Protective effects of glutamine in a rat model of endotoxemia

Molecular Medicine Reports

Volumn 6, Issue 4, 2012, Pages 739-744

  Zhao, Ya Juan ^a   Wang, Hong ^a   Liu, Xin ^a   Sun, Mei ^a   Kazuhiro, Haginoya ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Takuto Rehabilitation Center for Children   (Japan)

Author keywords

Apoptosis; Brain; Endotoxemia; Glutamine; Heat shock protein; Lipopolysaccharide; Nuclear factor B; Platelet derived growth factor

Indexed keywords

GLUTAMINE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN CORTEX; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; ENDOTOXEMIA; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BRAIN; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; FEMALE; GLUTAMINE; HSP70 HEAT-SHOCK PROTEINS; LIPOPOLYSACCHARIDES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, WISTAR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; UP-REGULATION;

EID: 84865199803     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1007     Document Type: Article

References (26)

1. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM and Chang EB: Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol 90: 2403-2410, 2001. (Pubitemid 32467436)
2. Opie LH: Reperfusion injury and its pharmacologic modification. Circulation 80: 1049-1062, 1989.
3. Ribeiro SP, Villar J and Slutsky AS: Induction of the stress response to prevent organ injury. New Horiz 3: 301-311, 1995.
4. De Maio A: Heat shock proteins: facts, thoughts, and dreams. Shock 11: 1-12, 1999.
5. Chu EK, Ribeiro SP and Slutsky AS: Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med 25: 1727-1732, 1997. (Pubitemid 27435511)
6. Stice JP and Knowlton AA: Estrogen, NFkappaB, and the heat shock response. Mol Med 14: 517-527, 2008.
7. Voegeli TS, Wintink AJ, Chen Y and Currie RW: Heat shock proteins 27 and 70 regulating angiotensin II-induced NF-kappaB: a possible connection to blood pressure control? Appl Physiol Nutr Metab 33: 1042-1049, 2008.
8. Yoo CG, Lee S, Lee CT, Kim YW, Han SK and Shim YS: Antiinflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells. J Immunol 164: 5416-5423, 2000. (Pubitemid 30305224)
9. Rogister B, Ben-Hur T and Dubois-Dalcq M: From neural stem cells to myelinating oligodendrocytes. Mol Cell Neurosci 14: 287-300, 1999. (Pubitemid 29506160)
10. Dubois-Dalcq M and Murray K: Why are growth factors important in oligodendrocyte physiology? Pathol Biol (Paris) 48: 80-86, 2000. (Pubitemid 30136680)
11. Morioka I, Tsuneishi S, Takada S and Matsuo M: PDGF-alpha receptor expression following hypoxic-ischemic injury in the neonatal rat brain. Kobe J Med Sci 50: 21-30, 2004. (Pubitemid 40136932)
12. Liu JC, Wang HT and Wang W: Protective effects of alanylglutamine on acute lung injury induced by lipopolysaccharide in rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban 33: 1095-1100, 2008.
13. Jacob A, Hensley LK, Safratowich BD, Quigg RJ and Alexander JJ: The role of the complement cascade in endotoxininduced septic encephalopathy. Lab Invest 87: 1186-1194, 2007. (Pubitemid 350126709)
14. Caruso C, Durand D, Schiöth HB, Rey R, Seilicovich A and Lasaga M: Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology 148: 4918-4926, 2007. (Pubitemid 47481532)
15. Islam Z, Amuzie CJ, Harkema JR and Pestka JJ: Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure. Toxicol Sci 98: 526-541, 2007. (Pubitemid 47244821)
16. Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L and Heneka MT: Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat 30: 144-157, 2005. (Pubitemid 41338695)
17. Chen G, Shi J, Hu Z and Hang C: Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm 2008: 716458, 2008.
18. Chen NJ, Chio II, Lin WJ, et al: Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci USA 105: 12429-12434, 2008.
19. Wang XM, Liang MF, Yuan Y and Jiang W: The different effects of glutamine on macrophage cytokines release in vivo and in vitro. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20: 456-460, 2008 (In Chinese).
20. Potula R, Dhillion N, Sui Y, Zien CA, Funa K, Pinson D, Mayo MS, Singh DK, Narayan O and Buch S: Association of platelet-derived growth factor-B chain with simian human immunodeficiency virus encephalitis. Am J Pathol 165: 815-824, 2004. (Pubitemid 39129289)
21. Xiyang YB, Liu S, Liu J, Hao CG, Wang ZJ, NI W, Wang XY and Wang TH: Roles of platelet-derived growth factor-B expression in the ventral horn and motor cortex in the spinal cord-hemisected rhesus monkey. J Neurotrauma 26: 275-287, 2009.
22. Tseng HC and Dichter MA: Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. Neurobiol Dis 19: 77-83, 2005. (Pubitemid 40544725)
23. Iantomasi T, Favilli F, Catarzi S and Vincenzini MT: GSH role on platelet-derived growth factor receptor tyrosine phosphorylation induced by H2O2. Biochem Biophys Res Commun 280: 1279-1285, 2001. (Pubitemid 32917782)
24. Peng F, Dhillon N, Callen S, Yao H, Bokhari S, Zhu X, Baydoun HH and Buch S: Platelet-derived growth factor protects neurons against gp120-mediated toxicity. J Neurovirol 14: 62-72, 2008. (Pubitemid 351314974)
25. Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M and Funa K: Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice. Mol Cell Neurosci 37: 507-518, 2008.
26. Beazely MA, Weerapura M and Macdonald JF: Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons. Mol Brain 1: 20, 2008.