ShRNA-mediated gene silencing of AHR promotes the differentiation of P19 mouse embryonic carcinoma cells into cardiomyocytes

Molecular Medicine Reports

Volumn 6, Issue 3, 2012, Pages 513-518

  Zhu, Chun ^a   Chen, Yu Lin ^a   Wang, Xue Jie ^a   Hu, Xiao Shan ^a   Yu, Zhang Bin ^a   Han, Shu Ping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AHR and Wnt signal transduction pathway; Aryl hydrocarbon receptor; Heart development; Short hairpin RNA

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BETA CATENIN; CYTOCHROME P450 1A1; DIMETHYL SULFOXIDE; HYPOXIA INDUCIBLE FACTOR 1BETA; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5;

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE SILENCING; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WNT SIGNALING PATHWAY;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BETA CATENIN; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DIMETHYL SULFOXIDE; EMBRYONAL CARCINOMA STEM CELLS; GATA4 TRANSCRIPTION FACTOR; GLYCOGEN SYNTHASE KINASE 3; HOMEODOMAIN PROTEINS; MICE; MYOCYTES, CARDIAC; RECEPTORS, ARYL HYDROCARBON; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; WNT SIGNALING PATHWAY;

EID: 84865189217     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.941     Document Type: Article

References (22)

1. Olson EN: Gene regulatory networks in the evolution and develop ment of the heart. Science 313: 1922-1927, 2006.
2. Hsiao SM, Wu MH, Jou HJ, Lee CN, Shyu MK, Shih JC and Hsieh FJ: Outcome for fetuses with prenatally detected congenital heart disease and cardiac arrhythmias in Taiwan. J Formos Med Assoc 106: 423-431, 2007.
3. Hennig B, Meerarani P, Slim R, Toborek M, Daugherty A, Silverstone AE and Robertson LW: Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181: 174-183, 2002. (Pubitemid 34757087)
4. Pelclová D, Urban P, Preiss J, Lukás E, Fenclová Z, Navrátil T, Dubská Z and Senholdová Z: Adverse health effects in humans exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Rev Environ Health 21: 119-138, 2006.
5. DeWitt JC, Millsap DS, Yeager RL, Heise SS, Sparks DW and Henshel DS: External heart deformities in passerine birds exposed to environmental mixtures of polychlorinated biphenyls during development. Environ Toxicol Chem 25: 541-551, 2006. (Pubitemid 43134258)
6. Majkova Z, Smart E, Toborek M and Hennig B: Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol Appl Pharmacol 237: 1-7, 2009.
7. Hong Y, Chunhong Z and Xiaoxiong Z: Investigation of pollution characteristics of polychlorinated biphenyls in the typical drinking water sources in Jiangsu Province, China. Environ Monit Assess 158: 573-579, 2009.
8. Shen H, Shen H, Han J, Tie X, Xu W, Ren Y and Ye C: Polychlorinated dibenzo-p-dioxins/furans and polychlorinated biphenyls in human adipose tissue from Zhejiang Province, China. Chemosphere 74: 384-388, 2009.
9. Suzuki G, Nakano M and Nakano S: Distribution of PCDDs/PCDFs and co-PCBs in human maternal blood, cord blood, placenta, milk, and adipose tissue: dioxins showing high toxic equivalency factor accumulate in the placenta. Biosci Biotechnol Biochem 69: 1836-1847, 2005. (Pubitemid 41558846)
10. Shen H, Shen H, Main KM, Virtanen HE, Damggard IN, Haavisto AM, Kaleva M, Boisen KA, Schmidt IM, Chellakooty M, Skakkebaek NE, Toppari J and Schramm KW: From mother to child: investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere 67: S256-S262, 2007. (Pubitemid 46367162)
11. Liu S and Piatigorsky J: Regulation of mouse small heat shock protein αb-crystallin gene by aryl hydrocarbon receptor. PLoS One 6: e17904, 2011.
12. Shimada T, Sugie A, Shindo M, Nakajima T, Azuma E, Hashimoto M and Inoue K: Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Toxicol Appl Pharmacol 187: 1-10, 2003. (Pubitemid 36293561)
13. Manoharan M: RNA interference and chemically modified small interfering RNAs. Curr Opin Chem Biol 8: 570-579, 2004.
14. Han SG, Eum SY, Toborek M, Smart E and Hennig B: Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice. Toxicol Appl Pharmacol 246: 74-82, 2010.
15. Hennig B, Reiterer G, Majkova Z, Oesterling E, Meerarani P and Toborek M: Modification of environmental toxicity by nutrients: implications in atherosclerosis. Cardiovasc Toxicol 5: 153-160, 2005. (Pubitemid 41058629)
16. Grimes AC, Erwin KN, Stadt HA, Hunter GL, Gefroh HA, Tsai HJ and Kirby ML: PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development. Toxicol Sci 106: 193-205, 2008.
17. Lund AK, Peterson SL, Timmins GS and Walker MK: Endothelin-1-mediated increase in reactive oxygen species and NADPH oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice. Toxicol Sci 88: 265-273, 2005. (Pubitemid 41548768)
18. Shevtsov SP, Haq S and Force T: Activation of beta-catenin signaling pathways by classical G-protein-coupled receptors: mechanisms and consequences in cycling and non-cycling cells. Cell Cycle 5: 2295-2300, 2006. (Pubitemid 44785835)
19. Nakamura T, Sano M, Songyang Z and Schneider MD: A Wnt-and beta-catenin-dependent pathway for mammalian cardiac myogenesis. Proc Natl Acad Sci USA 100: 5834-5839, 2003. (Pubitemid 36576894)
20. Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR and Srivastava D: Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci USA 104: 10894-10899, 2007. (Pubitemid 47175197)
21. Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH and Martin JF: Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci USA 104: 9319-9324, 2007. (Pubitemid 47185777)
22. Mathew LK, Sengupta SS, Ladu J, Andreasen EA and Tanguay RL: Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J 22: 3087-3096, 2008.