Electronegative LDLs from familial hypercholesterolemic patients are physicochemically heterogeneous but uniformly proapoptotic

Journal of Lipid Research

Volumn 48, Issue 1, 2007, Pages 177-184

  Chen, Hsin Hung ^a   Hosken, Brian D ^a   Huang, Max ^a   Gaubatz, John W ^a   Myers, Christine L ^b   Macfarlane, Ronald D ^b   Pownall, Henry J ^a   Yang, Chao Yuh ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Apoptosis; Atherosclerosis; Low density lipoprotein; Low density lipoprotein dense subfractions

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ADULT; APOPTOSIS; ARTICLE; CASE REPORT; CELL DENSITY; DENSITY GRADIENT CENTRIFUGATION; EPITHELIUM CELL; FEMALE; FRACTIONATION; HOMOZYGOSITY; HUMAN; HYPERCHOLESTEROLEMIA; MALE; PRIORITY JOURNAL;

APOPTOSIS; CENTRIFUGATION; ELECTROCHEMISTRY; ELECTROPHORESIS, AGAR GEL; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; KINETICS; LIPOPROTEINS, LDL; REFERENCE VALUES;

EID: 33845972963     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M500481-JLR200     Document Type: Article

References (39)

1. Mackey, R. H., L. H. Kuller, K. Sutton-Tyrrell, R. W. Evans, R. Holubkov, and K. A. Matthews. 2002. Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the Healthy Women Study. Am. J. Cardiol. 90: 71i-76i.
2. Koba, S., T. Hirano, T. Kondo, M. Shibata, H. Suzuki, M. Murakami, E. Geshi, and T. Katagiri. 2002. Significance of small dense low-density lipoproteins and other risk factors in patients with various types of coronary heart disease. Am. Heart J. 144: 1026-1035.
3. Bittner, V. 2002. Lipoprotein abnormalities related to women's health. Am. J. Cardiol. 90: 77i-84i.
4. de Graaf, J., H. L. Hak-Lemmers, M. P. Hectors, P. N. Demacker, J. C. Hendriks, and A. F. Stalenhoef. 1991. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler. Thromb. 11: 298-306.
5. Dejager, S., E. Bruckert, and M. J. Chapman. 1993. Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia. J. Lipid Res. 34: 295-308.
6. Bjornheden, T., A. Babyi, G. Bondjers, and O. Wiklund. 1996. Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system. Atherosclerosis. 123: 43-56.
7. Campos, H., G. O. Roederer, S. Lussier-Cacan, J. Davignon, and R. M. Krauss. 1995. Predominance of large LDL and reduced HDL2 cholesterol in NL men with coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 15: 1043-1048.
8. Campos, H., J. Lopez-Miranda, C. Rodriguez, M. Albajar, E. J. Schaefer, and J. M. Ordovas. 1997. Urbanization elicits a more atherogenic lipoprotein profile in carriers of the apolipoprotein A-IV-2 allele than in A-IV-1 homozygotes. Arterioscler. Thromb. Vasc. Biol. 17: 1074-1081.
9. Gray, R. S., D. C. Robbins, W. Wang, J. L. Yeh, R. R. Fabsitz, L. D. Cowan, T. K. Welty, E. T. Lee, R. M. Krauss, and B. V. Howard. 1997. Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians. The Strong Heart Study. Arterioscler. Thromb. Vasc. Biol. 17: 2713-2720.
10. Mykkanen, L., J. Kuusisto, S. M. Haffner, M. Laakso, and M. A. Austin. 1999. LDL size and risk of coronary heart disease in elderly men and women. Arterioscler. Thromb. Vasc. Biol. 19: 2742-2748.
11. Otvos, J. D., E. J. Jeyarajah, and W. C. Cromwell. 2002. Measurement issues related to lipoprotein heterogeneity. Am. J. Cardiol. 90: 22i-29i.
12. Blake, G. J., J. D. Otvos, N. Rifai, and P. M. Ridker. 2002. Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women. Circulation. 106: 1930-1937.
13. Avogaro, P., G. B. Bon, and G. Cazzolato. 1988. Presence of a modified low density lipoprotein in humans. Arteriosclerosis. 8: 79-87.
14. Cazzolato, G., P. Avogaro, and G. Bittolo-Bon. 1991. Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radic. Biol. Med. 11: 247-253.
15. Chen, C. H., T. Jiang, J. H. Yang, W. Jiang, J. Lu, G. K. Marathe, H. J. Pownall, C. M. Ballantyne, T. M. McIntyre, P. D. Henry, et al. 2003. Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation. 107: 2102-2108.
16. Sanchez-Quesada, J. L., M. Camacho, R. Anton, S. Benitez, L. Vila, and J. Ordonez-Llanos. 2003. Electronegative LDL of FH subjects: chemical characterization and induction of chemokine release from human endothelial cells. Atherosclerosis. 166: 261-270.
17. Yang, C. Y., J. L. Raya, H. H. Chen, C. H. Chen, Y. Abe, H. J. Pownall, A. A. Taylor, and C. V. Smith. 2003. Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arterioscler. Thromb. Vasc. Biol. 23: 1083-1090.
18. Moro, E., C. Zambon, S. Pianetti, G. Cazzolato, M. Pais, and G. Bittolo Bon. 1998. Electronegative low density lipoprotein subform (LDL-) is increased in type 2 (non-insulin-dependent) microalbuminuric diabetic patients and is closely associated with LDL susceptibility to oxidation. Acta Diabetol. 35: 161-164.
19. Lund-Katz, S., P. M. Laplaud, M. C. Phillips, and M. J. Chapman. 1998. Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction. Biochemistry. 37: 12867-12874.
20. Sevanian, A., J. Hwang, H. Hodis, G. Cazzolato, P. Avogaro, and G. Bittolo-Bon. 1996. Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations. Arterioscler. Thromb. Vasc. Biol. 16: 784-793.
21. Sanchez-Quesada, J. L., S. Benitez, C. Otal, M. Franco, F. Blanco-Vaca, and J. Ordonez-Llanos. 2002. Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects. J. Lipid Res. 43: 699-705.
22. Hosken, B. D., S. L. Cockrill, and R. D. Macfarlane. 2005. Metal ion complexes of EDTA: a solute system for density gradient ultracentrifugation analysis of lipoproteins. Anal. Chem. 77: 200-207.
23. Yang, C. Y., Z. W. Gu, H. X. Yang, M. Yang, A. M. Gotto, Jr., and C. V. Smith. 1997. Oxidative modifications of apoB-100 by exposure of low density lipoproteins to HOCL in vitro. Free Radic. Biol. Med. 23: 82-89.
24. Chancharme, L., P. Therond, F. Nigon, S. Lepage, M. Couturier, and M. J. Chapman. 1999. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. Arterioscler. Thromb. Vasc. Biol. 19: 810-820.
25. Tai, M., S. Kuo, H. Liang, K. Chiou, H. Lam, C. Hsu, H. J. Pownall, H. Chen, M. Huang, and C. Yang. 2006. Modulation of angiogenic processes in cultured endothelial cells by low density lipoproteins subfractions from patients with familial hypercholesterolemia. Atherosclerosis. 186: 448-457.
26. Sherman, M. B., E. V. Orlova, G. L. Decker, W. Chiu, and H. J. Pownall. 2003. Structure of triglyceride- rich human low-density lipoproteins according to cryoelectron microscopy. Biochemistry. 42: 14988-14993.
27. Lada, A. T., and L. L. Rudel. 2004. Associations of low density lipoprotein particle composition with atherogenicity. Curr. Opin. Lipidol. 15: 19-24.
28. Cho, H. K., G. Shin, S. K. Ryu, Y. Jang, S. P. Day, G. Stewart, C. J. Packard, J. Shepherd, and M. J. Caslake. 2002. Regulation of small and dense LDL concentration in Korean and Scottish men and women. Atherosclerosis. 164: 187-193.
29. Boullier, A., D. A. Bird, M. K. Chang, E. A. Dennis, P. Friedman, K. Gillotre-Taylor, S. Horkko, W. Palinski, O. Quehenberger, P. Shaw, et al. 2001. Scavenger receptors, oxidized LDL, and atherosclerosis. Ann. N. Y. Acad. Sci. 947: 214-222.
30. Steinberg, D. 1997. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272: 20963-20966.
31. Liao, F., J. A. Berliner, M. Mehrabian, M. Navab, L. L. Demer, A. J. Lusis, and A. M. Fogelman. 1991. Minimally modified low density lipoprotein is biologically active in vivo in mice. J. Clin. Invest. 87: 2253-2257.
32. Demuth, K., I. Myara, B. Chappey, B. Vedie, M. A. Pech-Amsellem, M. E. Haberland, and N. Moatti. 1996. A cytotoxic electronegative LDL subfraction is present in human plasma. Arterioscler. Thromb. Vasc. Biol. 16: 773-783.
33. Nissen, S. E., E. M. Tuzcu, P. Schoenhagen, T. Crowe, W. J. Sasiela, J. Tsai, J. Orazem, R. D. Magorien, C. O'Shaughnessy, and P. Ganz. 2005. Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) investigators. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352: 29-38.
34. Benitez, S., J. Ordonez-Llanos, M. Franco, C. Marin, E. Paz, J. Lopez-Miranda, C. Otal, F. Perez-Jimenez, and J. L. Sanchez-Quesada. 2004. Effect of simvastatin in familial hypercholesterolemia on the affinity of electronegative low-density lipoprotein subfractions to the low-density lipoprotein receptor. Am. J. Cardiol. 93: 414-420.
35. Davidson, W. S., D. L. Sparks, S. Lund-Katz, and M. C. Phillips. 1994. The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. J. Biol. Chem. 269: 8959-8965.
36. Sanchez-Quesada, J. L., S. Benitez, A. Perez, A. M. Wagner, M. Rigla, G. Carreras, L. Vila, M. Camacho, R. Arcelus, and J. Ordonez-Llanos. 2005. The inflammatory properties of electronegative low-density lipoprotein from type 1 diabetic patients are related to increased platelet-activating factor acetylhydrolase activity. Diabetologia. 48: 2162-2169.
37. Parasassi, T., G. Bittolo-Bon, R. Brunelli, G. Cazzolato, E. K. Krasnowska, G. Mei, A. Sevanian, and F. Ursini. 2001. Loss of apoB-100 secondary structure and conformation in hydroperoxide rich, electronegative LDL(-). Free Radic. Biol. Med. 31: 82-89.
38. Aviram, M., S. Lund-Katz, M. C. Phillips, and A. Chait. 1988. The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells. J. Biol. Chem. 263: 16842-16848.
39. McKeone, B. J., J. R. Patsch, and H. J. Pownall. 1993. Plasma triglycerides determine low density lipoprotein composition, physical properties, and cell-specific binding in cultured cells. J. Clin. Invest. 91: 1926-1933.