Cyanidin reduces preadipocyte differentiation and relative ChREBP expression

Journal of Biological Regulators and Homeostatic Agents

Volumn 26, Issue 2, 2012, Pages 253-264

  Pompei, A ^a   Toniato, E ^b   Innocenti, P ^b   D'Alimonte, I ^b   Cellini, C ^b   Mattoscio, D ^b   Cotellese, R ^b   Bosco, D ^a   Ciccarelli, R ^b   Dadorante, V ^c   D'Orazio, N ^b   Martinotti, S ^b,c   Robuffo, Iole ^a  

^a CNR   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c Department of Clinical Pathology   (Italy)

Author keywords

Adipogenesis; C3G; ChREBP; Cyanidin 3 glucoside; Immunoelectron microscopy; Preadipocytes differentiation

Indexed keywords

BETA1 INTEGRIN; BIOLOGICAL MARKER; CD31 ANTIGEN; CD45 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYANIDIN 3 GLUCOSIDE; GLUCOSE; HERMES ANTIGEN; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CHREBP; UNCLASSIFIED DRUG;

ADIPOGENESIS; ADIPOSE TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL SHAPE; CELL STRUCTURE; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOPLASM; DRUG EFFECT; EXPLANT; EXTRACELLULAR MATRIX; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPOGENESIS; MESENCHYME CELL; PROADIPOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RED OIL O STAINING; STAINING; WEIGHT REDUCTION; WESTERN BLOTTING;

ADIPOCYTES; ADIPOGENESIS; ANTHOCYANINS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; HUMANS; LIPID METABOLISM; STEM CELLS;

EID: 84865025962     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006; 55:1537-45. (Pubitemid 44324105)
2. Chudek J, Wiecek A. Adipose tissue, inflammation and endothelial dysfunction. Pharmacol Reports 2006; 58:81-8.
3. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 2001; 280:827-47.
4. Guzik TJ, Mangalat D, Korbut R. Adipocytokines ñ novel link between inflammation and vascular function? Journal of physiology and pharmacology 2006; 57:505-28. (Pubitemid 46096102)
5. Ferder I, Inserra F, Martinez-Maldonado M. Inflammation and the metabolic syndrome: role of angiotensin II and oxidative stress. Curr Hypertens Rep 2006; 8:191-8. (Pubitemid 43853445)
6. Bennett CN, Ross SE, Longo KA, Bajnok L, Hemati N, Johnson KW, Harrison SD, MacDougald OA. Regulation of Wnt signaling during adipogenesis. J Biol Chem 2002; 277:30998-1004. (Pubitemid 34970803)
7. Hamza MS, Pott S, Vega VB, et al. De-novo identification of PPARgamma/RXR binding sitesand direct targets during adipogenesis. PLoS One 2009; 4(3):4907-12.
8. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 1994; 79:1147-56.
9. Hishida T, Nishizuka M, Osada S, Imagawa M. The role of C/EBPdelta in the early stages of adipogenesis. Biochimie 2009; 91(5):654-7.
10. Ishii S, Ilzuka K, Miller BC, and Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. PNAS 2004; 101:15597-602. (Pubitemid 39473533)
11. Iizuka K. ChREBP: a glucose-activated Transcription Factor involved in the development of Metabolic Syndrome. Endocrine Journal 2008; 55:617-24.
12. Postic C, Dentin R, Denechaud PD, Girard J. ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 2007; 27:179-92. (Pubitemid 351373354)
13. Strable MS, Ntambi JM. Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol 2010; 45:199-214.
14. Tsatsos NG, Davies MN, O'Callaghan BL, Towle HC. Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP. Biochem J 2008; 411:261-70. (Pubitemid 351580178)
15. Davies MN, O'Callaghan BL, Towle HC. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. J Biol Chem 2008; 283:24029-38.
16. Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun 2010; 395:395-400.
17. Fukasawa M, Ge Q, Wynn RM, Ishii S, Uyeda K. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Biochem Biophys Res Commun 2010; 391:1166-9.
18. Guo H, Xia M, Zou T, Ling W, Zhong R, Zhang W. Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J Nutr Biochem 2011; 23(4):349-60.
19. Tsuda T, Ueno Y, Aoki H, Koda T, Horio F, Takahashi N, Kawada T, Osawa T. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes.Biochem Biophys Res Commun 2004; 316:149-57. (Pubitemid 38304941)
20. Tsuda T, Ueno Y, Kojo H, Yoshikawa T, Osawa T. Gene expression profile of isolated rat adipocytes treated with anthocyanins Biochim Biophys Acta 2005; 1733:137-47.
21. Sasaki R, Nishimura N, Hoshino H, et al. Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol 2007; 74:1619-27. (Pubitemid 47614965)
22. Mariman EC, Wang P. Adipocyte extracellular matrix composition, dynamics and role in obesity. Cell Mol Life Sci 2010; 67:1277-92.
23. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89:2548-56. (Pubitemid 38766330)
24. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92:347-55. (Pubitemid 40277057)
25. D' Alimonte I, Nargi E, Mastrangelo F, et al. Vascular endothelial growth factor enhances in vitro proliferation and osteogenic differentiation of human dental pulp stem cells. J Biol Regul Homeost Agents 2011; 25:57-69.
26. Sengenès C, Lolmède K, Zakaroff-Girard A, Busse R, Bouloumié A. Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. J Cell Physiol 2002; 205:114-22.
27. Yoshimura K, Shigeura T, Matsumoto D, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006; 208:64-76. (Pubitemid 43848990)
28. LaVecchia C, Tavani A. Fruit and vegetables, and human cancer. EurJ Cancer Prev 1998; 7:3-8.
29. Fimognari C, Berti F, Nusse M, Cantelli Forti G, Hrelia P. In vitro antitumor activity of cyanidin-3-O-beta-glucopyranoside. Chemotherapy 2005; 51:332-5.
30. Harmon AW, Harp JB. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol 2001; 280:807-13.
31. Harmon AW, Patel YM and Harp JB. Genistein inhibits CCAAT/enhancer- binding protein b (C/EBPb) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression. Biochem J 2002; 367:203-8. (Pubitemid 35176907)
32. Tsuda T, Horio F, Uchida K, Aoki H, Osawa T. Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003; 133:2125-30. (Pubitemid 36841527)