Influence of circulating cytokines on prolactin during slow vs. fast exertional heat stress followed by active or passive recovery

Journal of Applied Physiology

Volumn 113, Issue 4, 2012, Pages 574-583

  Wright, Heather E ^a   McLellan, Tom M ^b   Friesen, Brian J ^a   Casa, Douglas J ^c   Kenny, Glen P ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b TM McLellan Research Inc   (Canada)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Core temperature; Neuroimmune response; Peripheral fatigue marker; Serotonin and dopamine interplay

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; PROLACTIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; COMPARATIVE STUDY; CONVALESCENCE; EXERCISE; EXERCISE TEST; FEMALE; HEART RATE; HEAT INJURY; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; MUSCLE FATIGUE; PATHOPHYSIOLOGY; PLASMA VOLUME; RUNNING; THERMOREGULATION; TIME; WALKING;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BODY TEMPERATURE REGULATION; CYTOKINES; EXERCISE TEST; FEMALE; HEART RATE; HEAT STRESS DISORDERS; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MUSCLE FATIGUE; PHYSICAL EXERTION; PLASMA VOLUME; PROLACTIN; RECOVERY OF FUNCTION; RUNNING; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WALKING; YOUNG ADULT;

EID: 84865146286     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00523.2012     Document Type: Article

References (66)

1. Balady GJ, Chaitman B, Driscoll D, Foster C, Froelicher E, Gordon N, Pate R, Rippe J, Bazzarre T. Recommendations for cardiovascular screening, staffing, and emergency policies at health/fitness facilities. Circulation 97: 2283-2293, 1998. (Pubitemid 28265396)
2. Besses GS, Burrow GN, Spaulding SW, Donabedian RK. Dopamine infusion acutely inhibits the TSH and prolactin response to TRH. J Clin Endocrinol Metab 41: 985-988, 1975.
3. Blomstrand E, Celsing F, Newsholme EA. Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta Physiol Scand 133: 115-121, 1988.
4. Bridge MW, Weller AS, Rayson M, Jones DA. Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function. Eur J Appl Physiol 89: 451-459, 2003. (Pubitemid 36806002)
5. Brisson GR, Audet A, Ledoux M, Matton P, Pellerin-Massicotte J, Peronnet F. Exercise-induced blood prolactin variations in trained adult males: a thermic stress more than an osmotic stress. Horm Res 23: 200-206, 1986. (Pubitemid 16104290)
6. Buckler JM. The relationship between changes in plasma growth hormone levels and body temperature occurring with exercise in man. Biomedicine 19: 193-197, 1973.
7. Cheuvront SN, Carter R 3rd, Kolka MA, Lieberman HR, Kellogg MD, Sawka MN. Branched-chain amino acid supplementation and human performance when hypohydrated in the heat. J Appl Physiol 97: 1275-1282, 2004. (Pubitemid 39299341)
8. Cox B, Kerwin RW, Lee TF, Pycock CJ. A dopamine-5-hydroxytryptamine link in the hypothalamic pathways which mediate heat loss in the rat. J Physiol 303: 9-21, 1980. (Pubitemid 10078569)
9. Cross MC, Radomski MW, VanHelder WP, Rhind SG, Shephard RJ. Endurance exercise with and without a thermal clamp: effects on leukocytes and leukocyte subsets. J Appl Physiol 81: 822-829, 1996. (Pubitemid 26303237)
10. CSEP. Physical Activity Readiness-Questionnaire Canadian Society for Exercise Physiology. Ottawa, Ontario, Canada: CSEP, 2002.
11. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37: 247-248, 1974.
12. Emmanouel DS, Fang VS, Katz AI. Prolactin metabolism in the rat: role of the kidney in degradation of the hormone. Am J Physiol Renal Fluid Electrolyte Physiol 240: F437-F445, 1981. (Pubitemid 11112956)
13. Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53: 1643-1648, 2004. (Pubitemid 38864744)
14. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16: 1335-1347, 2002. (Pubitemid 34913306)
15. Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev 80: 1523-1631, 2000.
16. Fuller A, Carter RN, Mitchell D. Brain and abdominal temperatures at fatigue in rats exercising in the heat. J Appl Physiol 84: 877-883, 1998. (Pubitemid 28110615)
17. Gagge AP, Stolwijk JA, Hardy JD. Comfort and thermal sensations and associated physiological responses at various ambient temperatures. Environ Res 1: 1-20, 1967.
18. Gaoua N, Racinais S, Grantham J, El Massioui F. Alterations in cognitive performance during passive hyperthermia are task dependent. Int J Hyperthermia 27: 1-9, 2011.
19. Gonzalez-Alonso J, Teller C, Andersen SL, Jensen FB, Hyldig T, Nielsen B. Influence of body temperature on the development of fatigue during prolonged exercise in the heat. J Appl Physiol 86: 1032-1039, 1999. (Pubitemid 29118028)
20. Green JM, Laurent CM, Bacon NT, Oneal EK, Davis JK, Bishop PA. Crossmodal session rating of perceived exertion response at low and moderate intensities. J Strength Cond Res 25: 1598-1604, 2011.
21. Halson SL, Quod MJ, Martin DT, Gardner AS, Ebert TR, Laursen PB. Physiological responses to cold water immersion following cycling in the heat. Int J Sports Physiol Perform 3: 331-346, 2008.
22. Hancock PA, Ross JM, Szalma JL. A meta-analysis of performance response under thermal stressors. Hum Factors 49: 851-877, 2007. (Pubitemid 47442108)
23. Hargreaves M. Physiological limits to exercise performance in the heat. J Sci Med Sport 11: 66-71, 2008. (Pubitemid 350266429)
24. Jentjens RL, Wagenmakers AJ, Jeukendrup AE. Heat stress increases muscle glycogen use but reduces the oxidation of ingested carbohydrates during exercise. J Appl Physiol 92: 1562-1572, 2002. (Pubitemid 34670912)
25. Leite LH, Rodrigues AG, Soares DD, Marubayashi U, Coimbra CC. Central fatigue induced by losartan involves brain serotonin and dopamine content. Med Sci Sports Exerc 42: 1469-1476, 2010.
26. Lenox RH, Kant GJ, Sessions GR, Pennington LL, Mougey EH, Meyerhoff JL. Specific hormonal and neurochemical responses to different stressors. Neuroendocrinology 30: 300-308, 1980. (Pubitemid 10147178)
27. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol 75: 668-674, 1993. (Pubitemid 23260206)
28. Low D, Cable T, Purvis A. Exercise thermoregulation and hyperprolactinaemia. Ergonomics 48: 1547-1557, 2005. (Pubitemid 43347824)
29. Low D, Purvis A, Reilly T, Cable NT. The prolactin responses to active and passive heating in man. Exp Physiol 90: 909-917, 2005. (Pubitemid 41659562)
30. Marx J, Hockberger R, Walls R. Rosen's Emergency Medicine: Concepts and Clinical Practice. St. Louis, MO: Mosby, 2010.
31. Meeusen R, Watson P, Hasegawa H, Roelands B, Piacentini MF. Central fatigue: the serotonin hypothesis and beyond. Sports Med 36: 881-909, 2006. (Pubitemid 44497464)
32. Melin B, Cure M, Pequignot JM, Bittel J. Body temperature and plasma prolactin and norepinephrine relationships during exercise in a warm environment: effect of dehydration. Eur J Appl Physiol Occup Physiol 58: 146-151, 1988.
33. Newsholme EA, Acworth IN, Blomstrand E. Advances In Myochemistry. London: John Libbey, 1987, p. 127-133.
34. Nieman DC. Immune response to heavy exertion. J Appl Physiol 82: 1385-1394, 1997. (Pubitemid 27203843)
35. Nybo L, Nielsen B. Hyperthermia and central fatigue during prolonged exercise in humans. J Appl Physiol 91: 1055-1060, 2001. (Pubitemid 32803896)
36. Nybo L, Secher NH, Nielsen B. Inadequate heat release from the human brain during prolonged exercise with hyperthermia. J Physiol 545: 697-704, 2002. (Pubitemid 36004397)
37. Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol 103: 1093-1098, 2007. (Pubitemid 47358897)
38. Pedersen BK, Bruunsgaard H, Klokker M, Kappel M, MacLean DA, Nielsen HB, Rohde T, Ullum H, Zacho M. Exercise-induced immunomodulation-possible roles of neuroendocrine and metabolic factors. Int J Sports Med 18, Suppl 1: S2-S7, 1997.
39. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80: 1055-1081, 2000. (Pubitemid 30452011)
40. Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Febbraio M, Saltin B. Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 24: 113-119, 2003. (Pubitemid 37323614)
41. Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Wolsk-Petersen E, Febbraio M. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc 63: 263-267, 2004. (Pubitemid 38787476)
42. Pedersen BK, Steensberg A, Schjerling P. Muscle-derived interleukin-6: possible biological effects. J Physiol 536: 329-337, 2001. (Pubitemid 32976115)
43. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 98: 1154-1162, 2005. (Pubitemid 40396484)
44. Pitsiladis YP, Strachan AT, Davidson I, Maughan RJ. Hyperprolactinaemia during prolonged exercise in the heat: evidence for a centrally mediated component of fatigue in trained cyclists. Exp Physiol 87: 215-226, 2002. (Pubitemid 34257036)
45. Proulx CI, Ducharme MB, Kenny GP. Effect of water temperature on cooling efficiency during hyperthermia in humans. J Appl Physiol 94: 1317-1323, 2003. (Pubitemid 36348806)
46. Rhind SG, Gannon GA, Shephard RJ, Buguet A, Shek PN, Radomski MW. Cytokine induction during exertional hyperthermia is abolished by core temperature clamping: neuroendocrine regulatory mechanisms. Int J Hyperthermia 20: 503-516, 2004. (Pubitemid 39004121)
47. Robson-Ansley PJ, de Milander L, Collins M, Noakes TD. Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners. Can J Appl Physiol 29: 411-418, 2004. (Pubitemid 39107948)
48. Rodrigues AG, Soares DD, Marubayashi U, Coimbra CC. Heat loss during exercise is related to serotonin activity in the preoptic area. Neuroreport 20: 804-808, 2009.
49. Sakurada S, Hales Jr. A role for gastrointestinal endotoxins in enhancement of heat tolerance by physical fitness. J Appl Physiol 84: 207-214, 1998. (Pubitemid 28065130)
50. Schlader ZJ, Raman A, Morton RH, Stannard SR, Mundel T. Exercise modality modulates body temperature regulation during exercise in uncompensable heat stress. Eur J Appl Physiol 111: 757-766, 2011.
51. Selkirk GA, McLellan TM, Wright HE, Rhind SG. Mild endotoxemia, NF-kappaB translocation, and cytokine increase during exertional heat stress in trained and untrained individuals. Am J Physiol Regul Integr Comp Physiol 295: R611-R623, 2008.
52. Serri O, Chik CL, Ur E, Ezzat S. Diagnosis and management of hyperprolactinemia. CMAJ 169: 575-581, 2003. (Pubitemid 37174600)
53. Shiraki K, Konda N, Sagawa S. Esophageal and tympanic temperature responses to core blood temperature changes during hyperthermia. J Appl Physiol 61: 98-102, 1986. (Pubitemid 16055664)
54. Siri WE. Gross Composition of the Body. New York: Academic, 1956, p. 239-280.
55. Soares DD, Coimbra CC, Marubayashi U. Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area. Neurosci Lett 415: 274-278, 2007. (Pubitemid 46402960)
56. St. Clair Gibson A, Noakes TD. Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med 38: 797-806, 2004. (Pubitemid 39611568)
57. Struder HK, Hollmann W, Platen P, Wostmann R, Ferrauti A, Weber K. Effect of exercise intensity on free tryptophan to branched-chain amino acids ratio and plasma prolactin during endurance exercise. Can J Appl Physiol 22: 280-291, 1997.
58. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics Exerc Immunol Rev 8: 6-48, 2002.
59. Taylor NA, Caldwell JN, Van den Heuvel AM, Patterson MJ. To cool, but not too cool: that is the question-immersion cooling for hyperthermia. Med Sci Sports Exerc 40: 1962-1969, 2008.
60. Tikuisis P, McLellan TM, Selkirk G. Perceptual versus physiological heat strain during exercise-heat stress. Med Sci Sports Exerc 34: 1454-1461, 2002. (Pubitemid 35006817)
61. Turnbull AV, Rivier CL. Regulation of the hypothalamic-pituitaryadrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79: 1-71, 1999. (Pubitemid 29056948)
62. Van de Kar LD, Rittenhouse PA, Li Q, Levy AD. Serotonergic regulation of renin and prolactin secretion. Behav Brain Res 73: 203-208, 1996. (Pubitemid 26008783)
63. Watson P, Shirreffs SM, Maughan RJ. The effect of acute branchedchain amino acid supplementation on prolonged exercise capacity in a warm environment. Eur J Appl Physiol 93: 306-314, 2004. (Pubitemid 39534633)
64. Wright HE, Selkirk GA, McLellan TM. HPA and SAS responses to increasing core temperature during uncompensable exertional heat stress in trained and untrained males. Eur J Appl Physiol 108: 987-997, 2010.
65. Wright HE, Selkirk GA, Rhind SG, McLellan TM. Peripheral markers of central fatigue in trained and untrained during uncompensable heat stress. Eur J Appl Physiol 112: 1047-1057, 2012.
66. Young SN. Nutrition and the Brain. New York: Raven, 1986.