IASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes

Apoptosis

Volumn 17, Issue 8, 2012, Pages 777-783

  Cai, Yun ^a   Qiu, Shi ^a   Gao, Xing ^a   Gu, Shou Zhi ^a,b   Liu, Ze Jun ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SEIREI CHRISTOPHER UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bax; IASPP; P63; P73; PUMA Abbreviations ASPP Apoptosis stimulating protein of p53 iASPP Inhibitory member of the ASPP family

Indexed keywords

BETA ACTIN; PROTEIN BAX; PROTEIN DNAJ; PROTEIN IASPP; PROTEIN P53; PROTEIN P63; PROTEIN P73; PUMA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; RNA INTERFERENCE; TRANSACTIVATION; TUMOR CELL; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; REPRESSOR PROTEINS; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84865139134     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0728-z     Document Type: Article

References (34)

1. Vousden KH, Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2:594-604 (Pubitemid 37328926)
2. Vousden KH (2005) P53 and PUMA: a deadly duo. Science 309:1685-1686 (Pubitemid 41285928)
3. Lu X (2005) p53: a heavily dictated dictator of life and death. Curr Opin Genet Dev 15:27-33 (Pubitemid 40127628)
4. Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S et al (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8:781-794 (Pubitemid 33030212)
5. Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK et al (2003) iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 33:162-167 (Pubitemid 36177067)
6. Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X (2004) ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 24:1341-1350 (Pubitemid 38112194)
7. Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A et al (2006) iASPP preferentially binds p53 prolinerich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet 38:1133-1141 (Pubitemid 44470358)
8. Liu ZJ, Lu X, Zhong S (2005) ASPP-Apoptotic specific regulator of p53. Biochim Biophys Acta 1756:77-80
9. Sullivan A, Lu X (2007) ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer 96:196-200 (Pubitemid 46160620)
10. Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S et al (2004) The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Oncogene 23: 9006-9016
11. Bell HS, Ryan KM (2008) iASPP inhibition: increased options in targeting the p53 family for cancer therapy. Cancer Res 68: 4959-4962
12. Chen J, Xie F, Zhang L, Jiang WG (2010) iASPP is overexpressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway. BMC Cancer 10:694
13. Laska MJ, Vogel UB, Jensen UB, Nexo BA (2010) p53 and PPP1R13L(alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses. Biochim Biophys Acta 1800:1231
14. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53 (Pubitemid 21917115)
15. p53 mutation database. Available from: http://p53.free.fr/. Accessed 25 Mar 2012
16. Slee EA, O'Connor DJ, Lu X (2004) To die or not to die: how does p53 decide. Oncogene 23:2809-2818 (Pubitemid 38638844)
17. Chikh A, Matin RN, Senatore V, Hufbauer M, Lavery D, Raimondi C et al (2011) iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J 30:4261
18. Liu ZJ, Gao X, Cai Y, Yang X, Fu XL, Chen J et al (2009) Construction of a full-length iASPP Expression plasmid pcDNA3.1(?)/iASPP and its biological activity. Plasmid 62: 10-15
19. Liu ZJ, Cai Y, Hou L, Gao X, Xin HM, Lu X et al (2008) Effect of RNA interference of iASPP on the apoptosis in MCF-7 breast cancer cells. Cancer Invest 26:878-882
20. Liu ZJ, Xin HM, Chen J, Lu X, Zhong S, Gu SZ et al (2007) A new strategy to resume the apoptosis activity of p53 in leukemia cell lines retaining wild-type p53. Leukemia Res 31:1156-1158
21. Jost CA, Marin MC, Kaelin WG Jr (1997) p73 is a human p53-related protein that can induce apoptosis. Nature 389:191-194 (Pubitemid 27400602)
22. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dotsch V et al (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominantnegative activities. Mol Cell 2:305-316 (Pubitemid 128379271)
23. Robinson RA, Lu X, Jones EY, Siebold C (2008) Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63 and p73. Structure 16:259-268 (Pubitemid 351215211)
24. Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKcon F et al (2002) p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416:560-564 (Pubitemid 34288861)
25. Murray-Zmijewski F, Lane DP, Bourdon JC (2006) P53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 13:962-972
26. Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV (2008) Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax. Nucleic Acids Res 36:5139-5151
27. Liu ZJ, Zhang Y, Zhang XB, Yang X (2004) Abnormal mRNA expression of ASPP members in leukemia cell lines. Leukemia 18:880 (Pubitemid 38500212)
28. Zhang X, Wang M, Zhou C, Chen S, Wang J (2005) The expression of iASPP in acute leukemias. Leukemia Res 29: 179-183 (Pubitemid 39647513)
29. Lu B, Guo H, Zhao J, Wang C, Wu G, Pang M et al (2010) Increased expression of iASPP, regulated by hepatitis B virus X protein-mediated NF-jB activation, in hepatocellular carcinoma. Gastroenterology 139:2183-2194
30. Liu WK, Jiang XY, Ren JK, Zhang ZX (2010) Expression pattern of the ASPP family members in endometrial endometrioid adenocarcinoma. Onkologie 33:500-503
31. Pinto EM, Musolino NR, Cescato VA, Soares IC, Wakamatsu A, de Oliveira E et al (2010) iASPP: a novel protein involved in pituitary tumorigenesis? Front Horm Res 38:70-76
32. Olivier M, Hollstein M, Hainaut P (2010) TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2:a001008
33. Soussi T, Kato S, Levy PP, Ishioka C (2005) Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum Mutat 25:6-17 (Pubitemid 40075908)
34. Berglind H, Pawitan Y, Kato S, Ishioka C, Soussi T (2008) Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination. Cancer Biol Ther 7:699-708