Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Kim, Hye Eun ^a   Kim, Dae Ghon ^b   Lee, Kyung Jin ^a   Son, Jang Geun ^a   Song, Min Young ^a   Park, Young Mi ^a   Kim, Jae Jung ^a   Cho, Sung Won ^c   Chi, Sung Gil ^d   Cheong, Hyun Sub ^e   Shin, Hyoung Doo ^e,f   Lee, Sang Wook ^a   Lee, Jong Keuk ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

^c Ajou University School of Medicine   (South Korea)

^d Korea University   (South Korea)

^e SNP Genetics Inc   (South Korea)

^f Sogang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GEMININ; MESSENGER RNA;

ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; CENTROMERE PROTEIN F GENE; COLORECTAL CANCER; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE 13 GENE; FAMILY WITH SEQUENCE SIMILARITY 82 MEMBER B GENE; GEMININ GENE; GENE; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; PRIMARY TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR GENE; TUMOR VOLUME;

AGE OF ONSET; ANIMALS; CARCINOMA, HEPATOCELLULAR; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; COLORECTAL NEOPLASMS; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MICE; MICROFILAMENT PROTEINS; NIH 3T3 CELLS; ONCOGENES; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84865056937     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043223     Document Type: Article

References (29)

1. Albertson DG, Collins C, McCormick F, Gray JW, ((2003)) Chromosomal aberrations in solid tumors. Nature Genet 34:: 369--376.
2. Stratton MR, Campbell PJ, Futreal PA, ((2009)) The cancer genome. Nature 458:: 719--724.
3. Medina PP, Castillo SD, Blanco S, Sanz-Garcia M, Largo C, et al. ((2009)) The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer. Hum Mol Genet 18:: 1343--1352.
4. Liu W, Chang B, Sauvageot J, Dimitrov L, Gielzak M, et al. ((2006)) Comprehensive assessment of DNA copy number alterations in human prostate cancers using Affymetrix 100K SNP mapping array. Genes Chromosomes Cancer 45:: 1018--1032.
5. Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS, ((2010)) A census of amplified and overexpressed human cancer genes. Nature Rev Cancer 10:: 59--64.
6. Albertson DG, ((2006)) Gene amplification in cancer. Trends Genet 22:: 447--455.
7. Thorgeirsson SS, Grisham JW, ((2002)) Molecular pathogenesis of human hepatocellular carcinoma. Nature Genet 31:: 339--346.
8. Feitelson MA, Sun B, Satiroglu Tufan NL, Liu J, Pan J, et al. ((2002)) Genetic mechanisms of hepatocarcinogenesis. Oncogene 21:: 2593--2604.
9. Chen CF, Hsu EC, Lin KT, Tu PH, Chang HW, et al. ((2010)) Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma. Hepatology 52:: 1690--1701.
10. Peiffer DA, Le JM, Steemers FJ, Chang W, Jenniges T, et al. ((2006)) High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping. Genome Res 16:: 1136--1148.
11. Bae JS, Cheong HS, Kim JO, Lee SO, Kim EM, et al. ((2008)) Identification of SNP markers for common CNV regions and association analysis of risk of subarachnoid aneurysmal hemorrhage in Japanese population. Biochem Biophys Res Commun 373:: 593--596.
12. LaFramboise T, ((2009)) Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances. Nucleic Acids Res 37:: 4181--4193.
13. O'Brien SL, Fagan A, Fox EJ, Millikan RC, Culhane AC, et al. ((2007)) CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer. Int J Cancer 120:: 1434--1443.
14. Montanari M, Boninsegna A, Faraglia B, Coco C, Giordano A, et al. ((2005)) Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors. J Cell Physiol 202:: 215--222.
15. Gardner L, Malik R, Shimizu Y, Mullins N, Elshamy WM, ((2011)) Geminin overexpression prevents the complete of topoisomerase IIα chromosome decatenation, leading to aneruploidy in human mammary epithelial cells. Breast Cancer Res 13:: R53.
16. Even Y, Durieux S, Escande ML, Lozano JC, Peaucellier G, et al. ((2006)) CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. J Cell Biochem 99:: 890--904.
17. Oishi K, Okano H, Sawa H, ((2007)) RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J Cell Biol 179:: 1149--1162.
18. Zhu W, Chen Y, Dutta A, ((2004)) Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. Mol Cell Biol 24:: 7140--7150.
19. Green BM, Finn KJ, Li JJ, ((2010)) Loss of DNA replication control is a potent inducer of gene amplification. Science 329:: 943--946.
20. Zhu W, DePamphilis ML, ((2009)) Selective killing of cancer cells by suppression of Geminin activity. Cancer Res 69:: 4870--4877.
21. Huang WC, Taylor S, Nguyen TB, Tomaszewski JE, Libertino JA, et al. ((2002)) KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. DNA Cell Biol 21:: 707--715.
22. Paterlini-Bréchot P, Saigo K, Murakami Y, Chami M, Gozuacik D, et al. ((2003)) Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 22:: 3911--3916.
23. Park JG, Lee JH, Kang MS, Park KJ, Jeon YM, et al. ((1995)) Characterization of cell lines established from human hepatocellular carcinoma. Int J Cancer 62:: 276--282.
24. Lee JH, Kang MS, Ku JL, Park YJ, Lee KU, et al. ((1999)) Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA. World J Gastroenterol 5:: 289--295.
25. Ku JL, Park JG, ((2005)) Biology of SNU cell lines. Cancer Res Treat 37:: 1--19.
26. Evans DM, Barrett JC, Cardon LR, ((2008)) To what extent do scans of non-synonymous SNPs complement denser genome-wide association studies? Eur J Hum Genet 16:: 718--723.
27. Nickerson DA, Tobe VO, Taylor SL, ((1997)) PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res 25:: 2745--2751.
28. Livak KJ, Schmittgen TD, ((2001)) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:: 402--408.
29. Lee KJ, Kim JY, Choi JH, Kim HG, Chung YC, et al. ((2006)) Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum. Food Chem Toxicol 44:: 1890--1896.