Efficiency by design: Optimisation in process research

Organic Process Research and Development

Volumn 5, Issue 3, 2001, Pages 308-323

  Owen, Martin R ^a   Luscombe, Chris ^a   Lai, Lai Wah ^a   Godbert, Sonya ^a   Crookes, Derek L ^a   Emiabata Smith, David ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035533034     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op000024q     Document Type: Article

References (14)

1. Box, G. E. P.; Hunter, W. G.; Hunter, J. S. Statistics for Experimenters; Wiley: New York, 1978.
2. Carlson, R. Design and Optimisation in Organic Synthesis; Elsevier: Amsterdam, 1992.
3. There are many commercially available DOE packages. The software package we used was Design-Expert 5 (DX-5) (http://www.statease.com).
4. Ghiron, C.; Rossi, T. The Chemistry of Trinems. Targets Heterocycl. Syst. 1997, 1, 161-186.
5. Franz, R. J. Fluorine Chem. 1980, 15, 423; McClinton, M. A. Aldrichimica Acta 1995, 28(2), 31.
6. Franz, R. J. Fluorine Chem. 1980, 15, 423; McClinton, M. A. Aldrichimica Acta 1995, 28(2), 31.
7. The Gilson 231XL and the Peltier block are commercially available from Anachem Ltd, Charles Street, Luton, Beds, LU2 OEB UK.
8. Far Research Inc., 307 Amherst Road, PO Box 2278. Morganton, NC 28680, U.S.A., Telephone: 704 438 0101.
9. Owen, M. R. Laboratory Automation in Chemical Development. In Process Chemistry in the Pharmaceutical Industry; Gadamasetti, K., Ed.; Marcel Dekker Inc.: New York, 1998; pp 429-455.
10. For example: Josses, P. Adv. Lab. Autom. Rob. 1989, 6, 463-475.
11. Fujita, T.; Umemura, S.; Uchida, N. Jpn. Kokai Tokkyo. Patent Application JP 92-128553 920521.
12. Emiabata-Smith, D. F.; Crookes, D.; Owen, M. R. Org. Process Res. Dev. 1999, 3, 281-288.
13. Owen, M. R.; Smith, L. C. Presented at the 3rd Laboratoratory Automation in Process R&D Symposium, Boston, 2000.
14. The Anachem SK233 Workstation (formally referred to as the DART system, during its development at GlaxoWellcome) is commercially available from Anachem Ltd, Charles Street, Luton, Beds, LU2 OEB UK.