Markers of treatment response to methotrexate in rheumatoid arthritis: Where do we stand?

International Journal of Rheumatology

Volumn 2012, Issue , 2012, Pages

  Halilova, Karina I ^a   Brown, Elizabeth E ^b   Morgan, Sarah L ^a   Bridges, S Louis ^a   Hwang, Min Ho ^a   Arnett, Donna K ^b   Danila, Maria I ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTEROID; CYTOKINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; HYDROXYCHLOROQUINE; METHOTREXATE; METHOTREXATE POLYGLUTAMATE; PLASMA PROTEIN; PREDNISOLONE; SALAZOSULFAPYRIDINE;

ANTIINFLAMMATORY ACTIVITY; BONE RADIOGRAPHY; CYTOPENIA; DRUG RESPONSE; ERYTHROCYTE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; HUMAN; IMMUNOMODULATION; JUVENILE RHEUMATOID ARTHRITIS; LIVER FUNCTION TEST; NAUSEA; PHARMACOGENETICS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; STOMATITIS; TREATMENT RESPONSE;

EID: 84864998081     PISSN: 16879260     EISSN: 16879279     Source Type: Journal    
DOI: 10.1155/2012/978396     Document Type: Review

References (65)

1. Morgan S. L., Oster R. A., Lee J. Y., Alarcn G. S., Baggott J. E., The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis Arthritis Rheumatism 2004 50 10 3104 3111 (Pubitemid 39371985)
2. Wessels J. A., Huizinga T. W., Guchelaar H. J., Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis Rheumatology 2008 47 3 249 255 (Pubitemid 351267187)
3. Jeurissen M. E., Boerbooms A. M., Van De Putte L. B., Doesburg W. H., Lemmens A. M., Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis: a randomized, double-blind study Annals of Internal Medicine 1991 114 12 999 1004
4. Krause D., Schleusser B., Herborn G., Rau R., Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis Arthritis Rheumatism 2000 43 1 14 21 (Pubitemid 30368208)
5. Benucci M., Saviola G., Manfredi M., Sarzi-Puttini P., Atzeni F., Cost effectiveness analysis of disease-modifying antirheumatic drugs in rheumatoid arthritis. A systematic review literature International Journal of Rheumatology 2011 2011 6
6. McInnes I. B., Schett G., The pathogenesis of rheumatoid arthritis The New England Journal of Medicine 2011 365 23 2205 2219
7. Weinblatt M. E., Kaplan H., Germain B. F., Block S., Solomon S. D., Merriman R. C., Wolfe F., Wall B., Anderson L., Gall E., Torretti D., Weissman B., Methotrexate in rheumatoid arthritis: a five-year prospective multicenter study Arthritis Rheumatism 1994 37 10 1492 1498
8. Kooloos W. M., Huizinga T. W. J., Guchelaar H. J., Wessels J. A. M., Pharmacogenetics in treatment of rheumatoid arthritis Current Pharmaceutical Design 2010 16 2 164 175
9. McDonagh E. M., Whirl-Carrillo M., Garten Y., Altman R. B., Klein T. E., From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource Biomarkers in Medicine 2011 5 6 795 806
10. Katchamart W., Johnson S., Lin H. J. L., Phumethum V., Salliot C., Bombardier C., Predictors for remission in rheumatoid arthritis patients: a systematic review Arthritis Care and Research 2010 62 8 1128 1143
11. Mori S., Hirose J., Yonemura K., Contribution of HLA-DRB104 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis Clinical Rheumatology 2010 29 12 1357 1366
12. Hider S. L., Silman A. J., Thomson W., Lunt M., Bunn D., Symmons D. P. M., Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis? Annals of the Rheumatic Diseases 2009 68 1 57 62
13. van Vollenhoven R. F., Ernestam S., Geborek P., Petersson I. F., Cster L., Waltbrand E., Zickert A., Theander J., Thrner., Hellstrm H., Teleman A., Dackhammar C., Akre F., Forslind K., Ljung L., Oding R., Chatzidionysiou A., Wrnert M., Bratt J., Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial The Lancet 2009 374 9688 459 466
14. Saevarsdottir S., Wallin H., Seddighzadeh M., Ernestam S., Geborek P., Petersson I. F., Bratt J., Van Vollenhoven R. F., Predictors of response to methotrexate in early DMARD nave rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial Annals of the Rheumatic Diseases 2011 70 3 469 475
15. Takken T., Van der Net J., Helders P. J., Methotrexate for treating juvenile idiopathic arthritis Cochrane Database of Systematic Reviews 2001 3 CD003129
16. Vilca I., Munitis P. G., Pistorio A., Ravelli A., Buoncompagni A., Bica B., Campos L., Hfner R., Hofer M., Ozen S., Huemer C., Bae S. C., Sztajnbok F., Arguedas O., Foeldvari I., Huppertz H. I., Gamir M. L., Magnusson B., Dressler F., Uziel Y., Van Rossum M. A. J., Hollingworth P., Cawkwell G., Martini A., Ruperto N., Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial Annals of the Rheumatic Diseases 2010 69 8 1479 1483
17. FDA,. Arthritis Advisory Committee Meeting, 2012, http://www.fda.gov/ downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ ArthritisAdvisoryCommittee/UCM302958.pdf
18. Sesin C. A., Bingham C. O. III, Remission in rheumatoid arthritis: wishful thinking or clinical reality? Seminars in Arthritis and Rheumatism 2005 35 3 185 196
19. van der Heijde D., Remission by imaging in rheumatoid arthritis: should this be the ultimate goal? Annals of the Rheumatic Diseases 2012 71 supplement 2 i89 i92
20. van der Heijde D., Klareskog L., Landewé R., Bruyn G. A. W., Cantagrel A., Durez P., Herrero-Beaumont G., Molad Y., Codreanu C., Valentini G., Zahora R., Pedersen R., MacPeek D., Wajdula J., Fatenejad S., Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis Arthritis Rheumatism 2007 56 12 3928 3939 (Pubitemid 350262318)
21. Klareskog L., van der Heijde D., De Jager J. P., Gough A., Kalden J., Malaise M., Martn Mola E., Pavelka K., Sany J., Settas L., Wajdula J., Pedersen R., Fatenejad S., Sanda M., Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial The Lancet 2004 363 9410 675 681 (Pubitemid 38296553)
22. Mandl P., Balint P. V., Brault Y., Metrologic properties of ultrasound versus clinical evaluation of synovitis in rheumatoid arthritis: results of a multicenter, randomized study Arthritis Rheumatism 2012 64 4 1272 1282
23. Taylor P. C.,. Qualification of Ultrasonography as a Biomarker of Prognosis and Response to Treatment in Early Rheumatoid Arthritis, 2012, http://clinicaltrials.gov/ct2/show/NCT00781989?term=NCT00781989rank=1
24. Dhn U. M., Ejbjerg B., Boonen A., Hetland M. L., Hansen M. S., Knudsen L. S., Hansen A., Madsen O. R., Hasselquist M., Mller J. M., stergaard M., No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study Annals of the Rheumatic Diseases 2011 70 2 252 258
25. Gerards A. H., de Lathouder S., de Groot E. R., Dijkmans B. A. C., Aarden L. A., Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis Rheumatology 2003 42 10 1189 1196 (Pubitemid 37258482)
26. Aggarwal A., Misra R., Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis Rheumatology International 2003 23 3 134 137 (Pubitemid 36712990)
27. Miranda-Cars M. E., Balsa A., Benito-Miguel M., De Ayala C. P., Martn-Mola E., IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate Journal of Immunology 2004 173 2 1463 1476 (Pubitemid 38924328)
28. Seitz M., Zwicker M., Villiger P. M., Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different American College of Rheumatology response groups to methotrexate Journal of Rheumatology 2003 30 1 28 35 (Pubitemid 36077768)
29. Maillefert J. F., Puéchal X., Falgarone G., Lizard G., Ornetti P., Solau E., Legré V., Lioté F., Sibilia J., Morel J., Maynadié M., Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis Joint Bone Spine 2010 77 6 558 563
30. Dervieux T., Greenstein N., Kremer J., Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis Arthritis Rheumatism 2006 54 10 3095 3103 (Pubitemid 44622078)
31. Becker M. L., Van Haandel L., Gaedigk R., Lasky A., Hoeltzel M., Stobaugh J., Steven Leeder J., Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations Arthritis Rheumatism 2010 62 6 1803 1812
32. Dalrymple J. M., Stamp L. K., O'Donnell J. L., Chapman P. T., Zhang M., Barclay M. L., Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis Arthritis Rheumatism 2008 58 11 3299 3308
33. Baggott J. E., Vaughn W. H., Hudson B. B., Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide Biochemical Journal 1986 236 1 193 200 (Pubitemid 16095531)
34. Danila M. I., Hughes L. B., Brown E. E., Morgan S. L., Baggott J. E., Arnett D. K., Bridges S. L., Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis? Current Rheumatology Reports 2010 12 5 342 347
35. Stamp L. K., Barclay M. L., O'Donnell J. L., Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritis The Journal of Rheumatology 2011 38 12 2540 2547
36. Dervieux T., Zablocki R., Kremer J., Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis Rheumatology 2010 49 12 2337 2345
37. Stamp L. K., O'Donnell J. L., Chapman P. T., Zhang M., Frampton C., James J., Barclay M. L., Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment Arthritis Rheumatism 2009 60 8 2248 2256
38. Dervieux T., Furst D., Lein D. O., Capps R., Smith K., Walsh M., Kremer J., Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis Arthritis Rheumatism 2004 50 9 2766 2774 (Pubitemid 39209513)
39. Dervieux T., Furst D., Lein D. O., Capps R., Smith K., Caldwell J., Kremer J., Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study Annals of the Rheumatic Diseases 2005 64 8 1180 1185 (Pubitemid 41113353)
40. Hobl E. L., Jilma B., Erlacher L., A short-chain methotrexate polyglutamate as outcome parameter in rheumatoid arthritis patients receiving methotrexate Clinical and Experimental Rheumatology 2012 30 2 156 163
41. Stamp L. K., O'Donnell J. L., Chapman P. T., Zhang M., James J., Frampton C., Barclay M. L., Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy Arthritis Rheumatism 2010 62 2 359 368
42. Stamp L. K., Roberts R. L., Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases Pharmacogenomics 2011 12 10 1449 1463
43. Goronzy J. J., Matteson E. L., Fulbright J. W., Warrington K. J., Chang-Miller A., Hunder G. G., Mason T. G., Nelson A. M., Valente R. M., Crowson C. S., Erlich H. A., Reynolds R. L., Swee R. G., O'Fallon W. M., Weyand C. M., Prognostic markers of radiographic progression in early rheumatoid arthritis Arthritis Rheumatism 2004 50 1 43 54 (Pubitemid 38084286)
44. Wagner U., Kaltenhuser S., Sauer H., Arnold S., Seidel W., Hntzschel H., Kalden J. R., Wassmuth R., HLA markers and prediction of clinical course and outcome in rheumatoid arthritis Arthritis Rheumatism 1997 40 2 341 351 (Pubitemid 27114098)
45. Turesson C., Matteson E. L., Genetics of rheumatoid arthritis Mayo Clinic Proceedings 2006 81 1 94 101 (Pubitemid 43054987)
46. Criswell L. A., Lum R. F., Turner K. N., Woehl B., Zhu Y., Wang J., Tiwari H. K., Edberg J. C., Kimberly R. P., Moreland L. W., Seldin M. F., Bridges S. L., The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept Arthritis Rheumatism 2004 50 9 2750 2756 (Pubitemid 39209511)
47. O'Dell J. R., Nepom B. S., Haire C., Gersuk V. H., Gaur L., Moore G. F., Drymalski W., Palmer W., Eckhoff P. J., Klassen L. W., Wees S., Thiele G., Nepom G. T., HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments Annals of the Rheumatic Diseases 1998 57 4 209 213 (Pubitemid 28323261)
48. Grabar P. B., Rojko S., Logar D., Dolan V., Genetic determinants of methotrexate treatment in rheumatoid arthritis patients: a study of polymorphisms in the adenosine pathway Annals of the Rheumatic Diseases 2010 69 5 931 932
49. Wessels J. A., van der Kooij S. M., Le Cessie S., Kievit W., Barerra P., Allaart C. F., Huizinga T. W. J., Guchelaar H. J., A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis Arthritis Rheumatism 2007 56 6 1765 1775 (Pubitemid 47110376)
50. Hinks A., Moncrieffe H., Martin P., Ursu S., Lal S., Kassoumeri L., Weiler T., Glass D. N., Thompson S. D., Wedderburn L. R., Thomson W., Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis Annals of the Rheumatic Diseases 2011 70 8 1395 1400
51. Sharma S., Das M., Kumar A., Marwaha V., Shankar S., Singh P., Raghu P., Aneja R., Grover R., Arya V., Dhir V., Gupta R., Kumar U., Juyal R. C., B.k. T. T., Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among North Indians Pharmacogenetics and Genomics 2009 19 10 823 828
52. Lee Y. C., Cui J., Costenbader K. H., Shadick N. A., Weinblatt M. E., Karlson E. W., Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate Rheumatology 2009 48 6 613 617
53. Firestein G. S., Paine M. M., Boyle D. L., Mechanisms of methotrexate action in rheumatoid arthritis: selective decrease in synovial collagenase gene expression Arthritis Rheumatism 1994 37 2 193 200 (Pubitemid 24065493)
54. Hupl T., Yahyawi M., Lbke C., Ringe J., Rohrlach T., Burmester G. R., Sittinger M., Kaps C., Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs Journal of Biomolecular Screening 2007 12 3 328 340 (Pubitemid 46514675)
55. Constantin A., Loubet-Lescoulié P., Lambert N., Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction Arthritis Rheumatism 1998 41 1 48 57 (Pubitemid 28041922)
56. Galligan C. L., Baig E., Bykerk V., Keystone E. C., Fish E. N., Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity Genes and Immunity 2007 8 6 480 491 (Pubitemid 47365614)
57. Hobl E. L., Mader R. M., Erlacher L., The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid arthritis Clinical and Experimental Rheumatology 2011 29 6 963 969
58. Grcevic D., Jajic Z., Kovacic N., Lukic I. K., Velagic V., Grubiic F., Ivcevic S., Maruic A., Peripheral blood expression profiles of bone morphogenetic proteins, tumor necrosis factor-superfamily molecules, and transcription factor Runx2 could be used as markers of the form of arthritis, disease activity, and therapeutic responsiveness Journal of Rheumatology 2010 37 2 246 256
59. TcLand E.,. Validation Study of RA-INF-Dx, a Multigene Molecular Test Used to Predict Non-Response to INfliximab Therapy (PRINT), 2012, http://www.clinicaltrials.gov/ct2/show/NCT01299545?term=PRINTrank=2
60. Bridges S. L. Jr., Personalized medicine in rheumatoid arthritis: hopes and challenges Bulletin of the NYU Hospital for Joint Diseases 2007 65 3 174 177
61. Plenge R. M., Bridges S. L. Jr., Personalized medicine in rheumatoid arthritis: miles to go before we sleep Arthritis Rheumatism 2011 63 3 590 593
62. Bridges S. L. Jr.,. Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository (TETRAD), 2012, http://www.clinicaltrials.gov/ ct2/show/NCT01070121?term=TETRADrank=1
63. Ioan-Facsinay A., Willemze A., Robinson D. B., Peschken C. A., Markland J., Van Der Woude D., Elias B., Ménard H. A., Newkirk M., Fritzler M. J., Toes R. E. M., Huizinga T. W. J., El-Gabalawy H. S., Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease Arthritis Rheumatism 2008 58 10 3000 3008
64. Longo D. M., Louie B., Putta S., Single-cell network profiling of peripheral blood mononuclear cells from healthy donors reveals age- and race-associated differences in immune signaling pathway activation The Journal of Immunology 2012 188 4 1717 1725
65. Chibnik L. B., Keenan B. T., Cui J., Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset PLoS One 2011 6 9