Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer

In Vivo

Volumn 26, Issue 4, 2012, Pages 565-570

  Menen, Rhiana S ^a,b,c   Hassanein, Mohamed K ^a,b   Momiyama, Masashi ^a,b,d   Suetsugu, Atsushi ^a,b,e   Moossa, Abdool R ^b   Hoffman, Robert M ^a,b   Bouvet, Michael ^b  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

^e GIFU UNIVERSITY   (Japan)

Author keywords

Fluorescence imaging; Green fluorescent protein; Macrophages; Orthotopic mouse models; Pancreatic cancer; Red fluorescent protein; Tumor microenvironment

Indexed keywords

RED FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CONTROLLED STUDY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PANCREAS CANCER; PERITONEUM METASTASIS; PRIMARY TUMOR; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TUMOR CELL; TUMOR GROWTH;

EID: 84865078467     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hoffman RM: Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 17: 343-359, 1999.
2. Bingle L, Lewis CE, Corke KP, Reed MW and Brown NJ: Macrophages promote angiogenesis in human breast tumour spheroids in vivo . Br J Cancer 94: 101-107, 2006. (Pubitemid 43088548)
3. Condeelis J and Pollard JW: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124: 263-266, 2006. (Pubitemid 43121975)
4. Balkwill F, Charles KA and Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7: 211-217, 2005. (Pubitemid 40568680)
5. Chen Q, Zhang XH and Massague J: Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20: 538-549, 2011.
6. Lin EY, Nguyen AV, Russell RG and Pollard JW: Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193: 727-740, 2001.
7. Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759, 2005. (Pubitemid 41400849)
8. Hoffman RM: The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer 5: 796-806, 2005.
9. Hoffman RM and Yang M: Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc 1: 928-935, 2006.
10. Yang M, Reynoso J, Jiang P, Li L, Moossa AR and Hoffman RM: Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res 64: 8651-8656, 2004. (Pubitemid 39552079)
11. Bouvet M, Wang J, Nardin SR, Nassirpour R, Yang M, Baranov E, Jiang P, Moossa AR and Hoffman RM: Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res 62: 1534-1540, 2002. (Pubitemid 34407819)
12. Fu X, Guadagni F and Hoffman RM: A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc Natl Acad Sci USA 89: 5645-5649, 1992.
13. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM and Bouvet M: A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res 113: 151-160, 2003. (Pubitemid 36999806)
14. Chen JJ, Lin YC, Yao PL, Yuan A, Chen HY, Shun CT, Tsai MF, Chen CH and Yang PC: Tumor-associated macrophages: the double-edged sword in cancer progression. J Clin Oncol 23: 953-964, 2005. (Pubitemid 46202315)
15. Ryder M, Ghossein RA, Ricarte-Filho JC, Knauf JA and Fagin JA: Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endocr Relat Cancer 15: 1069-1074, 2008.
16. Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG and Rose DW: Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 124: 615-629, 2006. (Pubitemid 43199445)