Detection of differential levels of proteins in the urine of patients with endometrial cancer: Analysis using two-dimensional gel electrophoresis and O-glycan binding lectin

International Journal of Molecular Sciences

Volumn 13, Issue 8, 2012, Pages 9489-9501

  Mu, Alan Kang Wai ^a   Lim, Boon Kiong ^b   Hashim, Onn Haji ^b   Shuib, Adawiyah Suriza ^a,b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

2 dimensional gel electrophoresis; Biomarker; Champedak galactose binding lectin; Endometrial cancer; Proteomics; Urine

Indexed keywords

CD59 ANTIGEN; CHAMPEDAK GALACTOSE BINDING LECTIN; GLYCOPROTEIN; LECTIN; NEBULIN; O GLYCAN BINDING LECTIN; OROSOMUCOID; TUMOR MARKER; UNCLASSIFIED DRUG; ZINC ALPHA 2 GLYCOPROTEIN; PROTEOME;

ADULT; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; EARLY CANCER; ENDOMETRIUM CANCER; FEMALE; HUMAN; IMAGE ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN URINE LEVEL; TWO DIMENSIONAL ELECTROPHORESIS; VALIDATION STUDY; CASE CONTROL STUDY; COMPARATIVE STUDY; ENDOMETRIUM; ENDOMETRIUM TUMOR; GLYCOSYLATION; METABOLISM; PROCEDURES; PROTEOMICS; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; URINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CASE-CONTROL STUDIES; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; LECTINS; PROTEOME; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL;

EID: 84865040305     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13089489     Document Type: Article

References (41)

1. Attarha, S.; Mints, M.; Andersson, S.; Souchelnytskyi, S. Endometrial cancer and application of proteomics. Exp. Oncol. 2011, 33, 174-177.
2. Ueda, Y.; Enomoto, T.; Kimura, T.; Miyatake, T.; Yoshino, K.; Fujita, M.; Kimura, T. Serum biomarkers for early detection of gynecologic cancers. Cancers 2010, 2, 1312-1327.
3. Barratt, J.; Topham, P. Urine proteomics: The present and future of measuring urinary protein components in disease. CMAJ 2007, 177, 361-368.
4. Kreunin, P.; Zhao, J.; Rosser, C.; Urquidi, V.; Lubman, D.M.; Goodison, S. Bladder cancer associated glycoprotein signatures revealed by urinary proteomic profiling. J. Proteome Res. 2007, 6, 2631-2639.
5. Abdullah-Soheimi, S.S.; Lim, B.K.; Hashim, O.H.; Shuib, A.S. Patients with ovarian carcinoma excrete different altered levels of urine CD59, kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin. Proteome Sci. 2010, 8, 58.
6. Brockhausen, I. Mucin-type O-glycans in human colon and breast cancer: Glycodynamics and functions. EMBO Rep. 2006, 7, 599-604.
7. Abdul-Rahman, P.S.; Lim, B.K.; Hashim, O.H. Expression of high abundance proteins in sera of patients with endometrial and cervical cancers: Analysis using two-dimensional gel electrophoresis with silver staining and lectin detection methods. Electrophoresis 2007, 28, 1989-1996.
8. Mohamed, E.; Abdul-Rahman, P.S.; Doustjalali, S.R.; Chen, Y.; Lim, B.K.; Omar, S.Z.; Bustam, Z.; Singh, V. A.; Muhammad-Taib, N. A.; Yip, C.H.; et al. Lectin-based electrophoretic analysis of the expression of the 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies. Electrophoresis 2008, 29, 2645-2650.
9. Mukhopadhyay, P.; Chakraborty, S.; Ponnusamy, M.P.; Lakshmanan, I.; Jain, M.; Batra, S.K. Mucins in the pathogenesis of breast cancer: Implications in diagnosis, prognosis and therapy. Biochim. Biophys. Acta 2011, 1815, 224-240.
10. Hashim, O.H.; Gendeh, G.S.; Nik Jaafar, M.I. Comparative analyses of IgA1 binding lectins from seeds of six distinct clones of Artocarpus integer. Biochem. Mol. Biol. Int. 1993, 29, 69-76.
11. Rahman, M.A.; Karsani, S.A.; Othman, I.; Abdul Rahman, P.S.; Hashim, O.H. Galactose binding lectin from the seeds of champedak (Artocarpus integer): Sequences of its subunits and interactions with human serum O-glycosylated glycoproteins. Biochem. Biophys. Res. Commun. 2002, 295, 1007-1013.
12. UniProt KB. Available online: http://www.uniprot.org (accessed on 22 February 2012).
13. Matrix Science; Matrix Science Inc.: Boston, MA, USA, 2012.
14. Julenius, K.; Mølgaard, A.R.; Gupta, R.; Brunak, S. Prediction, conservation analysis and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 2005, 15, 153-164.
15. Hassan, M.I.; Waheed, A.; Yadav, S.; Singh, T.P.; Ahmad, F. Zinc alpha 2-glycoprotein: A multidisciplinary protein. Mol. Cancer Res. 2008, 6, 892-906.
16. Hale, L.P.; Price, D.T.; Sanchez, L.M.; Demark-Wahnefried, W.; Madden, J.F. Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer. Clin. Cancer Res. 2001, 7, 846-853.
17. Hu, S.; Matha, A.; Boontheung, P.; Wang, J.; Zhou, H.; Jiang, J.; Elashoff, D.; Wei, R.; Loo, J.A.; Wong, D.T. Salivary proteomics for oral cancer biomarker discovery. Clin. Cancer Res. 2008, 4, 6246-6252.
18. Tantipaiboonwong, P.; Sinchaikul, S.; Sriyam, S.; Phutrukul, S.; Chen, S. Different techniques for urinary protein analysis of normal and lung cancer patients. Proteomics 2005, 5, 1140-1149.
19. Murray, K.P.; Mathure, S.; Kaul, R.; Khan, S.; Carson, L.F.; Twiggs, L.B.; Martens, M.G.; Kaul, A. Expression of complement regulatory proteins-CD 35, CD 46, CD 55, and CD 59-In benign and malignant endometrial tissue. Gynecol. Oncol. 2000, 76, 176-182.
20. Dubois, V.; Delort, L.; Mishellany, F.; Jarde, T.; Billard, H.; Lequeux, C.; Damour, O.; Penault-Llorca, F.; Vasson, M.P.; Caldefie-Chezet, F. Zinc-alpha2-glycoprotein: A new biomarker of breast cancer? Anticancer Res. 2010, 30, 2919-2925.
21. Huang, Y.; Li, L.Z.; Zhang, C.Z.Y.; Yi, C.; Liu, L.L.; Zhou, X.; Xie, G.B.; Cai, M.Y.; Li, Y.; Yun, J.P. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. J. Transl. Med. 2012, 10, 106.
22. Alexander, H.; Stegner, A.L.; Wagner-Mann, C.; Du Bois, G.C.; Alexander, S.; Sauter, E.R. Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid. Clin. Cancer Res. 2004, 10, 7500-7510.
23. Zhang, X.; Xiao, Z.; Liu, X.; Du, L.; Wang, L.; Wang, S.; Zheng, N.; Zheng, G.; Li, W.; Zhang, X.; et al. The potential role of ORM2 in the development of colorectal cancer. PLoS One 2012, 7, e31868.
24. Bachtiar, I.; Santoso, J.M.; Atmanegara, B.; Gani, R.A.; Hasan, I.; Lesmana, L.A.; Sulaiman, A.; Gu, J.; Tai, S. Combination of alpha-1-acid glycoprotein and alpha-fetoprotein as an improved diagnostic tool for hepatocellular carcinoma. Clin. Chim. Acta 2009, 399, 97-101.
25. Boylan, K.L.M.; Andersen, J.D.; Andersen, L.B.; Higgins, L.A.; Skubitz, A.P.N. Quantitative proteomic analysis by iTRAQ® for the identification of candidate biomarkers in ovarian cancer serum. Proteome Sci. 2010, 8, 31.
26. Wang, Y.S.; Cao, R.; Jin, H.; Huang, Y.P.; Zhang, X.Y.; Cong, Q.; He, Y.F.; Xu, C.J. Altered protein expression in serum from endometrial hyperplasia and carcinoma patients. J. Hematol. Oncol. 2011, 4, 15.
27. Park, J.Y.; Kim, S.A.; Chung, J.W.; Bang, S.; Park, S.W.; Paik, Y.K.; Song, S.Y. Proteomicanalysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. J. Cancer Res. Clin. Oncol. 2011, 137, 1229-1238.
28. Li, W.; Li, J.F.; Qu, Y.; Chen, X.H.; Qin, J.M.; Gu, Q.L.; Yan, M.; Zhu, Z.G.; Liu, B.Y. Comparative proteomics analysis of human gastric cancer. World J. Gastroenterol. 2008, 14, 5657-5664.
29. Tosner, J.; Krejsek, J.; Louda, B. Serum prealbumin, transferrin and alpha-1-acid glycoprotein in patients with gynecological carcinomas. Neoplasma 1988, 35, 403-411.
30. Weeks, M.E; Hariharan, D.; Petronijevic, L.; Radon, T.P.; Whiteman, H.J.; Kocher, H.M.; Timms, F; Lemoine, N.R; Crnogorac-Jurcevic, T. Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma. Proteomics Clin. Appl. 2008, 2, 1047-1057.
31. Pappas, C.T.; Bliss, K.T.; Zieseniss, A.; Gregorio, C.C. The nebulin family: An actin support group. Trends Cell Biol. 2011, 21, 29-37.
32. Madera, M.; Mechref, Y.; Klouckova, I.; Novotny, M.V. Semiautomated high-sensitivity profiling of human blood serum glycoproteins through lectin preconcentration and multidimensional chromatography/tandem mass spectrometry. J. Proteome Res. 2006, 5, 2348-2363.
33. Ottenheijm, C.A.C.; Granzier, H. Lifting the nebula: Novel insights into skeletal muscle contractility. Physiology 2010, 25, 304-310.
34. Tanaka, Y.; Akiyama, H.; Kuroda, T.; Jung, G.; Tanahashi, K.; Sugaya, H.; Utsumi, J.; Kawasaki, H.; Hirano, H. A novel approach and protocol for discovering extremely low-abundance proteins in serum. Proteomics 2006, 6, 4845-4855.
35. Shuib, A.S.; Chua, C.T.; Hashim, O.H. Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha heavy chains. Nephron 1998, 78, 290-295.
36. Hashim, O.H.; Shuib, A.S.; Chua, C.T. Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains. Nephron 2001, 89, 422-425.
37. Heukeshoven, J.; Dernick, R. Improved silver staining procedure for fast staining in PhastSystem Development Unit. I. Staining of sodium dodecyl sulfate gels. Electrophoresis 1988, 9, 28-32.
38. Shevchenko, A.; Wilm, M.; Vorm, O.; Mann, M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal. Chem. 1996, 68, 850-858.
39. Benjamini, Y.; Hochberg, Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. B 1995, 57, 289-300.
40. Luque-Garcia, J.L.; Neubert, T.A. On-membrane tryptic digestion of proteins for mass spectrometry analysis. Methods Mol. Biol. 2009, 536, 331-341.
41. Seriramalu, R.; Pang, W.W.; Jayapalan, J.J.; Mohamed, E.; Abdul-Rahman, P.S.; Bustam, A.Z.; Khoo, A.S.B.; Hashim, O.H. Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma. Electrophoresis 2010, 31, 2388-2395.