메뉴 건너뛰기




Volumn 41, Issue 3, 2012, Pages 1157-1163

Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells

Author keywords

Discriminating p53 mutants; Functional analysis of separated alleles in yeast; p53; Temperature dependent p53 mutants; Transactivation

Indexed keywords

AMIFOSTINE; PROTEIN P53;

EID: 84865025982     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1520     Document Type: Article
Times cited : (9)

References (31)
  • 1
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • DOI 10.1002/humu.20495
    • Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P and Olivier M: Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat 28: 622-629, 2007. (Pubitemid 46744292)
    • (2007) Human Mutation , vol.28 , Issue.6 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6    Olivier, M.7
  • 2
    • 0033809941 scopus 로고    scopus 로고
    • P53 from complexity to simplicity: Mutant p53 stabilization, gain-of-function, and dominant-negative effect
    • Blagosklonny MV: P53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect. FASEB J 14: 1901-1907, 2000.
    • (2000) FASEB J , vol.14 , pp. 1901-1907
    • Blagosklonny, M.V.1
  • 3
    • 0042692855 scopus 로고    scopus 로고
    • Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity
    • DOI 10.1073/pnas.1633803100
    • Resnick MA and Inga A: Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc Natl Acad Sci USA 100: 9934-9939, 2003. (Pubitemid 37087046)
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.17 , pp. 9934-9939
    • Resnick, M.A.1    Inga, A.2
  • 7
    • 34848901685 scopus 로고    scopus 로고
    • The p53 mutation 'gradient effect' and its clinical implications
    • Zambetti GP: The p53 mutation 'gradient effect' and its clinical implications. J Cell Physiol 213: 370-373, 2007.
    • (2007) J Cell Physiol , vol.213 , pp. 370-373
    • Zambetti, G.P.1
  • 9
    • 77955363995 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: Origins, consequences, and clinical use
    • Olivier M, Hollstein M and Hainaut P: TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb Perspect Biol 2: a001008, 2010.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Olivier, M.1    Hollstein, M.2    Hainaut, P.3
  • 10
    • 0036191959 scopus 로고    scopus 로고
    • V272M) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1
    • DOI 10.1002/mc.10038
    • North S, Pluquet O, Maurici D, El-Ghissassi F and Hainaut P: Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1. Mol Carcinog 33: 181-188, 2002. (Pubitemid 34195199)
    • (2002) Molecular Carcinogenesis , vol.33 , Issue.3 , pp. 181-188
    • North, S.1    Pluquet, O.2    Maurici, D.3    Ghissassi, F.E.4    Hainaut, P.5
  • 11
    • 0035859006 scopus 로고    scopus 로고
    • Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay
    • DOI 10.1038/sj.onc.1204428
    • Maurici D, Monti P, Campomenosi P, North S, Frebourg T, Fronza G and Hainaut P: Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene 20: 3533-3540, 2001. (Pubitemid 32619406)
    • (2001) Oncogene , vol.20 , Issue.27 , pp. 3533-3540
    • Maurici, D.1    Monti, P.2    Campomenosi, P.3    North, S.4    Frebourg, T.5    Fronza, G.6    Hainaut, P.7
  • 12
    • 0032516219 scopus 로고    scopus 로고
    • Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay
    • Di Como C and Prives C: Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in yeast-based assay. Oncogene 19: 2527-2539, 1998. (Pubitemid 28258584)
    • (1998) Oncogene , vol.16 , Issue.19 , pp. 2527-2539
    • Di, C.C.J.1    Prives, C.2
  • 13
    • 0034594995 scopus 로고    scopus 로고
    • Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: Definition of mutant states for rescue in cancer therapy
    • Bullock AN, Henckel J and Fersht AR: Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy. Oncogene 19: 1245-1256, 2000. (Pubitemid 30160617)
    • (2000) Oncogene , vol.19 , Issue.10 , pp. 1245-1256
    • Bullock, A.N.1    Henckel, J.2    Fersht, A.R.3
  • 15
    • 33847326819 scopus 로고    scopus 로고
    • Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
    • DOI 10.1093/carcin/bgl132
    • Dearth LR, Qian H, Wang T, Baroni TE, Zeng J, Chen SW, Yi SY and Brachmann RK: Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers. Carcinogenesis 28: 289-298, 2007. (Pubitemid 46321844)
    • (2007) Carcinogenesis , vol.28 , Issue.2 , pp. 289-298
    • Dearth, L.R.1    Qian, H.2    Wang, T.3    Baroni, T.E.4    Zeng, J.5    Chen, S.W.6    Yi, S.Y.7    Brachmann, R.K.8
  • 16
    • 34047224955 scopus 로고    scopus 로고
    • Structure-function-rescue: The diverse nature of common p53 cancer mutants
    • DOI 10.1038/sj.onc.1210291, PII 1210291
    • Joerger AC and Fersht AR: Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene 26: 2226-2242, 2007. (Pubitemid 46536643)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2226-2242
    • Joerger, A.C.1    Fersht, A.R.2
  • 17
    • 39749191326 scopus 로고    scopus 로고
    • Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast
    • DOI 10.1038/sj.onc.1210748, PII 1210748
    • Grochova D, Vankova J, Damborsky J, Ravcukova B, Smarda J, Vojtesek B and Smardova J: Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast. Oncogene 27: 1243-1252, 2008. (Pubitemid 351294697)
    • (2008) Oncogene , vol.27 , Issue.9 , pp. 1243-1252
    • Grochova, D.1    Vankova, J.2    Damborsky, J.3    Ravcukova, B.4    Smarda, J.5    Vojtesek, B.6    Smardova, J.7
  • 18
    • 77953564661 scopus 로고    scopus 로고
    • Transactivation by temperature-dependent p53 mutants in yeast and human cells
    • Slovackova J, Grochova D, Navratilova J, Smarda J and Smardova J: Transactivation by temperature-dependent p53 mutants in yeast and human cells. Cell Cycle 9: 2141-2148, 2010.
    • (2010) Cell Cycle , vol.9 , pp. 2141-2148
    • Slovackova, J.1    Grochova, D.2    Navratilova, J.3    Smarda, J.4    Smardova, J.5
  • 19
    • 0027430658 scopus 로고
    • Screening patients for heterozygous p53 mutations using a functional assay in yeast
    • DOI 10.1038/ng1093-124
    • Ishioka C, Frebourg T, Yan Yx, Vidal M, Friend SH, Schmidt S and Iggo R: Screening patients for heterozygous p53 mutations using a functional assay in yeast. Nat Genet 5: 124-129, 1993. (Pubitemid 23293446)
    • (1993) Nature Genetics , vol.5 , Issue.2 , pp. 124-129
    • Ishioka, C.1    Frebourg, T.2    Yan, Y.-X.3    Vidal, M.4    Friend, S.H.5    Schmidt, S.6    Iggo, R.7
  • 21
    • 0035183777 scopus 로고    scopus 로고
    • Rare somatic p53 mutation identified in breast cancer: A case report
    • DOI 10.1159/000050597
    • Smardova J, Nemajerova A, Trbusek M, Vagunda V and Kovarik J: Rare somatic p53 mutation identified in breast cancer: a case report. Tumor Biol 22: 59-66, 2001. (Pubitemid 32010738)
    • (2001) Tumor Biology , vol.22 , Issue.2 , pp. 59-66
    • Smardova, J.1    Nemajerova, A.2    Trbusek, M.3    Vagunda, V.4    Kovarik, J.5
  • 22
    • 0029783722 scopus 로고    scopus 로고
    • A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
    • Friedlander P, Haupt Y, Prives C and Oren M: A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol 16: 4961-4971, 1996. (Pubitemid 26272151)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.9 , pp. 4961-4971
    • Friedlander, P.1    Haupt, Y.2    Prives, C.3    Oren, M.4
  • 23
    • 34548131263 scopus 로고    scopus 로고
    • p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
    • DOI 10.1111/j.1432-0436.2006.00158.x
    • Navratilova J, Horvath V, Kozubik A, Lojek A, Lipsick J and Smarda J: p53 arrest growth and induces differentiation of v-Myb-transformed monoblasts. Differentiation 75: 592-604, 2007. (Pubitemid 47301596)
    • (2007) Differentiation , vol.75 , Issue.7 , pp. 592-604
    • Navratilova, J.1    Horvath, V.2    Kozubik, A.3    Lojek, A.4    Lipsick, J.5    Smarda, J.6
  • 24
    • 1542751000 scopus 로고    scopus 로고
    • High frequency of temperature-sensitive mutations of p53 tumor suppressor in acute myeloid leukemia revealed by functional assay in yeast
    • Pavlova S, Mayer J, Koukalova H and Smardova J: High frequency of temperature-sensitive mutations of p53 tumor suppressor in acute myeloid leukemia revealed by functional assay in yeast. Int J Oncol 23: 121-131, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 121-131
    • Pavlova, S.1    Mayer, J.2    Koukalova, H.3    Smardova, J.4
  • 26
    • 0032510341 scopus 로고    scopus 로고
    • Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assay in yeast
    • Flaman JM, Robert V, Lenglet S, Moreau V, Iggo R and Frebourg T: Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assay in yeast. Oncogene 16: 1369-1272, 1998.
    • (1998) Oncogene , vol.16 , pp. 1369-11272
    • Flaman, J.M.1    Robert, V.2    Lenglet, S.3    Moreau, V.4    Iggo, R.5    Frebourg, T.6
  • 27
    • 0035945659 scopus 로고    scopus 로고
    • p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay
    • DOI 10.1038/sj.onc.1204116
    • Inga A, Monti P, Fronza G, Darden T and Resnick M: p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay. Oncogene 20: 501-513, 2001. (Pubitemid 32158230)
    • (2001) Oncogene , vol.20 , Issue.4 , pp. 501-513
    • Inga, A.1    Monti, P.2    Fronza, G.3    Darden, T.4    Resnick, M.A.5
  • 28
    • 0037093247 scopus 로고    scopus 로고
    • Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: Evidence for a precursor lesion
    • Fulci G, Ishii N, Maurici D, Gernert KM, Hainaut P, Kaur B and Van Metr EG: Initiation of human astrocytoma by clonal evolution of cells with progressive los sof p53 functions in a patient with a 283H TP53 germ-line mutation: Evidence for precursor lesion. Cancer Res 62: 2897-2905, 2002. (Pubitemid 34525777)
    • (2002) Cancer Research , vol.62 , Issue.10 , pp. 2897-2905
    • Fulci, G.1    Ishii, N.2    Maurici, D.3    Gernert, K.M.4    Hainaut, P.5    Kaur, B.6    Van Meir, E.G.7
  • 29
    • 0030022559 scopus 로고    scopus 로고
    • Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins
    • DOI 10.1074/jbc.271.7.3917
    • Hansen S, Hupp TR and Lane DP: Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. J Biol Chem 271: 3917-3924, 1996. (Pubitemid 26065715)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.7 , pp. 3917-3924
    • Hansen, S.1    Hupp, T.R.2    Lane, D.P.3
  • 30
    • 0033600873 scopus 로고    scopus 로고
    • Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling
    • Xirodimas DP and Lane DP: Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling. J Biol Chem 274: 28042-28049, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 28042-28049
    • Xirodimas, D.P.1    Lane, D.P.2
  • 31
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD and Pavletich NP: Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355, 1994. (Pubitemid 24259959)
    • (1994) Science , vol.265 , Issue.5170 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.