Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: Analysis of the PRINTO methotrexate trial

Annals of the Rheumatic Diseases

Volumn 69, Issue 8, 2010, Pages 1479-1483

  Vilca, Iris ^a   Munitis, Pablo Garcia ^a   Pistorio, Angela ^b   Ravelli, Angelo ^b   Buoncompagni, Antonella ^a   Bica, Blanca ^c   Campos, Lucia ^d   Häfner, Renate ^e   Hofer, Michael ^f   Ozen, Seza ^g   Huemer, Christian ^h   Bae, Sang Cheol ⁱ   Sztajnbok, Flavio ^j   Arguedas, Olga ^a   Foeldvari, Ivan ^k   Huppertz, Hans Iko ^l   Gamir, Maria Luz ^m   Magnusson, Bo ⁿ   Dressler, Frank ^o   Uziel, Yosef ^p   Van Rossum, Marion A J ^q   Hollingworth, Peter ^r   Cawkwell, Gail ^s   Martini, Alberto ^b   Ruperto, Nicolino ^a   more..

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e German Center for Pediatric and Adolescent Rheumatology   (Germany)

^f LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^g HACETTEPE UNIVERSITY   (Turkey)

^h Landeskrankenhaus Bregenz   (Austria)

ⁱ Hanyang University Hospital for Rheumatic Diseases   (South Korea)

^j HOSPITAL UNIVERSITÁRIO PEDRO ERNESTO   (Brazil)

^k Hamburger Zentrum fur Kinder und Jugendrheumatologie   (Germany)

^l Department Hess Kinderklinik   (Germany)

^m HOSPITAL RAMÓN Y CAJAL   (Spain)

ⁿ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^o HANNOVER MEDICAL SCHOOL   (Germany)

^p HAEMEK MEDICAL CENTER   (Israel)

^q EMMA CHILDREN S HOSPITAL   (Netherlands)

^r NORTH BRISTOL NHS TRUST   (United Kingdom)

^s North Bristol NHS Trust ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ARTICLE; BIVARIATE ANALYSIS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; JUVENILE RHEUMATOID ARTHRITIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; ONSET AGE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 77955450480     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.120840     Document Type: Article

References (30)

1. Giannini EH, Brewer EJ, Kuzmina N, et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. N Engl J Med 1992;326:1043-9.
2. Ruperto N, Murray KJ, Gerloni V, et al. A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 2004;50:2191-201. (Pubitemid 38924397)
3. Woo P, Southwood TR, Prieur AM, et al. Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthritis Rheum 2000;43:1849-57.
4. Lovell DJ, Giannini EH, Reiff A, et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N Engl J Med 2000;342:763-9.
5. Ruperto N, Lovell DJ, Cuttica R, et al. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 2007;56:3096-106. (Pubitemid 47502757)
6. Ruperto N, Lovell DJ, Quartier P, et al. Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial. Lancet 2008;372:383-91.
7. Lovell DJ, Ruperto N, Goodman S, et al. Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med 2008;359:810-20.
8. Ravelli A, Martini A. Methotrexate in juvenile idiopathic arthritis: answers and questions. J Rheumatol 2000;27:1830-3. (Pubitemid 30670474)
9. Ravelli A, Viola S, Migliavacca D, et al. The extended oligoarticular subtype is the best predictor of methotrexate efficacy in juvenile idiopathic arthritis. J Pediatr 1999;135:316-20. (Pubitemid 30180504)
10. Céspedes-Cruz A, Gutiérrez-Suárez R, Pistorio A, et al. Methotrexate improves the health-related quality of life of children with juvenile idiopathic arthritis. Ann Rheum Dis 2008;67:309-14.
11. Ruperto N, Martini A. International research networks in pediatric rheumatology: the PRINTO perspective. Curr Opin Rheumatol 2004;16:566-70. (Pubitemid 39128326)
12. Petty RE, Southwood TR, Baum J, et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 1998;25:1991-4. (Pubitemid 28459316)
13. Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004;31:390-2. (Pubitemid 38160763)
14. Giannini EH, Ruperto N, Ravelli A, et al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 1997;40:1202-9. (Pubitemid 27430130)
15. Bartoli M, Tarò M, Magni-Manzoni S, et al. The magnitude of early response to methotrexate therapy predicts long-term outcome of patients with juvenile idiopathic arthritis. Ann Rheum Dis 2008;67:370-4. (Pubitemid 351281273)
16. Ravelli A, Ramenghi B, Di Fuccia G, et al. Factors associated with response to methotrexate in systemic-onset juvenile chronic arthritis. Acta Paediatr 1994;83:428-32. (Pubitemid 24136715)
17. Halle F, Prieur AM. Evaluation of methotrexate in the treatment of juvenile chronic arthritis according to the subtype. Clin Exp Rheumatol 1991;9:297-302.
18. Felici E, Novarini C, Magni-Manzoni S, et al. Course of joint disease in patients with antinuclear antibody-positive juvenile idiopathic arthritis. J Rheumatol 2005;32:1805-10. (Pubitemid 41324824)
19. Ruperto N, Levinson JE, Ravelli A, et al. Long-term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis. I. Outcome status. J Rheumatol 1997;24:945-51. (Pubitemid 27223633)
20. Ruperto N, Ravelli A, Levinson JE, et al. Long-term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis. II. Early predictors of outcome. J Rheumatol 1997;24:952-8. (Pubitemid 27223634)
21. Magni-Manzoni S, Pistorio A, Labò E, et al. A longitudinal analysis of physical functional disability over the course of juvenile idiopathic arthritis. Ann Rheum Dis 2008;67:1159-64.
22. Oliveira S, Ravelli A, Pistorio A, et al. Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: the Pediatric Rheumatology International Trials Organization multinational quality of life cohort study. Arthritis Rheum 2007;57:35-43. (Pubitemid 46256722)
23. Magni-Manzoni S, Rossi F, Pistorio A, et al. Prognostic factors for radiographic progression, radiographic damage, and disability in juvenile idiopathic arthritis. Arthritis Rheum 2003;48:3509-17. (Pubitemid 37531917)
24. Cassone R, Falcone A, Rossi F, et al. Unilateral destructive wrist synovitis in juvenile idiopathic arthritis. Clin Exp Rheumatol 2004;22:637-42. (Pubitemid 39302944)
25. Al-Matar MJ, Petty RE, Tucker LB, et al. The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis. Arthritis Rheum 2002;46:2708-15.
26. Oen K. Long-term outcomes and predictors of outcomes for patients with juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol 2002;16:347-60. (Pubitemid 36526648)
27. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007;369:767-78.
28. Anderson JJ, Wells G, Verhoeven AC, et al. Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration. Arthritis Rheum 2000;43:22-9. (Pubitemid 30368209)
29. Pincus T, Sokka T, Kavanaugh A. Relative versus absolute goals of therapies for RA: ACR 20 or ACR 50 responses versus target values for "near remission" of DAS or single measures. Clin Exp Rheumatol 2004;22(5 Suppl 35):S50-6.
30. Reiff A, Shaham B, Wood BP, et al. High dose methotrexate in the treatment of refractory juvenile rheumatoid arthritis. Clin Exp Rheumatol 1995;13:113-18.