Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 29054-29061

  Xu, Yongmei ^a   Pempe, Elizabeth H ^a   Liu, Jian ^a  

^a University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY MEASUREMENTS; ANTI-COAGULANT DRUGS; BLOOD CLOT FORMATION; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC APPROACHES; GLYCOSYLTRANSFERASES; HEPARAN SULFATES; PLATELET FACTOR-4; STRUCTURE AND FUNCTION RELATIONSHIP; SULFATED POLYSACCHARIDES; THROMBOCYTOPENIA;

ENZYMES; HYDRAULIC STRUCTURES; POLYSACCHARIDES; PROBES;

OLIGOSACCHARIDES;

BLOOD CLOTTING FACTOR 10A; C5 EPIMERASE; EPIMERASE; GLYCOSYLTRANSFERASE; HEPARAN SULFATE SULFOTRANSFERASE; HEPARIN; HEPARIN LYASE; N SULFOHENICOSASACCHARIDE; N SULFOHEPTADECASACCHARIDE; N SULFONANODECASACCHARIDE; N SULFOPENTADECASACCHARIDE; NITROUS ACID; OLIGOSACCHARIDE; PROTHROMBIN A; SULFOTRANSFERASE; SULFUR 35; THROMBOCYTE FACTOR 4; UNCLASSIFIED DRUG;

ANTI FACTOR IIA ACTIVITY; ANTI FACTOR XA ACTIVITY; ANTICOAGULATION; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CHEMOENZYMATIC SYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG PURITY; DRUG STRUCTURE; DRUG SULFATION; DRUG SYNTHESIS; EPIMERIZATION; INHIBITION KINETICS; PARTICLE SIZE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTICOAGULANTS; BACTERIAL PROTEINS; FACTOR XA; GLYCOSYLTRANSFERASES; HEPARIN; HUMANS; OLIGOSACCHARIDES; PASTEURELLA MULTOCIDA; PROTHROMBIN;

EID: 84865235998     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.358523     Document Type: Article

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