Effects of high glucose on vascular endothelial growth factor synthesis and secretion in aortic vascular smooth muscle cells from obese and lean zucker rats

International Journal of Molecular Sciences

Volumn 13, Issue 8, 2012, Pages 9478-9488

  Doronzo, Gabriella ^a   Viretto, Michela ^a   Russo, Isabella ^a   Mattiello, Luigi ^a   Anfossi, Giovanni ^a   Trovati, Mariella ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Diabetes; Glucose; Insulin resistance; Lean Zucker rats; Obese zucker rats; Osmotic stress; Vascular endothelial growth factor; Vascular smooth muscle cells

Indexed keywords

GLUCOSE; LEVO GLUCOSE; MANNITOL; VASCULOTROPIN; ANTIDIABETIC AGENT; INSULIN; SWEETENING AGENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANIMAL CELL; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; NONHUMAN; OBESITY; OSMOSIS; OSMOTIC STRESS; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECTS; HYPERGLYCEMIA; MALE; METABOLISM; OSMOTIC PRESSURE; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION (PROCESS); ZUCKER RAT;

ANIMALS; AORTA; GLUCOSE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SMOOTH, VASCULAR; OBESITY; OSMOTIC PRESSURE; RATS; RATS, ZUCKER; SWEETENING AGENTS; THINNESS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84865040764     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13089478     Document Type: Article

References (23)

1. Wirostko, B.; Wong, T.Y.; Simò, R. Vascular endothelial growth factor and diabetic complications. Progr. Retin. Eye Res. 2008, 27, 608-621.
2. Ferrara, N.; Davis-Smith, T. The biology of vascular endothelial growth factor. Endocr. Rev. 1997, 18, 4-25.
3. Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 2000, 6, 389-395. 4.
4. Risau, W. Mechanisms of angiogenesis. Nature 1997, 386, 671-674.
5. Heil, M.; Schaper, W. Pathophysiology of collateral development. Coron. Artery. Dis. 2004, 15, 373-378.
6. Doronzo, G.; Russo, I.; Mattiello, L.; Anfossi, G.; Bosia, A.; Trovati, M. Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and insulin resistance. Eur. J. Clin. Investig. 2004, 34, 664-673.
7. Doronzo, G.; Russo, I.; Mattiello, L.; Riganti, C.; Anfossi, G.; Trovati, M. Insulin activates hypoxia-inducible factor-1α in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signaling. Diabetologia 2006, 49, 1049-1063.
8. Chou, E.; Suzuma, I.; Way, K.J.; Opland, D.; Clermont, A.C.; Naruse, K.; Suzuma, K.; Bowling, N.L.; Vlahos, C.J.; Aiello L.P.; et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue. Circulation 2002, 105, 373-379.
9. Scott-Burden, T.; Resnik, T.J.; Hahn, A.W.A.; Baur, U.; Box, R.J.; Buhler, F.R. Induction of growth-related metabolism in human vascular muscle cells by low density lipoprotein. J. Biol. Chem. 1989, 264, 12582-12589.
10. Waltenberger, J. Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications. Cardiovasc. Res. 2001, 49, 554-560.
11. Abaci, A.; Oguzhan, A.; Kahraman, S.; Eryol, N.K.; Unal, S.; Arinc, H.; Ergin, A. Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation 1999, 99, 2239-2242.
12. Giugliano, D.; Acampora, R.; D'Onofrio, F. Medical hypothesis: cardiovascular complications of diabetes mellitus-from glucose to insulin and back. Diabetes Metab. 1994, 20, 445-453.
13. Hoshi, S.; Nomoto, K.; Kuromitsu, J.; Tomari, S.; Nagata M. High glucose induced VEGF expression via PKC and ERK in glomerular podocytes. Biochem. Biophys. Res. Comm. 2002, 290, 177-184.
14. Whiteside, C.; Wang, H.; Xia, L.; Munk, S.; Goldberg, H.J.; Fantus, G. Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells. Exp. Diabetes Res. 2009, 2009, 1-11.
15. Xia, L.; Wang, H.; Munk, S.; Frecker, H.; Goldberg, H.; Fantus, I.G.; Whiteside, C.I. Reactive oxygen species, PKC-β1 and PKC-ξ mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells. Am. J. Physiol. Endocrinol. Metabol. 2007, 293,E1280-E1288.
16. Sun, J.; Sun S.; Sun, Y.; Wang, X. Intermittent high glucose enhances cell proliferation and VEGF expression in retinal endothelial cells: The role of mithocondrial reactive oxygen species. Mol. Cell. Biochem. 2010, 343, 27-35.
17. Wu, E.; Xia, X.; Jiang, C.; Wu, J.; Zhang, S.; Zheng, Z.; Liu, W.; Zhang, Y.; Ren, H.; Wei C.; et al. High glucose attenuates insulin-induced VEGF expression in bovine retinal microvascularendothelial cells. Eye 2010, 24, 145-151.
18. Natarajan, R.; Bai, W.; Lanting, L.; Gonzales, N.; Nadler, J. Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. Am. J. Physiol. Heart. Circ. Physiol. 1997, 273, H2224-H2231.
19. Dulak, J.; Tomala, K.; Loboda, A.; Jozkowicz, A. Nitric oxide-dependent synthesis of vascular endothelial growth factor is impaired by high glucose. Life Sci. 2004, 75, 2573-2586.
20. Chiu, C.J.; Taylor, A. Dietary hyperglycaemia, glycemic index and metabolic retinal disease. Progr. Retin. Eye Res. 2011, 30, 18-53.
21. Schrijvers, B.F.; Flyvbjerg, A.; de Vriese, A.S. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney. Int. 2004, 6, 2003-2017.
22. Virmani, R.; Burke, A.P.; Farb, A.; Kolodgie, F.D. Pathology of the vulnerable plaque. J. Am. Coll. Cardiol. 2006, 47, C13-C18.
23. Holm, P.W.; Slart, R.H.J.A.; Zeebregts, C.J.; Hillebrands, J.L.; Tio, R.A. Atherosclerotic plaque development and instability: A dual role for VEGF. Ann. Med. 2009, 41, 257-264.