Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent

Drug Metabolism and Disposition

Volumn 40, Issue 9, 2012, Pages 1810-1816

  Scicinski, Jan ^a   Oronsky, Bryan ^a   Taylor, Michael ^c   Luo, Gang ^b   Musick, Timothy ^b   Marini, Joseph ^b   Adams, Christopher M ^d   Fitch, William L ^d  

^a RadioRx Inc   (United States)

^b 206 Carnegie Center   (United States)

^c NonClinical Safety Assessment   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBON 14; DRUG METABOLITE; PEPTIDE; RRX 001; RRX 001 CYSTEINE; RRX 001 GLUTATHIONE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BLOOD; DOG; DRUG DISPOSITION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; ERYTHROCYTE; EVALUATION; HAPLORHINI; HUMAN; HUMAN TISSUE; IN VITRO STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PLASMA; PRIORITY JOURNAL; PROTEIN STRUCTURE; RADIATION DETECTION; RADIOACTIVITY; RAT; SINGLE DRUG DOSE; URINARY EXCRETION;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; AZETIDINES; BETA-GLOBINS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CYSTEINE; DOGS; ERYTHROCYTES; HAPLORHINI; HEMOGLOBINS; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; METABOLIC CLEARANCE RATE; NITRO COMPOUNDS; PEPTIDE MAPPING; PROTEIN BINDING; PROTEOMICS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84865197750     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046755     Document Type: Article

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