Predictors of thrombosis in relatives of patients with venous thromboembolism

Current Opinion in Pulmonary Medicine

Volumn 16, Issue 5, 2010, Pages 453-458

  Couturaud, Francis ^a   Kearon, Clive ^b  

^a Universite de Brest   (France)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

age; hereditary thrombophilia; venous thromboembolism

Indexed keywords

GENETIC PREDISPOSITION; HEREDITY; HUMAN; PREDICTOR VARIABLE; RELATIVE; REVIEW; RISK FACTOR; THROMBOPHILIA; THROMBOSIS; VENOUS THROMBOEMBOLISM;

FAMILY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PREDICTIVE VALUE OF TESTS; RISK FACTORS; THROMBOSIS; VENOUS THROMBOEMBOLISM;

EID: 77955267572     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e32833bde6b     Document Type: Review

References (29)

1. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999; 353:1167-1173.
2. Kearon C, Gent M, Hirsh J, et al. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med 1999; 340:901-907. (Pubitemid 29141050)
3. Kearon C, Ginsberg JS, Anderson DR, et al. Comparison of 1 month versus 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor. J Thromb Haemost 2004; 2:743-749.
4. Kearon C, Crowther M, Hirsh J. Management of patients with hereditary hypercoagulable disorders. Annu Rev Med 2000; 51:169-185.
5. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 1. Thromb Haemost 1996; 76:651-662.
6. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 2. Thromb Haemost 1996; 76:824-834.
7. Briet E, van der Meer FJM, Rosendaal FR, et al. The family history and inherited thrombophilia. Br J Haematol 1994; 87:348-352.
8. Bertina RM, KoelemanBPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369:64-67.
9. Poort SR, Rosendaal FR, Reitsma PH, et al. A common genetic variation in the 3-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698-3703.
10. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346:1133-1134.
11. Kearon C, Julian JA, Kovacs MJ, et al., ELATE Investigators. Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial. Blood 2008; 112:4432-4436.
12. Segal JB, Brotman DJ, Necochea AJ, et al. Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. J Am Med Assoc 2009; 301:2472-2485.
13. Baglin T, Luddington R, Brown K, Baglin C. Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. Lancet 2003; 138:19-25.
14. Christiansen SC, Cannegieter SC, Koster T, et al. Thrombophilia, clinical factors, and recurrent venous thrombotic events. J Am Med Assoc 2005; 293:2351-2361.
15. Couturaud F, Kearon C, Leroyer C, et al., for the Groupe dEtude de la Thrombose de Bretagne Occidentale (G.E.T.B.O). Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96:744-749.
16. Couturaud F, Leroyer C, Julian JA, et al. Factors that predict risk of thrombosis in relatives of patients with unprovoked venous thromboembolism. Chest 2009; 136:1537-1545.
17. Middeldorp S, Henkens CMA, Koopman MMW, et al. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. Ann Intern Med 1998; 128:15-20.
18. Simioni P, Sanson BJ, Prandoni P, et al. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1999; 81:198-202.
19. Lensen RP, Bertina RM, de Ronde H, et al. Venous thrombotic risk in family members of unselected individuals with factor V Leiden. Thromb Haemost 2000; 83:817-821.
20. Lijfering WM, Veeger NJ, Middeldorp S, et al. A lower risk of recurrent venous thrombosis in women compared with men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families. Blood 2009; 114:2031-2036.
21. Oger E. Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe dEtude de la Thrombose de Bretagne Occidentale. Thromb Haemost 2000; 83:657-660.
22. Heit JA, OFallon M, Petterson TM, et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism. A population-based study. Arch Intern Med 2002; 162:1245-1248.
23. Couturaud F, Leroyer C, Mottier D. Risk factors and clinical presentation of venous thromboembolism according to the age of relatives of patients with factor V Leiden. Thromb Haemost 2008; 99:793-794.
24. Van Sluis GL, Söhne M, Elkheir DY, et al. Family history and inherited thrombophilia. J Thromb Haemost 2006; 4:2182-2187.
25. Vandenbroucke JP, Koster T, Briet E, et al. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344:1453-1457.
26. Van Vlijmen EF, Brouwer JL, Veeger NJ, et al. Oral contraceptives and the absolute risk of venous thromboembolism in women with single or multiple thrombophilic defects: results from a retrospective family cohort study. Arch Intern Med 2007; 167:282-289.
27. Bucciarelli P, Rosendaal FR, Tripodi A, et al. Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study. Arterioscler Thromb Vasc Biol 1999; 19:1026-1033.
28. Van Boven HH, Vandenbroucke JP, Briët E, Rosendaal FR. Gene-gene and gene-environment interactions determine risk of thrombosis in families with inherited antithrombin deficiency. Blood 1999; 94:2590-2594.
29. Pomp ER, Lenselink AM, Rosendaal FR, Doggen CJ. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thromb Haemost 2008; 6:632-637.