Aggregation of gold nanoparticles followed by methotrexate release enables Raman imaging of drug delivery into cancer cells

Journal of Nanoparticle Research

Volumn 14, Issue 9, 2012, Pages

  Durgadas, C V ^a   Sharma, C P ^a   Paul, W ^a   Rekha, M R ^a   Sreenivasan, K ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Gold nanoparticle; HepG2 cells; Methotrexate; Raman imaging; Targeted drug delivery

Indexed keywords

BIOCOMPATIBILITY; CONTROLLED DRUG DELIVERY; FIBER OPTIC SENSORS; GOLD NANOPARTICLES; METAL NANOPARTICLES; RAMAN SPECTROSCOPY; SYNTHESIS (CHEMICAL);

CELLULAR COMPONENTS; CELLULAR INTERNALIZATION; GOLD NANOPARTICLES (GNPS); HEP-G2 CELLS; METHOTREXATE; METHOTREXATE (MTX); RAMAN IMAGING; SITE-SPECIFIC DRUG DELIVERIES;

TARGETED DRUG DELIVERY;

COPOLYMER; GOLD NANOPARTICLE; METHOTREXATE;

ARTICLE; CANCER CELL; CELL STRAIN HEPG2; DRUG DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAMAN SPECTROMETRY;

EID: 84865252131     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-012-1127-7     Document Type: Article

References (34)

1. Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD (2009) Cellular uptake and cytotoxicity of gold nanorods: Molecular origin of cytotoxicity and surface effects. Small 5(6):701-708. doi:10.1002/smll.200801546
2. Bruce NC (1997) The mechanism of action of methotrexate. Rheum Dis Clin N Am23(4):739-755. doi:10.1016/s0889-857x(05)70358-6
3. Brust M, Walker M, Bethell D, Schiffrin DJ, Whyman R (1994) Synthesis of thiol-derivatised gold nanoparticles in a twophase liquid-liquid system. J Chem Soc Chem Commun 7: 801-802
4. Chen Y-H, Tsai C-Y, Huang P-Y, Chang M-Y, Cheng P-C, Chou C-H, Chen D-H, Wang C-R, Shiau A-L, Wu C-L (2007) Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm 4(5):713-722. doi:10.1021/mp060132k (Pubitemid 350004271)
5. Chithrani DB, Dunne M, Stewart J, Allen C, Jaffray DA (2010) Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. Nanomed Nanotechnol Biol Med 6(1):161-169. doi:10.1016/j.nano.2009.04.009
6. Dasary SSR, Singh AK, Senapati D, Yu H, Ray PC (2009) Gold nanoparticle based label-free SERS probe for ultrasensitive and selective detection of trinitrotoluene. J Am Chem Soc 131(38):13806-13812. doi:10.1021/ja905134d
7. Day ES, Morton JG, West JL (2009) Nanoparticles for thermal cancer therapy. J Biomech Eng 131(7):074001
8. Duncan B, Kim C, Rotello VM (2010) Gold nanoparticle platforms as drug and biomacromolecule delivery systems. J Control Release 148(1):122-127. doi:10.1016/j.jconrel. 2010.06.004
9. El-Sayed IH, Huang X, El-Sayed MA (2005) Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer. Nano Lett 5(5):829-834. doi: 10.1021/nl050074e (Pubitemid 40749040)
10. Fang C, Bhattarai N, Sun C, Zhang M (2009) Functionalized nanoparticles with long-term stability in biological media. Small 5(14):1637-1641. doi:10.1002/smll.200801647
11. Galanzha EI, Shashkov EV, Kelly T, Kim J-W, Yang L, Zharov VP (2009) In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells. Nat Nano 4(12):855-860. http://www.nature.com/nnano/journal/ v4/n12/suppinfo/nnano.2009.333-S1.html
12. Gomez S, Philippot K, Colliere V, Chaudret B, Senocq F, Lecante P (2000) Gold nanoparticles from self-assembled gold(I) amine precursors. Chem Commun 19:1945-1946
13. He H, Xie C, Ren J (2008) Nonbleaching fluorescence of gold nanoparticles and its applications in cancer cell imaging. Anal Chem 80(15):5951-5957. doi:10.1021/ac8005796
14. Huang C-C, Yang Z, Lee K-H, Chang H-T (2007) Synthesis of highly fluorescent gold nanoparticles for sensing mercury (II). Angew Chem 119(36):6948-6952. doi:10.1002/ange. 200700803
15. Huang C-C, Chen C-T, Shiang Y-C, Lin Z-H, Chang H-T (2009) Synthesis of fluorescent carbohydrate-protected au nanodots for detection of concanavalin A and Escherichia coli. Anal Chem 81(3):875-882. doi:10.1021/ac8010654
16. Hussain I, Graham S, Wang Z, Tan B, Sherrington DC, Rannard SP, Cooper AI, BrustM(2005) Size-controlled synthesis of near-monodisperse gold nanoparticles in the 1-4 nm range using polymeric stabilizers. J Am Chem Soc 127(47): 16398-16399. doi:10.1021/ja055321v (Pubitemid 41740382)
17. Jain NK, Gupta U (2008) Application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability. Expert Opin Drug Metab Toxicol 4(8): 1035-1052. doi:10.1517/17425255.4.8.1035
18. Kneipp J, Kneipp H, Rice WL, Kneipp K (2005) Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold nanoparticles. Anal Chem 77(8):2381-2385. doi:10.1021/ac050 109v (Pubitemid 40562737)
19. Kohler N, Sun C, Wang J, Zhang M (2005) Methotrexatemodified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. Langmuir 21(19):8858-8864. doi:10.1021/la0503451 (Pubitemid 41396647)
20. Lee S, Kim S, Choo J, Shin SY, Lee YH, Choi HY, Ha S, Kang K, Oh CH (2007) Biological imaging of HEK293 cells expressing PLCc1 using surface-enhanced Raman microscopy. Anal Chem 79(3):916-922. doi:10.1021/ ac061246a
21. Leff DV, Brandt L, Heath JR (1996) Synthesis and characterization of hydrophobic, organically-soluble gold nanocrystals functionalized with primary amines. Langmuir 12(20): 4723-4730. doi:10.1021/la960445u (Pubitemid 126568002)
22. Liu Y, Shipton MK, Ryan J, Kaufman ED, Franzen S, Feldheim DL (2007) Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers. Anal Chem 79(6):2221-2229. doi:10.1021/ac061578f (Pubitemid 46449000)
23. Louit G, Asahi T, Tanaka G, Uwada T, Masuhara H (2009) Spectral and 3-dimensional tracking of single gold nanoparticles in living cells studied by Rayleigh light scattering microscopy. J Phys Chem C 113(27):11766-11772. doi: 10.1021/jp9018124
24. Lu A-H, Salabas EL, Schuth F (2007) Magnetic nanoparticles: Synthesis, protection, functionalization, and application. Angew Chem Int Ed 46(8):1222-1244. doi:10.1002/anie.2006 02866
25. Medley CD, Smith JE, Tang Z, Wu Y, Bamrungsap S, Tan W (2008) Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal Chem 80(4): 1067-1072. doi:10.1021/ac702037y (Pubitemid 351272339)
26. Murday JS, Siegel RW, Stein J, Wright JF (2009) Translational nanomedicine: Status assessment and opportunities. Nanomedicine 5(3):251-273. doi:10.1016/j.nano.2009.06. 001
27. Murphy CJ, Gole AM, Stone JW, Sisco PN, Alkilany AM, Goldsmith EC, Baxter SC (2008) Gold nanoparticles in biology: Beyond toxicity to cellular imaging. Acc Chem Res 41(12):1721-1730. doi:10.1021/ar800035u
28. Riehemann K, Schneider SW, Luger TA, Godin B, Ferrari M, Fuchs H (2009) Nanomedicine: Challenge and perspectives. Angew Chem Int Ed 48(5):872-897. doi:10.1002/ anie.200802585
29. Saar BG, Contreras-Rojas LR, Xie XS, Guy RH (2011) Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharm 8(3):969-975. doi:10.1021/mp200 122w
30. Shah NB, Dong J, Bischof JC (2010) Cellular uptake and nanoscale localization of gold nanoparticles in cancer using label-free confocal Raman microscopy. Mol Pharm 8(1):176-184. doi:10.1021/mp1002587
31. Shimmin RG, Schoch AB, Braun PV (2004) Polymer size and concentration effects on the size of gold nanoparticles capped by polymeric thiols. Langmuir 20(13):5613-5620. doi:10.1021/la036365p
32. Templeton AC, Pietron JJ, Murray RW, Mulvaney P (1999) Solvent refractive index and core charge influences on the surface plasmon absorbance of alkanethiolate monolayerprotected gold clusters. J Phys Chem B 104(3):564-570. doi:10.1021/jp991889c
33. Xie J, Xu C, Kohler N, Hou Y, Sun S (2007) Controlled PEGylation of monodisperse Fe3O4 nanoparticles for reduced non-specific uptake bymacrophage cells.Adv Mater 19(20): 3163-3166. doi:10.1002/adma.200701975 (Pubitemid 350044454)
34. Zamboni WC (2008) Concept and clinical evaluation of carriermediated anticancer agents. Oncologist 13(3):248-260. doi:10.1634/theoncologist.2007-0180 (Pubitemid 351679900)