Merkel cell carcinoma: The prognostic implications of an occult primary in stage IIIB (nodal) disease

Journal of the American Academy of Dermatology

Volumn 67, Issue 3, 2012, Pages 395-399

  Foote, Matthew ^a   Veness, Michael ^b   Zarate, Dannie ^c   Poulsen, Michael ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c QUEENSLAND HEALTH   (Australia)

Author keywords

Merkel cell carcinoma; nodes; radiotherapy; staging

Indexed keywords

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; AUSTRALIA; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MERKEL CELL TUMOR; OCCULT CANCER; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; RECURRENCE FREE SURVIVAL; RETROSPECTIVE STUDY; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, MERKEL CELL; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; NEOPLASMS, UNKNOWN PRIMARY; PROGNOSIS; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84864993036     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.09.009     Document Type: Article

References (30)

1. M. Poulsen Merkel cell carcinoma of the skin Lancet Oncol 5 2004 593 599
2. L. Fang, B. Lemos, J. Douglas, J. Iyer, and P. Nghiem Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma Cancer 116 2010 1783 1790
3. B. Lemos, B. Storer, J. Iyer, J. Phillips, C. Bichakjian, and C. Fang Pathological nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system J Am Acad Dermatol 10 2010 1 11
4. C.K. Bichakjian, L. Lowe, C.D. Lao, H.M. Sandler, C.R. Bradford, and T.M. Johnson Merkel cell carcinoma: critical review with guidelines for multidisciplinary management Cancer 110 2007 1 12 (Pubitemid 46986412)
5. P.J. Allen, Z.F. Zhang, and D.G. Coit Surgical management of Merkel cell carcinoma Ann Surg 229 1999 97 105 (Pubitemid 30190386)
6. M. Foote, J. Harvey, S. Porceddu, G. Dickie, S. Hewitt, and S. Colquist Effect of radiotherapy dose and volume of relapse in Merkel cell cancer of the skin Int J Radiat Oncol Biol Phys 77 2009 677 684
7. M. Veness, M. Foote, V. Gebski, and M. Poulsen The role of radiotherapy alone in patients with Merkel cell carcinoma: reporting the Australian experience of 43 patients Int J Radiat Oncol Biol Phys 78 2010 703 709
8. H.T. Eich, D. Eich, S. Staar, and C. Mauch Role of postoperative radiotherapy in the management of Merkel cell Am J Clin Oncol 25 2002 50 56 (Pubitemid 34133952)
9. A. Senchenkov, S.A. Barnes, and S.L. Moran Predictors of survival and recurrence in the surgical treatment of Merkel cell carcinoma of the extremities J Surg Oncol 95 2007 229 234
10. M.J. Veness, G. Morgan, and V. Gebski Adjuvant locoregional radiotherapy as best practice in patients with Merkel cell carcinoma of the head and neck Head Neck 27 2005 208 216 (Pubitemid 40315769)
11. M.J. Veness, L. Perera, J. McCourt, J. Shannon, T. Hughes, and G. Morgan Merkel cell carcinoma: improved outcome with adjuvant radiotherapy ANZ J Surg 75 2005 275 281 (Pubitemid 40826890)
12. P. Mojica, D. Smith, and J.D.I. Ellenhorn Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin J Clin Oncol 25 2007 1043 1047 (Pubitemid 46596754)
13. P.J. Allen, W.B. Bowne, D.P. Jaques, M.F. Brennan, K. Busam, and D.G. Coit Merkel cell carcinoma: prognosis and treatment from a single institution J Clin Oncol 23 2005 2300 2309 (Pubitemid 46218722)
14. M. Poulsen, E. Walpole, J. Harvey, G. Dickie, P. O'Brien, and J. Keller Weekly carboplatin reduces toxicity during synchronous chemoradiotherapy for Merkel cell carcinoma of the skin Int J Radiat Oncol Biol Phys 72 2008 1070 1074
15. J.R. Clark, M.J. Veness, R. Gilbert, C.J. O'Brien, and P.J. Gullane Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary? Head Neck 29 2007 249 257 (Pubitemid 46339322)
16. A. Yiengpruksawan, D. Coit, H. Thaler, C. Urmacher, and W. Knapper Merkel cell carcinoma: prognosis and management Arch Surg 126 1991 1514 1519
17. S.B. Edge, and C.C. Compton The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM Ann Surg Oncol 17 2010 1471 1474
18. A. Hui, A. Stillie, M. Seel, and J. Ainslie Merkel cell carcinoma: 27 year experience at the Peter MacCallum Cancer Centre Int J Radiat Oncol Biol Phys 80 2011 1430 1435
19. T.J. Brown, B.A. Jackson, D.F. Macfarlane, and L.H. Goldberg Merkel cell carcinoma: spontaneous resolution and management of metastatic Dermatol Surg 25 1999 23 25 (Pubitemid 29242728)
20. H. Kubo, S. Matsushita, T. Fukushige, T. Kanzaki, and T. Kanekura Spontaneous regression of recurrent and metastatic Merkel cell carcinoma J Dermatol 34 2007 773 777 (Pubitemid 350029298)
21. G. Sais, C. Admella, and T. Soler Spontaneous regression in primary cutaneous neuroendocrine (Merkel cell) carcinoma: a rare immune phenomenon? J Eur Acad Dermatol Venereol 16 2002 82 83 (Pubitemid 34202013)
22. I. Yanguas, J. Goday, M. Gonzalez-Guemes, J. Oleaga, M. Lozano, and R. Soloeta Spontaneous regression of Merkel cell carcinoma of the skin Br J Dermatol 137 1997 296 298 (Pubitemid 27333371)
23. M. Poulsen, D. Rischin, E. Walpole, J. Harvey, J. Mackintosh, and J. Ainslie High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study, TROG 96 07. J Clin Oncol 21 2003 4371 4376 (Pubitemid 46621814)
24. + lymphocyte invasion as an independent predictor of survival J Clin Oncol 29 2011 1539 1546
25. J.C. Wooff, J.R. Trites, N.M. Walsh, and M.J. Bullock Complete spontaneous regression of metastatic Merkel cell carcinoma: a case report and review of the literature Am J Dermatopathol 32 2010 614 617
26. H. Feng, M. Shuda, Y. Chang, and P. Moore Clonal integration of polyomavirus in human Merkel cell carcinoma Science 319 2008 1096 1099
27. K.M. Garneski, A.H. Warcola, Q. Feng, N.B. Kiviat, J.H. Leonard, and P. Nghiem Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors J Invest Dermatol 129 2008 246 248
28. H. Sihto, V. Kukko, R. Sankila, T. Bohling, and H. Joensuu Clinical factors associated with Merkel cell carcinoma polyomavirus infection in Merkel cell carcinoma J Natl Cancer Inst 101 2009 938 945
29. K.K. Ang, J. Harris, R. Wheeler, R. Weber, D. Rosenthal, and P. Nguyen-Tan Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 2010 24 35
30. A. Touze, E. Le Bidre, H. Laude, M. Fleury, R. Cazal, and F. Arnold High levels of antibodies against Merkel cell polyomavirus identify a subset of patients with Merkel cell carcinoma with better clinical outcome J Clin Oncol 29 2011 1612 1619