Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: An observational study

Blood

Volumn 120, Issue 7, 2012, Pages 1510-1515

  Holzhauer, Susanne ^a   Goldenberg, Neil A ^b   Junker, Ralf ^c   Heller, Christine ^d   Stoll, Monika ^e   Manner, Daniela ^c,f   Mesters, Rolf ^f   Krümpel, Anne ^f   Stach, Michael ^f   Nowak Göttl, Ulrike ^c,f  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Mountain States Regional Hemophilia and Thrombosis Center   (United States)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e UNIVERSITY OF MÜNSTER   (Germany)

^f UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5; PROTEIN C; PROTEIN S; PROTHROMBIN;

ADOLESCENT; ADULT; AGE; ANTITHROMBIN DEFICIENCY; ARTICLE; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RELATIVE; RISK ASSESSMENT; SCHOOL CHILD; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

EID: 84865165553     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-01-405514     Document Type: Article

References (20)

1. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet. 1999;353(9159):1167-1173. (Pubitemid 29155221)
2. Middeldorp S, van Hylckama Vlieg A. Does thrombophilia testing help in the clinical management of patients? Br J Haematol. 2008;143(3):321-335.
3. Wu O, Greer IA. Is screening for thrombophilia cost-effective? Curr Opin Hematol. 2007;14(5):500-503. (Pubitemid 47457640)
4. Young G, Albisetti M, Bonduel M, et al. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Circulation. 2008;118(13):1373-1382.
5. Keeling D. Thrombophilia screening or screaming. J Thromb Haemost. 2010;8(6):1191-1192.
6. Tormene D, Pagnan A, Prandoni P, Simioni P. Screening for thrombophilia in children: a puzzling decision with unclear implications. J Thromb Haemost. 2004;2(7):1193-1194. (Pubitemid 40186094)
7. Calhoon MJ, Ross CN, Pounder E, Cassidy D, Manco-Johnson MJ, Goldenberg NA. High prevalence of thrombophilic traits in children with family history of thromboembolism. J Pediatr. 2010;157(3):485-489.
8. Lijfering WM, Brouwer JL, Veeger NJ, et al. Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. Blood. 2009;113(21):5314-5322.
9. Kromeyer-Hausschild K, Wabitsch M, Kunze D, et al. [Percentiles for body mass index for children and adolescents considering various samples from the German Population]. Monatsschr Kinderheilkd. 2001;149:807-818.
10. Cole TJ, Green PJ. Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992;11(10):1305-1319.
11. Michelson AD, Bovill E, Monagle P, Andrew M. Antithrombotic therapy in children. Chest. 1998;114(5 Suppl):748S-69S. (Pubitemid 28535794)
12. Haas S. Prevention of venous thromboembolism: recommendations based on the International Consensus and the American College of Chest Physicians Sixth Consensus Conference on Antithrombotic Therapy. Clin Appl Thromb Hemost. 2001;7(3):171-177. (Pubitemid 32574178)
13. Clagett GP, Anderson FA Jr, Heit J, Levine MN, Wheeler HB. Prevention of venous thromboembolism. Chest. 1995;108(4 Suppl):312S-334S.
14. Coppola A, Tufano A, Cerbone AM, Di Minno G. Inherited thrombophilia: implications for prevention and treatment of venous thromboembolism. Semin Thromb Hemost. 2009;35(7):683-694.
15. Sanson BJ, Simioni P, Tormene D, et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood. 1999;94(11):3702- 3706.
16. Segal JB, Brotman DJ, Necochea AJ, et al. Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. JAMA. 2009;301(23):2472-2485.
17. Mahmoodi BK, Brouwer JL, Ten Kate MK, et al. A prospective cohort study on the absolute risks of venous thromboembolism and predictive value of screening asymptomatic relatives of patients with hereditary deficiencies of protein S, protein C or antithrombin. J Thromb Haemost. 2010;8(6): 1193-1200.
18. Couturaud F, Kearon C. Predictors of thrombosis in relatives of patients with venous thromboembolism. Curr Opin Pulm Med. 2010;16(5):453-458.
19. Couturaud F, Leroyer C, Julian JA, et al. Factors that predict risk of thrombosis in relatives of patients with unprovoked venous thromboembolism. Chest. 2009;136(6):1537-1545.
20. Cohn DM, Roshani S, Middeldorp S. Thrombophilia and venous thromboembolism: implications for testing. Semin Thromb Hemost. 2007;33(6):573-581. (Pubitemid 47429309)