Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 4, 2012, Pages

  Atchison, Douglas K ^a,b   Westrick, Elizabeth ^a   Szandzik, David L ^a   Gordish, Kevin L ^a,b   Beierwaltes, William H ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Calcium; Hypercalcemia; Hyperparathyroidism; Parathyroid hormone receptor

Indexed keywords

CALCIUM ION; DRINKING WATER; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN; SODIUM CHLORIDE; SODIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY WEIGHT; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CALORIC INTAKE; CONTROLLED STUDY; CREATININE CLEARANCE; FLUID INTAKE; FOOD INTAKE; HYPERCALCEMIA; HYPERPARATHYROIDISM; IN VIVO STUDY; KIDNEY CALCIFICATION; KIDNEY PARENCHYMA; MALE; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; SALT INTAKE; SODIUM BLOOD LEVEL; SODIUM RESTRICTION; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; URINE OSMOLALITY;

ANIMALS; ANOREXIA; BODY WEIGHT; CALCIUM; KIDNEY; MALE; PARATHYROID HORMONE-RELATED PROTEIN; RATS; RENIN; SODIUM CHLORIDE, DIETARY;

EID: 84865122086     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00020.2012     Document Type: Article

References (47)

1. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Jr, Kronenberg HM, Segre GV. Expression cloning of a common receptor for osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89: 2732-2736, 1992.
2. Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A. Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3. Psychoneuroendocrinology 35: 1178-1186, 2010.
3. Atchison DK, Harding P, Beierwaltes WH. Hypercalcemia reduces plasma renin via parathyroid hormone, renal interstitial calcium, and the calcium-sensing receptor. Hypertension 58: 604-610, 2011.
4. Atchison DK, Harding P, Beierwaltes WH. Parathyroid Hormone Related Protein Dissociates Increased cAMP from Renin Secretion in Mouse Juxtaglomerular Cells (Abstract No. 24782). Proceedings of the American Society of Nephrology, Renal Week, Philadelphia, PA, 2011.
5. Beierwaltes WH. Macula densa stimulation of renin is reversed by selective inhibition of neuronal nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 272: R1359-R1364, 1997.
6. Bernini G, Moretti A, Lonzi S, Bendinelli C, Miccoli P, Salvetti A. Renin-angiotensin-aldosterone system in primary hyperparathyroidism before and after surgery. Metabolism 48: 298-300, 1999.
7. Body JJ, Dumon JC, Thirion M, Cleeren A. Circulating PTHrP concentrations in tumor-induced hypercalcemia: influence on the response to bisphosphonate and changes after therapy. J Bone Miner Res 8: 701-706, 1993.
8. Brinton GS, Jubiz W, Lagerquist LD. Hypertension in primary hyperparathyroidism: the role of the renin-angiotensin system. J Clin Endocrinol Metab 41: 1025-1029, 1975.
9. Broulik PD, Horký K, Pacovský V. Blood pressure in patients with primary hyperparathyroidism before and after parathyroidectomy. Exp Clin Endocrinol 86: 346-352, 1985.
10. Brown JJ, Davies DL, Lever AF, Robertson JI. Influence of sodium deprivation and loading on the plasma renin in man. J Physiol 173: 408-419, 1964.
11. Castrop H, Schweda F, Schumacher K, Wolf K, Kurtz A. Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion. J Am Soc Nephrol 12: 867-874, 2001.
12. Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Pharmacol 134: 1113-1136, 2001.
13. Fukamizu A, Sugimura K, Takimoto E, Sugiyama F, Seo MS, Takahashi S, Hatae T, Kajiwara N, Yagami K, Murakami K. Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes. J Biol Chem 268: 11617-11621, 1993.
14. Gennari C, Nami R, Gonnelli S. Hypertension and primary hyperparathyroidism: the role of adrenergic and renin-angiotensin-aldosterone systems. Miner Electrolyte Metab 21: 77-81, 1995.
15. Gurney H, Grill V, Martin TJ. Parathyroid hormone-related protein and response to pamidronate in tumour-induced hypercalcaemia. Lancet 341: 1611-1613, 1993.
16. Harding P, Carretero OA, Beierwaltes WH. Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics. J Hypertens 18: 1107-1113, 2000.
17. Harding P, Sigmon DH, Alfie ME, Huang PL, Fishman MC, Beierwaltes WH, Carretero OA. Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet. Hypertension 29: 297-302, 1997.
18. Hashimoto H, Azuma Y, Kawasaki M, Fujihara H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Ueta Y. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides. Clin Cancer Res 13: 292-298, 2007.
19. Iguchi H, Onuma E, Sato K, Sato K, Ogata E. Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen. Int J Cancer 94: 24-27, 2001.
20. Jaeger P, Jones W, Kashgarian M, Baron R, Clemens TL, Segre GV, Hayslett JP. Animal model of primary hyperparathyroidism. Am J Physiol Endocrinol Metab 252: E790-E798, 1987.
21. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT Jr, Kronenberg HM, Segre GV. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 1024-1026, 1991.
22. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92: 2735-2739, 1995.
23. Komatsu Y, Imai Y, Itoh F, Kojima M, Isaji M, Shibata N. Rat model of the hypercalcaemia induced by parathyroid hormone-related protein: characteristics of three bisphosphonates. Eur J Pharmacol 507: 317-324, 2005.
24. Kotchen TA, Galla JH, Luke RG. Contribution of chloride to the inhibition of plasma renin by sodium chloride in the rat. Kidney Int 13: 201-207, 1978.
25. Kovács L, Góth MI, Szabolcs I, Dohán O, Ferencz A, Szilágyi G. The effect of surgical treatment on secondary hyperaldosteronism and relative hyperinsulinemia in primary hyperparathyroidism. Eur J Endocrinol 138: 543-547, 1998.
26. Lorenz JN, Weihprecht H, Schnermann J, Skøtt O, Briggs JP. Renin release from isolated juxtaglomerular apparatus depends on macula densa chloride transport. Am J Physiol Renal Fluid Electrolyte Physiol 260: F486-F493, 1991.
27. Massfelder T, Stewart AF, Endlich K, Soifer N, Judes C, Helwig JJ. Parathyroid hormone-related protein detection and interaction with NO and cyclic AMP in the renovascular system. Kidney Int 50: 1591-1603, 1996.
28. Meng X, Dai X, Liao TD, D'Ambrosio M, Wang F, Yang JJ, Yang XP. Dose-dependent toxic effects of high-dose estrogen on renal and cardiac injury in surgically postmenopausal mice. Life Sci 88: 178-186, 2011.
29. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, Martin TJ. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84: 5048-5052, 1987.
30. Onuma E, Tsunenari T, Saito H, Sato K, Yamada-Okabe H, Ogata E. Parathyroid hormone-related protein (PTHrP) as a causative factor of cancer-associated wasting: possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts. Int J Cancer 116: 471-478, 2005.
31. Richards AM, Espiner EA, Nicholls MG, Ikram H, Hamilton EJ, Maslowski AH. Hormone, calcium and blood pressure relationships in primary hyperparathyroidism. J Hypertens 6: 747-752, 1988.
32. Rodan SB, Noda M, Wesolowski G, Rosenblatt M, Rodan GA. Comparison of postreceptor effects of 1-34 human hypercalcemia factor and 1-34 human parathyroid hormone in rat osteosarcoma cells. J Clin Invest 81: 924-927, 1988.
33. Salahudeen AK, Thomas TH, Sellars L, Tapster S, Keavey P, Farndon JR, Johnston ID, Wilkinson R. Hypertension and renal dysfunction in primary hyperparathyroidism: effect of parathyroidectomy. Clin Sci (Lond) 76: 289-296, 1989.
34. Saussine C, Judes C, Massfelder T, Musso MJ, Simeoni U, Hannedouche T, Helwig JJ. Stimulatory action of parathyroid hormone on rennin secretion in vitro: a study using isolated rat kidney, isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells. Clin Sci (Lond) 84: 11-19, 1993.
35. Saussine C, Massfelder T, Parnin F, Judes C, Simeoni U, Helwig JJ. Renin stimulating properties of parathyroid hormone-related peptide in the isolated perfused rat kidney. Kidney Int 44: 764-773, 1993.
36. Skinner SL, McCubbin JW, Page IH. Renal baroreceptor control of acute renin release in normotensive, nephrogenic and neurogenic hypertensive dogs. Circ Res 15: 522-531, 1964.
37. Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y. Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats. Int J Cancer 128: 2215-2223, 2011.
38. Takahashi S, Hakuta M, Aiba K, Ito Y, Horikoshi N, Miura M, Hatake K, Ogata E. Elevation of circulating plasma cytokines in cancer patients with high plasma parathyroid hormone-related protein levels. Endocr Relat Cancer 10: 403-407, 2003.
39. Traynor TR, Smart A, Briggs JP, Schnermann J. Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cycloxygenase-2. Am J Physiol Renal Physiol 277: F706-F710, 1999.
40. Valvo E, Bedogna V, Gammaro L, Casagrande P, Ortalda V, Maschio G. Systemic hemodynamic pattern in primary hyperparathyroidism and its changes after parathyroidectomy. Miner Electrolyte Metab 17: 147-152, 1991.
41. Vander AJ, Miller R. Control of renin secretion in the anesthetized dog. Am J Physiol 207: 537-546, 1964.
42. Walls J, Ratcliffe WA, Howell A, Bundred NJ. Response to intravenous bisphosphonate therapy in hypercalcaemic patients with and without bone metastases: the role of parathyroid hormone-related protein. Br J Cancer 70: 169-172, 1994.
43. Winer N, Chokshi DS, Walkenhorst WG. Effects of cyclic AMP, sympathomimetic amines, and adrenergic receptor antagonists on rennin secretion. Circ Res 29: 239-248, 1971.
44. Wolzt M, Schmetterer L, Dorner G, Zelger G, Entlicher J, Kapiotis S, Eichler HG. Hemodynamic effects of parathyroid hormone-related peptide-(1-34) in humans. J Clin Endocrinol Metab 82: 2548-2551, 1997.
45. Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension 54: 1240-1247, 2009.
46. Yang T, Hassan S, Huang YG, Smart AM, Briggs JP, Schnermann JB. Expression of PTHrP, PTH/PTHrP receptor, and Ca(2)-sensing receptor mRNAs along the rat nephron. Am J Physiol Renal Physiol 272: F751-F758, 1997.
47. Yates AJ, Gutierrez GE, Smolens P, Travis PS, Katz MS, Aufdemorte TB, Boyce BF, Hymer TK, Poser JW, Mundy GR. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J Clin Invest 81: 932-938, 1988.