Appropriate antibiotic dosing in severe sepsis and acute renal failure: Factors to consider

Critical Care

Volumn 15, Issue 4, 2011, Pages

  González de Molina, Francisco J ^a   Ferrer, Ricard ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; ANTIINFECTIVE AGENT; BETA LACTAM;

ACUTE KIDNEY FAILURE; BACTERICIDAL ACTIVITY; CONTINUOUS RENAL REPLACEMENT THERAPY; CRITICALLY ILL PATIENT; DIALYSATE; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE REDUCTION; DRUG ELIMINATION; HEMOFILTRATION; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; MINIMUM INHIBITORY CONCENTRATION; NOTE; PRIORITY JOURNAL; RISK FACTOR; SEPSIS; WEIGHT; FEMALE; MALE; METHODOLOGY; RENAL REPLACEMENT THERAPY; SEPTIC SHOCK;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; FEMALE; HUMANS; MALE; RENAL REPLACEMENT THERAPY; SHOCK, SEPTIC;

EID: 84865127593     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10298     Document Type: Note

References (15)

1. Seyler L, Cotton F, Taccone FS, De Backer D, Macours P, Vincent JL, Jacobs F. Recommended beta-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care 2011, 15:R137. 10.1186/cc10257, 21649882.
2. Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I, Aldabo-Pallas T, Cayuela-Dominguez A, Marquez-Vacaro JA, Carbajal-Guerrero J, Garcia-Garmendia JL. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother 2008, 61:436-441.
3. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, . Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005, 294:813-818. 10.1001/jama.294.7.813, 16106006, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators.
4. Roberts JA, Lipman J. Pharmacokinetic issues for antibiotics in the critically ill patient. Crit Care Med 2009, 37:840-851. 10.1097/CCM.0b013e3181961bff, 19237886.
5. Trotman RL, Williamson JC, Shoemaker DM, Salzer WL. Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy. Clin Infect Dis 2005, 41:1159-1166. 10.1086/444500, 16163635.
6. Schetz M, Ferdinande P, Van den Berghe G, Verwaest C, Lauwers P. Pharmacokinetics of continuous renal replacement therapy. Intensive Care Med 1995, 21:612-620. 10.1007/BF01700172, 7593908.
7. Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl 1998, 66:S165-168.
8. Bugge JF. Pharmacokinetics and drug dosing adjustments during continuous venovenous hemofiltration or hemodiafiltration in critically ill patients. Acta Anaesthesiol Scand 2001, 45:929-934. 10.1034/j.1399-6576.2001.450802.x, 11576041.
9. Bagshaw SM, Bellomo R, Devarajan P, Johnson C, Karvellas CJ, Kutsiogiannis DJ, Mehta R, Pannu N, Romanovsky A, Sheinfeld G, Taylor S, Zappitelli M, Gibney RT. Review article: renal support in critical illness. Can J Anaesth 2010, 57:999-1013. 10.1007/s12630-010-9376-3, 20931311.
10. Basso F, Ricci Z, Cruz D, Ronco C. International survey on the management of acute kidney injury in critically ill patients: year 2007. Blood Purif 2010, 30:214-220. 10.1159/000320126, 20948196.
11. Pea F, Viale P, Pavan F, Furlanut M. Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin Pharmacokinet 2007, 46:997-1038. 10.2165/00003088-200746120-00003, 18027987.
12. Cerda J, Ronco C. Modalities of continuous renal replacement therapy: technical and clinical considerations. Semin Dial 2009, 22:114-122. 10.1111/j.1525-139X.2008.00549.x, 19426413.
13. DeRyke CA, Lee SY, Kuti JL, Nicolau DP. Optimising dosing strategies of antibacterials utilising pharmacodynamic principles: impact on the development of resistance. Drugs 2006, 66(1):1-14.
14. Mouton JW, Vinks AA. Continuous infusion of beta-lactams. Curr Opin Crit Care 2007, 13:598-606. 10.1097/MCC.0b013e3282e2a98f, 17762242.
15. Joukhadar C, Frossard M, Mayer BX, Brunner M, Klein N, Siostrzonek P, Eichler HG, Muller M. Impaired target site penetration of betalactams may account for therapeutic failure in patients with septic shock. Crit Care Med 2001, 29:385-391. 10.1097/00003246-200102000-00030, 11246321.