTEGRITY; TRIAL VALIDITY;

EID: 54349106124     PISSN: 03233847     EISSN: 15214036     Source Type: Journal    
DOI: 10.1002/bimj.200710436     Document Type: Review

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