메뉴 건너뛰기




Volumn 67, Issue 3, 2012, Pages 195-204

The IDEAL study: Towards personalized drug treatment of hypertension

Author keywords

Drug treatment; Hypertension; Pharmacogenetics; Responders; Treatment response biomarkers

Indexed keywords

GLYCINE; INDAPAMIDE; PERINDOPRIL; PLACEBO; TRYPTOPHAN;

EID: 84865228735     PISSN: 00405957     EISSN: 19585578     Source Type: Journal    
DOI: 10.2515/therapie/2012031     Document Type: Article
Times cited : (3)

References (43)
  • 1
    • 0030056841 scopus 로고    scopus 로고
    • New meta-analysis of treatment trials of hypertension: Improving the estimate of therapeutic benefit
    • Gueyffier F, Froment A, Gouton M. New meta-analysis of treatment trials of hypertension: Improving the estimate of therapeutic benefit. J Hum Hypertens 1996; 10(1): 1-8
    • (1996) J Hum Hypertens , vol.10 , Issue.1 , pp. 1-8
    • Gueyffier, F.1    Froment, A.2    Gouton, M.3
  • 2
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009; 338: b1665
    • (2009) BMJ , vol.338
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 3
    • 0029156607 scopus 로고
    • Indana: A meta-analysis on individual patient data in hypertension protocol and preliminary results
    • Gueyffier F, Boutitie F, Boissel JP, et al. Indana: A meta-analysis on individual patient data in hypertension. Protocol and preliminary results. Therapie 1995; 50: 353-62
    • (1995) Therapie , vol.50 , pp. 353-362
    • Gueyffier, F.1    Boutitie, F.2    Boissel, J.P.3
  • 4
    • 0014952910 scopus 로고
    • Results in patients with diastolic blood pressure averaging 90 through 114 mm hg
    • Effects of treatment on morbidity in hypertension. II
    • Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm hg. JAMA 1970; 213: 1143-52
    • (1970) JAMA , vol.213 , pp. 1143-1152
  • 5
    • 0014200585 scopus 로고
    • Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm hg
    • Veterans administration cooperative study group on antihypertensive agents
    • Veterans administration cooperative study group on antihypertensive agents. Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm hg. JAMA 1967; 202: 1028-34
    • (1967) JAMA , vol.202 , pp. 1028-1034
  • 6
    • 0028811682 scopus 로고
    • A preliminary result. Pats collaborating group
    • Post-stroke antihypertensive treatment study
    • Post-stroke antihypertensive treatment study. A preliminary result. Pats collaborating group. Chin Med J (Engl) 1995; 108: 710-7
    • (1995) Chin Med J (Engl , vol.108 , pp. 710-717
  • 7
    • 0035968623 scopus 로고    scopus 로고
    • Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack
    • Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358: 1033-41
    • (2001) Lancet , vol.358 , pp. 1033-1041
  • 8
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients the heart outcomes prevention evaluation study investigators
    • Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000; 342: 145-53
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3
  • 9
    • 34548420712 scopus 로고    scopus 로고
    • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial
    • Patel A, MacMahon S, Chalmers J, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial. Lancet 2007; 370: 829-40
    • (2007) Lancet , vol.370 , pp. 829-840
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 10
    • 0034627183 scopus 로고    scopus 로고
    • Effects of ace inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: Results of prospectively designed overviews of randomised trials. Blood pressure lowering treatment trialists' collaboration
    • Neal B, MacMahon S, Chapman N. Effects of ace inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: Results of prospectively designed overviews of randomised trials. Blood pressure lowering treatment trialists' collaboration. Lancet 2000; 356: 1955-64
    • (2000) Lancet , vol.356 , pp. 1955-1964
    • Neal, B.1    MacMahon, S.2    Chapman, N.3
  • 11
    • 0032513878 scopus 로고    scopus 로고
    • Effects of intensive bloodpressure lowering and low-dose aspirin in patients with hypertension: Principal results of the hypertension optimal treatment (HOT) randomised trial
    • Hot study group
    • Hansson L, Zanchetti A, Carruthers SG, et al. Effects of intensive bloodpressure lowering and low-dose aspirin in patients with hypertension: Principal results of the hypertension optimal treatment (HOT) randomised trial. Hot study group. Lancet 1998; 351: 1755-62
    • (1998) Lancet , vol.351 , pp. 1755-1762
    • Hansson, L.1    Zanchetti, A.2    Carruthers, S.G.3
  • 12
    • 61949361523 scopus 로고    scopus 로고
    • Principal results of the japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS)
    • Principal results of the japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS). Hypertens Res 2008; 31: 2115-27
    • (2008) Hypertens Res , vol.31 , pp. 2115-2127
  • 13
    • 77954371687 scopus 로고    scopus 로고
    • Treatment of hypertension in patients 80 years and older: The lower the better? A metaanalysis of randomized controlled trials
    • Bejan-Angoulvant T, Saadatian-Elahi M, Wright JM, et al. Treatment of hypertension in patients 80 years and older: The lower the better? A metaanalysis of randomized controlled trials. J Hypertens 2010; 28: 1366-72
    • (2010) J Hypertens , vol.28 , pp. 1366-1372
    • Bejan-Angoulvant, T.1    Saadatian-Elahi, M.2    Wright, J.M.3
  • 14
    • 0025347391 scopus 로고
    • Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context
    • Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. Lancet 1990; 335: 827-38
    • (1990) Lancet , vol.335 , pp. 827-838
    • Collins, R.1    Peto, R.2    MacMahon, S.3
  • 15
    • 32944468102 scopus 로고    scopus 로고
    • Apparent effect on blood pressure is only partly responsible for the risk reduction due to antihypertensive treatments
    • Boissel JP, Gueyffier F, Boutitie F, et al. Apparent effect on blood pressure is only partly responsible for the risk reduction due to antihypertensive treatments. Fundam Clin Pharmacol 2005; 19: 579-84
    • (2005) Fundam Clin Pharmacol , vol.19 , pp. 579-584
    • Boissel, J.P.1    Gueyffier, F.2    Boutitie, F.3
  • 16
    • 0035922695 scopus 로고    scopus 로고
    • Cardiovascular protection and blood pressure reduction: A meta-analysis
    • Staessen JA, Wang JG, Thijs L. Cardiovascular protection and blood pressure reduction: A meta-analysis. Lancet 2001; 358: 1305-15
    • (2001) Lancet , vol.358 , pp. 1305-1315
    • Staessen, J.A.1    Wang, J.G.2    Thijs, L.3
  • 17
    • 0025234906 scopus 로고
    • Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias
    • MacMahon S, Peto R, Cutler J, et al. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765-74
    • (1990) Lancet , vol.335 , pp. 765-774
    • MacMahon, S.1    Peto, R.2    Cutler, J.3
  • 18
    • 0029828932 scopus 로고    scopus 로고
    • Presentation of octave II. A current epidemiologic study in france of the added prognostic value of ambulatory blood pressure monitoring
    • Gueyffier F, Boutitie F, Cornu C, et al. Presentation of octave II. A current epidemiologic study in france of the added prognostic value of ambulatory blood pressure monitoring. Arch Mal Coeur Vaiss 1996; 89: 1381-8
    • (1996) Arch Mal Coeur Vaiss , vol.89 , pp. 1381-1388
    • Gueyffier, F.1    Boutitie, F.2    Cornu, C.3
  • 19
    • 77955983000 scopus 로고    scopus 로고
    • Monitoring initial response to angiotensin-converting enzyme inhibitor-based regimens: An individual patient data meta-analysis from randomized, placebo-controlled trials
    • Bell KJ, Hayen A, Macaskill P, et al. Monitoring initial response to angiotensin-converting enzyme inhibitor-based regimens: An individual patient data meta-analysis from randomized, placebo-controlled trials. Hypertension 2010; 56: 533-9
    • (2010) Hypertension , vol.56 , pp. 533-539
    • Bell, K.J.1    Hayen, A.2    Macaskill, P.3
  • 20
    • 38349160645 scopus 로고    scopus 로고
    • Blood pressure variability causes spurious identification of hypertension in clinical studies: A computer simulation study
    • Turner MJ, van Schalkwyk JM. Blood pressure variability causes spurious identification of hypertension in clinical studies: A computer simulation study. Am J Hypertens 2008; 21: 85-91
    • (2008) Am J Hypertens , vol.21 , pp. 85-91
    • Turner, M.J.1    Van Schalkwyk, J.M.2
  • 21
    • 0027461577 scopus 로고
    • Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The department of veterans affairs cooperative study group on antihypertensive agents
    • Materson BJ, Reda DJ, Cushman WC, et al. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The department of veterans affairs cooperative study group on antihypertensive agents. N Engl J Med 1993; 328: 914-21
    • (1993) N Engl J Med , vol.328 , pp. 914-921
    • Materson, B.J.1    Reda, D.J.2    Cushman, W.C.3
  • 22
    • 0033549296 scopus 로고    scopus 로고
    • Optimisation of antihypertensive treatment by crossover rotation of four major classes
    • Dickerson JE, Hingorani AD, Ashby MJ, et al. Optimisation of antihypertensive treatment by crossover rotation of four major classes. Lancet 1999; 353: 2008-13
    • (1999) Lancet , vol.353 , pp. 2008-2013
    • Dickerson, J.E.1    Hingorani, A.D.2    Ashby, M.J.3
  • 23
    • 0028129008 scopus 로고
    • Within-patient correlation between the antihypertensive effects of atenolol, lisinopril and nifedipine
    • Attwood S, Bird R, Burch K, et al. Within-patient correlation between the antihypertensive effects of atenolol, lisinopril and nifedipine. J Hypertens 1994; 12: 1053-60
    • (1994) J Hypertens , vol.12 , pp. 1053-1060
    • Attwood, S.1    Bird, R.2    Burch, K.3
  • 24
    • 60649094697 scopus 로고    scopus 로고
    • Pharmacogenomics of antihypertensive drugs: Rationale and design of the pharmacogenomic evaluation of antihypertensive responses (PEAR) study
    • Johnson JA, Boerwinkle E, Zineh I, et al. Pharmacogenomics of antihypertensive drugs: Rationale and design of the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. Am Heart J 2009; 157: 442-9
    • (2009) Am Heart J , vol.157 , pp. 442-449
    • Johnson, J.A.1    Boerwinkle, E.2    Zineh, I.3
  • 25
    • 77955984609 scopus 로고    scopus 로고
    • Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension
    • Turner ST, Schwartz GL, Chapman AB, et al. Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension. Am J Hypertens 2010; 23: 1014-22
    • (2010) Am J Hypertens , vol.23 , pp. 1014-1022
    • Turner, S.T.1    Schwartz, G.L.2    Chapman, A.B.3
  • 26
    • 0035097086 scopus 로고    scopus 로고
    • Ace inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension
    • Morgan TO, Anderson AI, MacInnis RJ. Ace inhibitors, beta-blockers, calcium blockers, and diuretics for the control of systolic hypertension. Am J Hypertens 2001; 14: 241-7
    • (2001) Am J Hypertens , vol.14 , pp. 241-247
    • Morgan, T.O.1    Anderson, A.I.2    MacInnis, R.J.3
  • 27
    • 0030898258 scopus 로고    scopus 로고
    • Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension
    • Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997; 349: 1353-7
    • (1997) Lancet , vol.349 , pp. 1353-1357
    • Cusi, D.1    Barlassina, C.2    Azzani, T.3
  • 28
    • 0034816118 scopus 로고    scopus 로고
    • On behalf of the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) Trial. Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients
    • Kurland L, Melhus H, Karlsson J, et al. On behalf of the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) Trial. Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients. J Hypertens 2001; 19: 1783-7
    • (2001) J Hypertens , vol.19 , pp. 1783-1787
    • Kurland, L.1    Melhus, H.2    Karlsson, J.3
  • 29
    • 0037385575 scopus 로고    scopus 로고
    • A common beta1-adrenergic receptor polymorphism (arg389gly) affects blood pressure response to betablockade
    • Sofowora GG, Dishy V, Muszkat M, et al. A common beta1-adrenergic receptor polymorphism (arg389gly) affects blood pressure response to betablockade. Clin Pharmacol Ther 2003; 73: 366-71
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 366-371
    • Sofowora, G.G.1    Dishy, V.2    Muszkat, M.3
  • 30
    • 70450221929 scopus 로고    scopus 로고
    • Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population
    • van Rijn-Bikker PC, Mairuhu G, van Montfrans GA, et al. Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population. Am J Hypertens 2009; 22: 1295-302
    • (2009) Am J Hypertens , vol.22 , pp. 1295-1302
    • Van Rijn-Bikker, P.C.1    Mairuhu, G.2    Van Montfrans, G.A.3
  • 31
    • 33847183510 scopus 로고    scopus 로고
    • Predictors of antihypertensive drug responses: Initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (the GENRES study
    • Hiltunen TP, Suonsyrja T, Hannila-Handelberg T, et al. Predictors of antihypertensive drug responses: Initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (the GENRES study). Am J Hypertens 2007; 20: 311-8
    • (2007) Am J Hypertens , vol.20 , pp. 311-318
    • Hiltunen, T.P.1    Suonsyrja, T.2    Hannila-Handelberg, T.3
  • 32
    • 43449139148 scopus 로고    scopus 로고
    • Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: Results from the randomized, double-blind, crossover GENRES study
    • Suonsyrja T, Hannila-Handelberg T, Paavonen KJ, et al. Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: Results from the randomized, double-blind, crossover GENRES study. J Hypertens 2008; 26: 1250-6
    • (2008) J Hypertens , vol.26 , pp. 1250-1256
    • Suonsyrja, T.1    Hannila-Handelberg, T.2    Paavonen, K.J.3
  • 33
    • 77951498126 scopus 로고    scopus 로고
    • Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment
    • Suonsyrja T, Donner K, Hannila-Handelberg T, et al. Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment. Pharmacogenet Genomics 2010; 20: 342-5
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 342-345
    • Suonsyrja, T.1    Donner, K.2    Hannila-Handelberg, T.3
  • 34
    • 21644466324 scopus 로고    scopus 로고
    • Pharmacogenomics of blood pressure response to antihypertensive treatment
    • Mellen PB, Herrington DM. Pharmacogenomics of blood pressure response to antihypertensive treatment. J Hypertens 2005; 23: 1311-25
    • (2005) J Hypertens , vol.23 , pp. 1311-1325
    • Mellen, P.B.1    Herrington, D.M.2
  • 35
    • 67651165181 scopus 로고    scopus 로고
    • Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension̊
    • Arnett DK, Claas SA, Lynch AI. Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension̊ Curr Opin Cardiol 2009; 24: 333-9
    • (2009) Curr Opin Cardiol , vol.24 , pp. 333-339
    • Arnett, D.K.1    Claas, S.A.2    Lynch, A.I.3
  • 36
    • 77950347809 scopus 로고    scopus 로고
    • Pharmacogenomics of antihypertensive drugs: Past, present and future
    • Johnson JA. Pharmacogenomics of antihypertensive drugs: Past, present and future. Pharmacogenomics 2010; 11: 487-91
    • (2010) Pharmacogenomics , vol.11 , pp. 487-491
    • Johnson, J.A.1
  • 37
    • 77951498126 scopus 로고    scopus 로고
    • Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment
    • Suonsyrja T, Donner K, Hannila-Handelberg T, et al. Common genetic variation of beta1- and beta2-adrenergic receptor and response to four classes of antihypertensive treatment. Pharmacogenet Genomics 2010; 20: 342-5
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 342-345
    • Suonsyrja, T.1    Donner, K.2    Hannila-Handelberg, T.3
  • 38
    • 33646502204 scopus 로고    scopus 로고
    • QxDB: A generic database to support mathematical modelling in biology. Philos Transact A Math Phys
    • Ribba B, Tracqui P, Boix JL, et al. QxDB: A generic database to support mathematical modelling in biology. Philos Transact A Math Phys Eng Sci 2006; 364: 1517-32
    • (2006) Eng Sci , vol.364 , pp. 1517-1532
    • Ribba, B.1    Tracqui, P.2    Boix, J.L.3
  • 39
    • 48349110500 scopus 로고    scopus 로고
    • Saphir: A physiome core model of body fluid homeostasis and blood pressure regulation. Philos Transact A Math Phys
    • Thomas SR, Baconnier P, Fontecave J, et al. Saphir: A physiome core model of body fluid homeostasis and blood pressure regulation. Philos Transact A Math Phys Eng Sci 2008; 366: 3175-97
    • (2008) Eng Sci , vol.366 , pp. 3175-3197
    • Thomas, S.R.1    Baconnier, P.2    Fontecave, J.3
  • 40
    • 48349090631 scopus 로고    scopus 로고
    • The EuroPhysiome, STEP and a roadmap for the virtual physiological human. Philos Transact A Math Phys
    • Fenner JW, Brook B, Clapworthy G, et al. The EuroPhysiome, STEP and a roadmap for the virtual physiological human. Philos Transact A Math Phys Eng Sci 2008; 366: 2979-99
    • (2008) Eng Sci , vol.366 , pp. 2979-2999
    • Fenner, J.W.1    Brook, B.2    Clapworthy, G.3
  • 41
    • 77953529580 scopus 로고    scopus 로고
    • A vision and strategy for the virtual physiological human in 2010 and beyond
    • Hunter P, Coveney PV, de Bono B, et al. A vision and strategy for the virtual physiological human in 2010 and beyond. Philos Transact A Math Phys Eng Sci 2010; 368: 2595-614
    • (2010) Philos Transact A Math Phys Eng Sci , Issue.368 , pp. 2595-2614
    • Hunter, P.1    Coveney, P.V.2    De Bono, B.3
  • 42
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensinconverting enzyme inhibitor or calcium channel blocker vs diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
    • Major outcomes in high-risk hypertensive patients randomized to angiotensinconverting enzyme inhibitor or calcium channel blocker vs diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002; 288: 2981-97
    • (2002) JAMA , vol.288 , pp. 2981-2997


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.