Possible mechanisms of action of the aqueous extract of Artocarpus altilis (breadfruit) leaves in producing hypotension in normotensive SpragueDawley rats

Pharmaceutical Biology

Volumn 50, Issue 9, 2012, Pages 1096-1102

  Nwokocha, Chukwuemeka R ^a   Owu, Daniel U ^a   McLaren, Michca ^a   Murray, Jeann ^a   Delgoda, Rupika ^a   Thaxter, Karen ^a   McCalla, Garsha ^a   Young, Lauriann ^a  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

Author keywords

Blood pressure; Ca2+ antagonisim; CYP; Cytochrome P450; Hypotension; Mechanism of action

Indexed keywords

ANTIHYPERTENSIVE AGENT; ARTOCARPUS ALTILIS EXTRACT; CYTOCHROME P450; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CHRONOTROPISM; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; HEART RATE VARIABILITY; MALE; MEAN ARTERIAL PRESSURE; MICROSOME; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; SPRAGUE DAWLEY RAT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; ARTOCARPUS; ARYL HYDROCARBON HYDROXYLASES; CALCIUM CHANNEL BLOCKERS; CYTOCHROME P-450 CYP2D6; ENZYME INHIBITORS; ETHNOPHARMACOLOGY; HUMANS; JAMAICA; MALE; MUSCLE, SMOOTH, VASCULAR; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; VASODILATOR AGENTS;

EID: 84865265541     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.658113     Document Type: Article

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