Different susceptibility of rat pancreatic alpha and beta cells to hypoxia

Histochemistry and Cell Biology

Volumn 137, Issue 6, 2012, Pages 801-810

  Bloch, Konstantin ^a   Vennäng, Julia ^a   Lazard, Daniel ^a   Vardi, Pnina ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Alpha cells; Beta cells; Hypoxia; Pancreatic islets

Indexed keywords

GLUCAGON; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CELL VIABILITY; GLUCAGON RELEASE; HYPOXIA; INSULIN RELEASE; MALE; NICK END LABELING; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS;

ANIMALS; APOPTOSIS; CELL HYPOXIA; GLUCAGON; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84865123386     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-012-0925-4     Document Type: Article

References (34)

1. Bloch K, Shichman E, Vorobeychik M, Bloch D, Vardi P (2007) Catalase expression in pancreatic alpha cells of diabetic and non diabetic mice. Histochem Cell Biol 127:227-232 (Pubitemid 46147277)
2. Bloch K, Bloch O, Tarasenko I, Lazard D, Rapoport M, Vardi P (2011) A strategy for the engineering of insulin producing cells with a broad spectrum of defense properties. Biomaterials 32: 1816-1825
3. Bohman S, King AJ (2008) Islet alpha cell number is maintained in microencapsulated islet transplantation. Biochem Biophys Res Commun 377:729-733
4. Bolli G, de Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE (1983) Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-141 (Pubitemid 13180346)
5. Bosco D, Armanet M, Morel P, Niclauss N, Sgroi A, Muller YD, Giovannoni L, Parnaud G, Berney T (2010) Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 59:1202-1210
6. Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare- Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ (2009) Deletion of the von Hippel- Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119:125-135
7. Carlsson PO, Palm F, Andersson A, Liss P (2001) Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 50:489-495 (Pubitemid 32195212)
8. Chung CH, Hao E, Piran R, Keinan E, Levine F (2010) Pancreatic b-cell neogenesis by direct conversion from mature a-cells. Stem Cells 28:1630-1638
9. Dionne KE, Colton CK, Yarmush ML (1993) Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans. Diabetes 42:12-21 (Pubitemid 23013790)
10. Elayat AA, el-Naggar MM, Tahir M (1995) An immunocytochemical and morphometric study of the rat pancreatic islets. J Anat 186: 629-637
11. Gehrmann W, Elsner M, Lenzen S (2010) Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic b-cells. Diabetes Obes Metab 2(suppl):149-158
12. Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH (1973) Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 182:171-173
13. Greijer AE, van der Wall E (2004) The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57:1009-1014 (Pubitemid 39331346)
14. Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28:84-116 (Pubitemid 46220851)
15. Kendall DM, Teuscher AU, Robertson RP (1997) Defective glucagon secretion during sustained hypoglycemia following successful islet allo- and autotransplantation in humans. Diabetes 46:23-27 (Pubitemid 27009944)
16. King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC (2007) Normal relationship of beta- and non-betacells not needed for successful islet transplantation. Diabetes 56:2312-2318 (Pubitemid 47358238)
17. Ko SH, Ryu GR, Kim SB, Ahn YB, Yoon KH, Kaneto H, Ha H, Kim YS, Song KH (2008) Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. Transplantation 85:323-330 (Pubitemid 351322754)
18. Kurose T, Tsuda K, Ishida H, Tsuji K, Okamoto Y, Tsuura Y, Kato S, Usami M, Imura H, Seino Y (1992) Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro. Diabetologia 35: 1035-1041
19. Lai Y, Brandhorst H, Hossain H, Bierhaus A, Chen C, Bretzel RG, Linn T (2009) Activation of NFjB dependent apoptotic pathway in pancreatic islet cells by hypoxia. Islets 1:19-25
20. Lau J, Jansson L, Carlsson PO (2006) Islets transplanted intraportally into the liver are stimulated to insulin and glucagon release exclusively through the hepatic artery. Am J Transplant 6: 967-975 (Pubitemid 44356646)
21. Lefebvre PJ (1995) Glucagon and its family revisited. Diabetes Care 18:715-730
22. Lenzen S (2008) Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans 36:343-347
23. Li Z, Karlsson FA, Sandler S (2000) Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol 165:93-99 (Pubitemid 30210569)
24. Mathis D, Vence L, Benoist C (2001) Beta-cell death during progression to diabetes. Nature 414:792-798
25. Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M (2002) Apoptosis in hypoxic human pancreatic islets correlates with HIF-1 alpha expression. FASEB J 16:745-747
26. Orci L, Unger RH (1975) Functional subdivision of islets of Langerhans and possible role of D cells. Lancet 2:1243-1244
27. Paty BW, Ryan EA, Shapiro AM, Lakey JR, Robertson RP (2002) Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51:3428-3434 (Pubitemid 35403446)
28. Puri S, Cano DA, Hebrok M (2009) A role for von Hippel-Lindau protein in pancreatic beta-cell function. Diabetes 58:433-441
29. Rahier J, Goebbels RM, Henquin JC (1983) Cellular composition of the human diabetic pancreas. Diabetologia 24:366-371 (Pubitemid 13092224)
30. Reddy S, Pathipati P, Bai Y, Robinson E, Ross JM (2005) Histopathological changes in insulin, glucagon and somatostatin cells in the islets of NOD mice during cyclophosphamideaccelerated diabetes: a combined immunohistochemical and histochemical study. J Mol Histol 36:289-300 (Pubitemid 41414406)
31. Shapiro AM, Ricordi C, Hering BJ et al (2006) International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355:1318-1330 (Pubitemid 44465460)
32. Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL (2010) Conversion of adult pancreatic alpha-cells to betacells after extreme beta-cell loss. Nature 464:1149-1154
33. Unger RH, Orci L (1977) Role of glucagon in diabetes. Arch Intern Med 137:482-491 (Pubitemid 9032901)
34. Unger RH, Aguilar-Parada E, Muller WA, Eisentraut AM (1970) Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 49:837-848