A tissue factor targeted nanomedical system for thrombi-specific drug delivery

Biomaterials

Volumn 33, Issue 30, 2012, Pages 7643-7654

  Shi, Wei ^a,b   Mei, Heng ^a,b   Deng, Jun ^a,b   Chen, Chen ^a,b   Wang, Huafang ^a,b   Guo, Tao ^a,b   Zhang, Bo ^a,b   Li, Le ^a,b   Pang, Zhiqing ^c   Jiang, Xinguo ^c   Shen, Shun ^c   Hu, Yu ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Cerebral infarction; Nanoparticles; Thrombi; Tissue factor

Indexed keywords

ATHEROSCLEROTIC PLAQUE; BLOOD CIRCULATION; CEREBRAL INFARCTION; ENDOCYTOSIS PATHWAY; FLUORESCENCE IMAGE; HIGH CONCENTRATION; IN-VITRO; IN-VIVO; MEMBRANE-BOUND; PHARMACOKINETIC STUDIES; THROMBI; TISSUE FACTORS; TUMOR VASCULATURE;

CARDIOVASCULAR SYSTEM; COAGULATION; CONFOCAL MICROSCOPY; DRUG DELIVERY; MOLECULAR BIOLOGY; NANOPARTICLES;

TISSUE;

EGF1 EGFP FUSION PROTEIN; FIBRINOGEN; HYBRID PROTEIN; POLY(D,L LACTIDE COGLYCOLIDE); POLYLACTIDE; POLYMER; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BRAIN CORTEX; BRAIN INFARCTION; CELL VIABILITY; CIRCULATION; CONFOCAL MICROSCOPY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; ENDOTHELIUM LESION; FIBRINOGEN BLOOD LEVEL; FLUORESCENCE IMAGING; GENE OVEREXPRESSION; GENETIC TRANSFECTION; INTERNATIONAL NORMALIZED RATIO; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTHROMBIN TIME; RAT; THROMBIN TIME; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ANIMALS; BLOOD COAGULATION; BRAIN; CELL DEATH; CELLS, CULTURED; COUMARINS; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; FACTOR VII; GREEN FLUORESCENT PROTEINS; INJECTIONS, INTRAVENOUS; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, FLUORESCENCE; STATIC ELECTRICITY; THIAZOLES; THROMBOPLASTIN; THROMBOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865037167     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.094     Document Type: Article

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