Scintigraphic evaluation of intra-arterial and intravenous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using 99mTc-HMPAO

Equine Veterinary Journal

Volumn 44, Issue 5, 2012, Pages 594-599

  Sole, A ^a   Spriet, M ^b   Galuppo, L D ^b   Padgett, K A ^b   Borjesson, D L ^b   Wisner, E R ^b   Brosnan, R J ^b   Vidal, M A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hexamethyl propylene amine oxime; HMPAO; Horse; Mesenchymal stem cells; Regional limb perfusion; Scintigraphy; Technetium

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT;

ALLOTRANSPLANTATION; ANIMAL; ANIMAL DISEASE; ARTICLE; BONE MARROW CELL; FEMALE; FORELIMB; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; PHYSIOLOGY; SCINTISCANNING; VASCULARIZATION;

ANIMALS; BONE MARROW CELLS; FEMALE; FORELIMB; INFUSIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M EXAMETAZIME; TRANSPLANTATION, HOMOLOGOUS;

EQUIDAE;

EID: 84865195356     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2011.00530.x     Document Type: Article

References (34)

1. Frisbie, D.D. and Smith, R.K. (2010) Clinical update on the use of mesenchymal stem cells in equine orthopaedics. Equine Vet. J. 42, 86-89.
2. Nixon, A.J., Dahlgren, L.A., Haupt, J.L., Yeager, A.E. and Ward, D.L. (2008) Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. Am. J. Vet. Res. 69, 928-937.
3. Schnabel, L.V., Lynch, M.E., van der Meulen, M.C., Yeager, A.E., Kornatowski, M.A. and Nixon, A.J. (2009) Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons. J. Orthop. Res. 27, 1392-1398.
4. Watts, A.E., Yeager, A.E., Kopyov, O.V. and Nixon, A.J. (2011) Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model. Stem Cell Res. Ther. 2, 4.
5. Smith, R.K. (2008) Mesenchymal stem cell therapy for equine tendinopathy. Disabil. Rehabil. 30, 1752-1758.
6. Godwin, E.E., Young, N.J., Dudhia, J., Beamish, I.C. and Smith, R.K. (2012) Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon. Equine Vet. J. 44, 25-32.
7. Guest, D.J., Smith, M.R. and Allen, W.R. (2010) Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon. Equine Vet. J. 42, 636-642.
8. Sutter, W.W. (2007) Autologous cell-based therapy for tendon and ligament injuries. Clin. Tech. Equine Pract. 6, 198-208.
9. Vaughan, B., Whitcomb, M.B. and Maher, O. (2009) How to improve accuracy of ultrasound-guided procedures. Proc. Am. Ass. Equine Practnrs. 55, 438-448.
10. Anderson, J.D.C., Puchalski, S.M., Larson, R.F., Delco, M.L. and Snyder, J.R. (2008) Injection of the insertion of the deep digital flexor tendon in horses using radiographic guidance. Equine Vet. Educ. 20, 383-388.
11. Barbash, I.M., Chouraqui, P., Baron, J., Feinberg, M.S., Etzion, S., Tessone, A., Miller, L., Guetta, E., Zipori, D., Kedes, L.H., Kloner, R.A. and Leor, J. (2003) Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108, 863-868.
12. Capoccia, B.J., Robson, D.L., Levac, K.D., Maxwell, D.J., Hohm, S.A., Neelamkavil, M.J., Bell, G.I., Xenocostas, A., Link, D.C., Piwnica-Worms, D., Nolta, J.A. and Hess, D.A. (2009) Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood 113, 5340-5351.
13. Mattson, S.E., Pearce, S.G., Boure, L.P., Dobson, H., Hurtig, M.B. and Black, W.D. (2005) Comparison of intraosseous and intravenous infusion of technetium Tc 99m pertechnate in the distal portion of forelimbs in standing horses by use of scintigraphic imaging. Am. J. Vet. Res. 66, 1267-1272.
14. Rubio-Martinez, L.M. and Cruz, A.M. (2006) Antimicrobial regional limb perfusion in horses. J. Am. Vet. Med. Ass. 228, 706-712.
15. Whitehair, K.J., Blevins, W.E., Fessler, J.F., Van Sickle, D.C., White, M.R. and Bill, R.P. (1992) Regional perfusion of the equine carpus for antibiotic delivery. Vet. Surg. 21, 279-285.
16. Welling, M.M., Duijvestein, M., Signore, A. and van der Weerd, L. (2011) In vivo biodistribution of stem cells using molecular nuclear medicine imaging. J. Cell. Physiol. 226, 1444-1452.
17. Mortelmans, L., Malbrain, S., Stuyck, J., De Backker, C., Heynen, M.J., Boogaerts, M., De Roo, M. and Verbruggen, A. (1989) In vitro and in vivo evaluation of granulocyte labeling with [99mTc]d, 1-HM-PAO. J. Nucl. Med. 30, 2022-2028.
18. Long, C.D., Galuppo, L.D., Waters, N.K. and Hornof, W.J. (2000) Scintigraphic detection of equine orthopedic infection using Tc-HMPAO labeled leukocytes in 14 horses. Vet. Radiol. Ultrasound 41, 354-359.
19. Daniel, G.B., Tucker, R.L., Buckman, T. and Daniel, S.L. (1992) In vitro comparison of equine granulocytes labeled with 99mTc-hexamethylpropyleneamine oxime or 111In-oxine. Am. J. Vet. Res. 53, 871-876.
20. Detante, O., Moisan, A., Dimastromatteo, J., Richard, M.J., Riou, L., Grillon, E., Barbier, E., Desruet, M.D., De Fraipont, F., Segebarth, C., Jaillard, A., Hommel, M., Ghezzi, C. and Remy, C. (2009) Intravenous administration of 99mTc-HMPAO-labeled human mesenchymal stem cells after stroke: in vivo imaging and biodistribution. Cell Transplant. 18, 1369-1379.
21. Assis, A.C., Carvalho, J.L., Jacoby, B.A., Ferreira, R.L., Castanheira, P., Diniz, S.O., Cardoso, V.N., Goes, A.M. and Ferreira, A.J. (2010) Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart. Cell Transplant. 19, 219-230.
22. Yoon, C.H., Hur, J., Oh, I.Y., Park, K.W., Kim, T.Y., Shin, J.H., Kim, J.H., Lee, C.S., Chung, J.K., Park, Y.B. and Kim, H.S. (2006) Intercellular adhesion molecule-1 is upregulated in ischemic muscle, which mediates trafficking of endothelial progenitor cells. Arterioscler. Thromb. Vasc. Biol. 26, 1066-1072.
23. Khan, A.A., Shaik, M.V., Parveen, N., Rajendraprasad, A., Aleem, M.A., Habeeb, M.A., Srinivas, G., Raj, T.A., Tiwari, S.K., Kumaresan, K., Venkateswarlu, J., Pande, G. and Habibullah, C. (2010) Human fetal liver-derived stem cell transplantation as supportive modality in the management of end-stage decompensated liver cirrhosis. Cell Transplant. 19, 409-418.
24. Barbosa da Fonseca, L.M., Gutfilen, B., Rosado de Castro, P.H., Battistella, V., Goldenberg, R.C., Kasai-Brunswick, T., Chagas, C.L., Wajnberg, E., Maiolino, A., Salles Xavier, S., Andre, C., Mendez-Otero, R. and de Freitas, G.R. (2010) Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Expt. Neurol. 221, 122-128.
25. Guest, D.J., Smith, M.R. and Allen, W.R. (2008) Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Vet. J. 40, 178-181.
26. Carrade, D.D., Owens, S.D., Galuppo, L.D., Vidal, M.A., Ferraro, G.L., Librach, F., Buerchler, S., Friedman, M.S., Walker, N.J. and Borjesson, D.L. (2011) Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally derived equine mesenchymal stem cells in horses. Cytotherapy 13, 419-430.
27. Vidal, M.A., Kilroy, G.E., Johnson, J.R., Lopez, M.J., Moore, R.M. and Gimble, J.M. (2006) Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacity. Vet. Surg. 35, 601-610.
28. Toupadakis, C.A., Wong, A., Genetos, D.C., Cheung, W.K., Borjesson, D.L., Ferraro, G.L., Galuppo, L.D., Leach, J.K., Owens, S.D. and Yellowley, C.E. (2010) Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue. Am. J. Vet. Res. 71, 1237-1245.
29. Sampson, C.B., Solanki, C. and Barber, R.W. (1991) 99Tcm-exametazime-labelled leucocytes: effect of volume and concentration of exametazime on labelling efficiency, and clinical protocol for high efficiency multi-dose radiolabelling. Nucl. Med. Commun. 12, 719-723.
30. Daniel, G.B. and Berry, C.R. (2006) Textbook of Veterinary Nuclear Medicine, 2nd edn., American College of Veterinary Radiology, Knoxville, TN, 421 p.
31. Kester, W.O. (1991) Definition and classification of lameness. In: Guide for Veterinary Services and Judging of Equestrian Events, 4th edn., Ed: Colorado: AAEP, American Association of Equine Practitioners, Lexington. p 19.
32. Chin, B.B., Nakamoto, Y., Bulte, J.W., Pittenger, M.F., Wahl, R. and Kraitchman, D.L. (2003) 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl. Med. Commun. 24, 1149-1154.
33. Aicher, A., Brenner, W., Zuhayra, M., Badorff, C., Massoudi, S., Assmus, B., Eckey, T., Henze, E., Zeiher, A.M. and Dimmeler, S. (2003) Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 107, 2134-2139.
34. Dyce, K.M., Sack, W.O. and Wensing, C.J.G. (2010) Textbook of Veterinary Anatomy, 4th edn., Saunders/Elsevier, St. Louis. p xii. 834 p.