Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: A randomized trial

Contraception

Volumn 86, Issue 3, 2012, Pages 238-243

  Hovanessian Larsen, Linda ^a   Taylor, Deshawn ^a   Hawes, Debra ^a   Spicer, Darcy V ^a   Press, Michael F ^a   Wu, Anna H ^a   Pike, Malcolm C ^a,b   Pearce, C Leigh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Breast epithelial cells; Combined oral contraceptives; Estrogen receptor; Progesterone receptor; Progestin dose; Proliferation markers

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS NORETHISTERONE ACETATE; GESTAGEN; KI 67 ANTIGEN; MEDROXYPROGESTERONE ACETATE; MESTRANOL PLUS NORETHISTERONE; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; BREAST BIOPSY; BREAST DUCT; BREAST EPITHELIUM; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; HORMONAL THERAPY; HUMAN; HUMAN TISSUE; MENOPAUSE; ORAL CONTRACEPTION; RANDOMIZED CONTROLLED TRIAL;

ADULT; BIOPSY, LARGE-CORE NEEDLE; CELL PROLIFERATION; CONTRACEPTIVES, ORAL, COMBINED; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN RECEPTOR ALPHA; ETHINYL ESTRADIOL; FEMALE; HUMANS; IMAGE-GUIDED BIOPSY; IMMUNOHISTOCHEMISTRY; MAMMARY GLANDS, HUMAN; NORETHINDRONE; RECEPTORS, PROGESTERONE; UBIQUITIN-PROTEIN LIGASES;

EID: 84865106311     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2011.12.015     Document Type: Article

References (33)

1. L.J. Hofseth, A.M. Raafat, and J.R. Osuch Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast J Clin Endocrinol Metab 84 1999 4559 4565
2. S.A. Lee, R.K. Ross, and M.C. Pike An overview of menopausal oestrogen-progestin hormone therapy and breast cancer risk Br J Cancer 92 2005 2049 2058
3. R.L. Prentice, J.E. Manson, and R.D. Langer Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause Am J Epidemiol 170 2009 12 23
4. Collaborative Group on Hormonal Factors in Breast Cancer Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies Lancet 347 1996 1713 1727
5. P.A. Marchbanks, J.A. McDonald, and H.G. Wilson Oral contraceptives and the risk of breast cancer N Engl J Med 346 2002 2025 2032
6. L. Rosenberg, Y. Zhang, P.F. Coogan, B.L. Strom, and J.R. Palmer A case-control study of oral contraceptive use and incident breast cancer Am J Epidemiol 169 2009 473 479
7. M. Kumle, E. Weiderpass, T. Braaten, I. Persson, H.O. Adami, and E. Lund Use of oral contraceptives and breast cancer risk: the Norwegian-Swedish Women's Lifestyle and Health Cohort Study Cancer Epidemiol Biomarkers Prev 11 2002 1375 1381
8. M.D. Althuis, D.R. Brogan, and R.J. Coates Hormonal content and potency of oral contraceptives and breast cancer among young women Br J Cancer 88 2003 50 57
9. D.J. Hunter, G.A. Colditz, and S.E. Hankinson Oral contraceptive use and breast cancer: a prospective study of young women Cancer Epidemiol Biomarkers Prev 19 2010 2496 2502
10. F.Z. Stanczyk All progestins are not created equal Steroids 68 2003 879 890
11. Medical Letter Drug interactions with grapefruit juice Obstet Gynecol 105 2005 429 431
12. World Health Organization Department of Reproductive Health and Research Medical eligibility criteria for contraceptive use 3rd edition 2004 World Health Organization Geneva
13. C.R. Taylor, S.R. Shi, C. Chen, L. Young, C. Yang, and R.J. Cote Comparative study of antigen retrieval heating methods: microwave, microwave and pressure cooker, autoclave, and steamer Biotech Histochem 71 1996 263 270
14. S.R. Kumar, J. Singh, and G. Xia Receptor tyrosine kinase EphB4 is a survival factor in breast cancer Am J Pathol 169 2006 279 293
15. T.J. Anderson, S. Battersby, R.J.B. King, K. McPherson, and J.J. Going Oral contraceptive use influences resting breast proliferation Hum Pathol 20 1989 1139 1144
16. G. Williams, E. Anderson, and A. Howell Oral contraceptive (OCP) use increases proliferation and decreases oestrogen receptor content of epithelial cells in the normal human breast Int J Cancer 48 1991 206 210
17. J.R. Masters, J.O. Drife, and J.J. Scarisbrick Cyclic variation of DNA synthesis in human breast epithelium J Natl Cancer Inst 58 1977 1263 1265
18. J.S. Meyer Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine Hum Pathol 8 1977 67 81
19. T.J. Anderson, D.J. Ferguson, and G.M. Raab Cell turnover in the "resting" human breast: influence of parity, contraceptive pill, age and literality Br J Cancer 46 1982 376 382
20. T.A. Longacre, and S.A. Bartow A correlative morphologic study of human breast and endometrium in the menstrual cycle Am J Surg Pathol 10 1986 382 393
21. A.C. Nazário, G.R. De Lima, M.J. Simões, and N.F. Novo Cell kinetics of the human mammary lobule during the proliferative and secretory phase of the menstrual cycle Bull Assoc Anat 79 1995 23 27
22. H. Olsson, H. Jernström, and P. Alm Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors Breast Cancer Res Treat 40 1996 187 196
23. G. Söderqvist, E. Isaksson, B. von Schoultz, K. Carlström, E. Tani, and L. Skoog Proliferation of breast epithelial cells in healthy women during the menstrual cycle Am J Obstet Gynecol 176 1997 123 128
24. E. Isaksson, E. von Schoultz, and V. Odlind Effects of oral contraceptives on breast epithelial proliferation Breast Cancer Res Treat 65 2001 163 169
25. F. Feuerhake, W. Sigg, E.A. Höfter, P. Unterberger, and U. Welsch Cell proliferation, apoptosis, and expression of Bcl-2 and Bax in non-lactating human breast epithelium in relation to the menstrual cycle and reproductive history Breast Cancer Res Treat 77 2003 37 48
26. M.A. Navarrete, C.M. Maier, and R. Falzoni Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle Breast Cancer Res 7 2005 R306 R313
27. D. Garcia y Narvaiza, M.A. Navarrete, R. Falzoni, C.M. Maier, and A.C. Nazário Effect of combined oral contraceptives on breast epithelial proliferation in young women Breast J 14 2008 450 455
28. J.D. Jacquemier, J. Hassoun, M. Torrente, and P.M. Martin Distribution of estrogen and progesterone receptors in healthy tissue adjacent to breast lesions at various stages - Immunohistochemical study of 107 cases Breast Cancer Res Treat 15 1990 109 117
29. D. Ricketts, L. Turnbull, and G. Ryall Estrogen and progesterone receptors in the normal female breast Cancer Res 51 1991 1817 1822
30. S. Battersby, B.J. Robertson, T.J. Anderson, R.J. King, and K. McPherson Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast Br J Cancer 65 1992 601 607
31. G. Söderqvist, B. von Schoultz, E. Tani, and L. Skoog Estrogen and progesterone receptor content in breast epithelial cells from healthy women during the menstrual cycle Am J Obstet Gynecol 168 1993 874 879
32. E. Isaksson, L. Sahlin, and G. Söderqvist Expression of sex steroid receptors and IGF-1 mRNA in breast tissue - effects of hormonal treatment J Steroid Biochem Mol Biol 70 1999 257 262
33. G. Hallberg, I. Persson, T. Naessén, and C. Magnusson Effects of pre- and postmenopausal use of exogenous hormones on receptor content in normal human breast tissue: a randomized study Gynecol Endocrinol 24 2008 475 480