A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: Hyperandrogenism induces epigenetic alterations in the granulosa cells

Journal of Molecular Medicine

Volumn 90, Issue 8, 2012, Pages 911-923

  Qu, Fan ^a,b   Wang, Fang Fang ^a   Yin, Rong ^a   Ding, Guo Lian ^a   El prince, Mohamed ^a   Gao, Qian ^a,c   Shi, Bi Wei ^a,b   Pan, Hui Hui ^a,b   Huang, Yi Ting ^a   Jin, Min ^a,b   Leung, Peter K ^a,d   Sheng, Jian Zhong ^a,b,c   Huang, He Feng ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Acetylation; Hyperandrogenism; Methylation; Ovarian dysfunction; Polycystic ovary syndrome

Indexed keywords

ANDROSTANOLONE; HISTONE H3; LYSINE; MESSENGER RNA; PROTEIN P21;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; FEMALE; FEMALE INFERTILITY; GENE; GRANULOSA CELL; HDAC3 GENE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HYPERANDROGENISM; NCOR1 GENE; NONHUMAN; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; PPARG1 GENE; PROMOTER REGION; RAT; SPRAGUE DAWLEY RAT; UTERINE TUBE OCCLUSION;

ACETYLATION; ANIMALS; ANTI-MULLERIAN HORMONE; CELLS, CULTURED; DIHYDROTESTOSTERONE; DNA METHYLATION; FEMALE; GRANULOSA CELLS; HISTONE DEACETYLASES; HUMANS; HYPERANDROGENISM; NUCLEAR RECEPTOR CO-REPRESSOR 1; POLYCYSTIC OVARY SYNDROME; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84865126089     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0881-4     Document Type: Article

References (29)

1. Norman RJ, Dewailly D, Legro RS, Hickey TE (2007) Polycystic ovary syndrome. Lancet 370:685-697 (Pubitemid 47285318)
2. Xita N, Tsatsoulis A (2006) Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies. J Clin Endocrinol Metab 91:1660-1666
3. Dumesic DA, Abbott DH, Padmanabhan V (2007) Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord 8:127-141 (Pubitemid 47434646)
4. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R (2011) Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 7:219-231
5. Froment P, Gizard F, Staels B, Dupont J, Monget P (2005) A role of PPARgamma in reproduction? Med Sci (Paris) 21:507-511
6. Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS (1997) Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 82:2108-2116 (Pubitemid 27287569)
7. Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Fereshetian AG, O'Keefe M, Ghazzi MN (2001) Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab 86:1626-1632 (Pubitemid 32374915)
8. Brettenthaler N, De Geyter C, Huber PR, Keller U (2004) Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 89:3835-3840 (Pubitemid 39071481)
9. Sepilian V, Nagamani M (2005) Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance. J Clin Endocrinol Metab 90:60-65 (Pubitemid 40116634)
10. Gao Z, He Q, Peng B, Chiao PJ, Ye J (2006) Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. J Biol Chem 281:4540-4547 (Pubitemid 43847886)
11. Guenther MG, Barak O, Lazar MA (2001) The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol Cell Biol 21:6091-6101 (Pubitemid 34263509)
12. Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E et al (2000) Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102:753-763
13. Bhaskara S, Chyla BJ, Amann JM, Knutson SK, Cortez D, Sun ZW, Hiebert SW (2008) Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30:61-72 (Pubitemid 351470157)
14. Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bucan M, Ahima RS, Kaestner KH, Lazar MA (2008) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456:997-1000
15. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41-47
16. Nikolettos N, Kupker W, Al-Hasani S, Demirel LC, Schopper B, Sturm R, Diedrich K (2000) ICSI outcome in patients of 40 years age and over: a retrospective analysis. Eur J Obstet Gynecol Reprod Biol 91:177-182 (Pubitemid 30408327)
17. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF (2010) Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod 25:1441-1450
18. Seto-Young D, Avtanski D, Strizhevsky M, Parikh G, Patel P, Kaplun J, Holcomb K, Rosenwaks Z, Poretsky L (2007) Interactions among peroxisome proliferator activated receptorgamma, insulin signaling pathways, and steroidogenic acute regulatory protein in human ovarian cells. J Clin Endocrinol Metab 92:2232-2239 (Pubitemid 46997128)
19. Sayasith K, Bouchard N, Dore M, Sirois J (2008) Regulation of bovine tumor necrosis factor alpha induced protein 6 in ovarian follicles during the ovulatory process and promoter activation in granulosa cells. Endocrinology 149:6213-6225
20. Roberts R, Stark J, Iatropoulou A, Becker DL, Franks S, Hardy K (2004) Energy substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation. Bio Reprod 71:199-209 (Pubitemid 38915326)
21. Tamura N, Kurabayashi T, Nagata H,Matsushita H,Yahata T, Tanaka K (2005) Effects of testosterone on cancellous bone, marrow adipocytes, and ovarian phenotype in a young female rat model of polycystic ovary syndrome. Fertil Steril 84(Suppl 2):1277-1284 (Pubitemid 41396555)
22. Doi SA, Al-Zaid M, Towers PA, Scott CJ, Al-Shoumer KA (2006) Steroidogenic alterations and adrenal androgen excess in PCOS. Steroids 71:751-759 (Pubitemid 44081934)
23. Olek A, Oswald J, Walter J (1996) A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res 24:5064-5066 (Pubitemid 27007919)
24. Pigny P, Jonard S, Robert Y, Dewailly D (2006) Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome. J Clin Endocrinol Metab 91:941-945 (Pubitemid 43357762)
25. Shalev E, Goldman S, Ben-Shlomo I (2001) The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 in luteinized granulosa cells: comparison between women with PCOS and normal ovulatory women. Mol Hum Reprod 7:325-331 (Pubitemid 32288321)
26. Karagianni P, Wong J (2007) HDAC3: taking the SMRT-NCoRrect road to repression. Oncogene 26:5439-5449 (Pubitemid 47255926)
27. Sun F, Yu J (2000) The effect of a special herbal tea on obesity and anovulation in androgen-sterilized rats. Proc Soc Exp Biol Med 223:295-301 (Pubitemid 30337785)
28. Escobar-Morreale HF, AsuncionM, CalvoRM, Sancho J, San Millan JL (2001) Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies. Eur J Endocrinol 145:619-624 (Pubitemid 33069338)
29. Koskinen P, Penttila TA, Anttila L, Erkkola R, Irjala K (1996) Optimal use of hormone determinations in the biochemical diagnosis of the polycystic ovary syndrome. Fertil Steril 65:517-522 (Pubitemid 26069105)