Lambert-eaton myasthenic syndrome; Pathogenesis, diagnosis, and therapy

Autoimmune Diseases

Volumn 1, Issue 1, 2011, Pages

  Gilhus, Nils Erik ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIAMINOPYRIDINE; 3,4 DIAMINOPYRIDINE PHOSPHATE; AUTOANTIBODY; AZATHIOPRINE; CHOLINESTERASE INHIBITOR; CYCLOSPORIN; HLA B8 ANTIGEN; IMMUNOGLOBULIN; MYCOPHENOLIC ACID; PREDNISOLONE; PREDNISONE; PYRIDOSTIGMINE; RITUXIMAB; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL ANTIBODY;

AUTONOMIC DYSFUNCTION; CELL MEMBRANE; CLINICAL FEATURE; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; EATON LAMBERT SYNDROME; EPIDEMIOLOGICAL DATA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LUNG SMALL CELL CANCER; MOTOR NERVE; MUSCLE WEAKNESS; MYASTHENIA GRAVIS; NERVE FIBER; PARANEOPLASTIC SYNDROME; PRESYNAPTIC NERVE; PRIORITY JOURNAL; REVIEW; SERODIAGNOSIS; T LYMPHOCYTE; TRAINING;

EID: 84865166763     PISSN: None     EISSN: 20900430     Source Type: Journal    
DOI: 10.4061/2011/973808     Document Type: Review

References (33)

1. Lambert E. H., Eaton L. M., Rooke E. D., Defect of neuromuscular conduction associated with malignant neoplasms American Journal of Physiology 1956 187 612 613
2. Wirtz P. W., Nijnuis M. G., Sotodeh M., Willems L. N. A., Brahim J. J., Putter H., Wintzen A. R., Verschuuren J. J., The epidemiology of myasthenia gravis, Lambert-Eaton myasthenic syndrome and their associated tumours in the northern part of the province of South Holland Journal of Neurology 2003 250 6 698 701 (Pubitemid 36718358)
3. Titulaer M. J., Verschuuren J. J. G. M., Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms Annals of the New York Academy of Sciences 2008 1132 129 134 (Pubitemid 351841370)
4. Lorenzoni P. J., Scola R. H., Kay C. S. K., Parolin S. F., Werneck L. C., Non-paraneoplastic Lambert-Eaton myasthenic syndrome Arq Neuropsiquiatr 2010 68 6 849 854
5. Elrington G. M., Murray N. M. F., Spiro S. G., Newsom-Davis J., Neurological paraneoplastic syndromes in patients with small cell lung cancer Journal of Neurology Neurosurgery and Psychiatry 1991 54 9 764 767
6. Titulaer M. J., Klooster R., Potman M., Sabater L., Graus F., Hegeman I. M., Thijssen P. E., Wirtz P. W., Twijnstra A., Smitt P. A. E., Van Der Maarel S., Verschuuren J. J. G. M., SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival Journal of Clinical Oncology 2009 27 26 4260 4267
7. Titulaer M. J., Wirtz P. W., Kuks J. B. M., Schelhaas H. J., van der Kooi A. J., Faber C. G., van der Pol W. L., de Visser M., Sillevis Smitt P. A. E., Verschuuren J. J. G. M., The Lambert-Eaton myasthenic syndrome 19882008: a clinical picture in 97 patients Journal of Neuroimmunology 2008 201-202 153 158
8. Pellkofer H. L., Armbruster L., Linke R., Schumm F., Voltz R., Managing non-paraneoplastic Lambert-Eaton myasthenic syndrome: clinical characteristics in 25 German patients Journal of Neuroimmunology 2009 217 1-2 90 94
9. Quartel A., Turbeville S., Lounsbury D., Current therapy for Lambert-Eaton myasthenic syndrome: development of 3,4-diaminopyridine phosphate salt as first-line symptomatic treatment Current Medical Research and Opinion 2010 26 6 1363 1375
10. Waterman S. A., Lang B., Newsom-Davis J., Effect of Lambert-Eaton myasthenic syndrome antibodies on autonomic neurons in the mouse Annals of Neurology 1997 42 2 147 156 (Pubitemid 27340458)
11. Takamori M., Lambert-Eaton myasthenic syndrome: search for alternative autoimmune targets and possible compensatory mechanisms based on presynaptic calcium homeostasis Journal of Neuroimmunology 2008 201-202 145 152
12. Urbano F. J., Pagani M. R., Uchitel O., Calcium channels, neuromuscular synaptic transmission and neurological diseases Journal of Neuroimmunology 2008 201-202 136 144
13. Motomura M., Johnston I., Lang B., Vincent A., Newsom-Davis J., An improved diagnostic assay for Lambert-Eaton myasthenic syndrome Journal of Neurology Neurosurgery and Psychiatry 1995 58 1 85 87
14. Verschuuren J. J., Dalmau J., Tunkel R., Lang B., Graus F., Schramm L., Posner J. B., Newsom-Davis J., Rosenfeld M. R., Antibodies against the calcium channel beta-subunit in Lambert-Eaton myasthenic syndrome Neurology 1998 50 2 475 479 (Pubitemid 28119792)
15. Pellkofer H. L., Armbruster L., Krumbholz M., Titulaer M. J., Verschuuren J. J., Schumm F., Voltz R., Lambert-Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel Journal of Neuroimmunology 2008 204 1-2 136 139
16. Tani T., Tanaka K., Idezuka J., Nishizawa M., Regulatory T cells in paraneoplastic neurological syndromes Journal of Neuroimmunology 2008 196 1-2 166 169
17. Wirtz P. W., Roep B. O., Schreuder G. M. T., Van Doorn P. A., Van Engelen B. G. M., Kuks J. B., Twijnstra A., De Visser M., Visser L. H., Wokke J. H., Wintzen A. R., Verschuuren J. J., HLA class I and II in Lambert-Eaton myasthenic syndrome without associated tumor Human Immunology 2001 62 8 809 813 (Pubitemid 32703348)
18. Punga A. R., Nygren I., Askmark H., Stlberg E. V., Monozygous twins with neuromuscular transmission defects at opposite sides of the motor endplate Acta Neurologica Scandinavica 2009 119 3 207 211
19. Morris C. S., Esiri M. M., Marx A., Newsom-Davis J., Immunocytochemical characteristics of small cell lung carcinoma associated with the Lambert-Eaton myasthenic syndrome American Journal of Pathology 1992 140 4 839 845
20. Roberts A., Perera S., Lang B., Vincent A., Newsom-Davis J., Paraneoplastic myasthenic syndrome IgG inhibits 45Ca2+ flux in a human small cell carcinoma line Nature 1985 317 737 739 (Pubitemid 16223643)
21. Titulaer M. J., Soffietti R., Dalmau J., Gilhus N. E., Giometto B., Graus F., Grisold W., Honnorat J., Smitt P. A. E., Tanasescu R., Vedeler C. A., Voltz R., Verschuuren J. J. G. M., Screening for tumours in paraneoplastic syndromes: report of an EFNS task force European Journal of Neurology 2011 18 1 19 27
22. Titulaer M. J., Maddison P., Sont J. K., Clinical Dutch-English Lambert-Eaton myasthenic syndrome (LEMS) tumor-association prediction score accurately predicts small-cell lung cancer in the LEMS Journal of Clinical Oncology 2011;: 29 7 902 908
23. Mason W. P., Graus F., Lang B., Honnorat J., Delattre J. Y., Valldeoriola F., Antoine J. C., Rosenblum M. K., Rosenfeld M. R., Newsom-Davis J., Posner J. B., Dalmau J., Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome Brain 1997 120 8 1279 1300 (Pubitemid 27344700)
24. Romics L., McNamara B., Cronin P. A., O'Brien M. E., Relihan N., Redmond H. P., Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton myasthenic syndrome Irish Journal of Medical Science 2011 180 2 569 571
25. Lorenzoni P. J., Scola R. H., Lang B., Kay C. S. K., Teive H. A. G., Kowacs P. A., Werneck L. C., Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome Journal of the Neurological Sciences 2008 270 1-2 194 196
26. Skeie G. O., Apostolski S., Evoli A., Gilhus N. E., Illa I., Harms L., Hilton-Jones D., Melms A., Verschuuren J., Horge H. W., Guidelines for treatment of autoimmune neuromuscular transmission disorders European Journal of Neurology 2010 17 7 893 902
27. Argov Z., Management of myasthenic conditions: nonimmune issues Current Opinion in Neurology 2009 22 5 493 497
28. Spillane J., Beeson D. J., Kullmann D. M., Myasthenia and related disorders of the neuromuscular junction Journal of Neurology, Neurosurgery and Psychiatry 2010 81 8 850 857
29. Maddison P., Newsom-Davis J., Treatment for Lambert-Eaton myasthenic syndrome The Cochrane Library 2011 2, article CD003279
30. Weimer M. B., Wong J., Lambert-Eaton myastenic syndrome Current Treatment Options in Neurology 2009 11 77 84
31. Maddison P., McConville J., Farrugia M. E., The use of rituximab in myasthenia gravis and Lambert-Eaton myasthenic syndrome Journal of Neurology, Neurosurgery and Psychiatry 2011 82 6 671 673
32. Elovaara I., Apostolski S., van Doorn P., Gilhus N. E., Hietaharju A., Honkaniemi J., Van Schaik I. N., Scolding N., Srensen P., Udd B., EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases European Journal of Neurology 2008 15 9 893 908
33. Reuner U., Kamin G., Ramantani G., Reichmann H., Dinger J., Transient neonatal Lambert-Eaton syndrome Journal of Neurology 2008 255 11 1827 1828