Weekly Carboplatin Reduces Toxicity During Synchronous Chemoradiotherapy for Merkel Cell Carcinoma of Skin

International Journal of Radiation Oncology Biology Physics

Volumn 72, Issue 4, 2008, Pages 1070-1074

  Poulsen, Michael ^a   Walpole, Euan ^a   Harvey, Jennifer ^a   Dickie, Graeme ^b   O'Brien, Peter ^c   Keller, Jacqui ^b   Tripcony, Lee ^b   Rischin, Danny ^d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c NEWCASTLE MATER HOSPITAL   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Carboplatin; Chemoradiotherapy; Etoposide; Merkel cell carcinoma

Indexed keywords

BODY FLUIDS; CHEMOTHERAPY; NETWORK PROTOCOLS; ONCOLOGY; RISK ASSESSMENT; RISK MANAGEMENT; SKIN; TUMORS;

AREA UNDER THE CURVES; CARBOPLATIN; CHEMORADIOTHERAPY; ETOPOSIDE; LYMPH NODES; MERKEL CELL CARCINOMA; MERKEL CELL CARCINOMATA; NEUTROPENIA; RADIATION ONCOLOGIES; SKIN TOXICITIES;

TOXICITY;

CARBOPLATIN; ETOPOSIDE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD TOXICITY; CANCER MORTALITY; CANCER RELAPSE; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; FEBRILE NEUTROPENIA; FEMALE; HUMAN; LYMPH NODE; MALE; NAUSEA; ONCOLOGY; PRIORITY JOURNAL; RADIATION DOSE; SKIN CANCER; SKIN TOXICITY; TUMOR LOCALIZATION;

AGED; ANTINEOPLASTIC AGENTS; CARBOPLATIN; CARCINOMA, MERKEL CELL; CHROMOSOMAL PROTEINS, NON-HISTONE; COMBINED MODALITY THERAPY; DROSOPHILA PROTEINS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MIDDLE AGED; PILOT PROJECTS; RADIATION TOLERANCE; RADIODERMATITIS; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 54049104306     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.02.076     Document Type: Article

References (9)

1. Veness M. Improved outcome with the addition of adjuvant therapy. J Clin Oncol 25 (2005) 7235-7237
2. Poulsen M., Rischin D., Porter E., et al. Does chemotherapy improve the survival in high risk Merkel cell carcinoma of the skin?. Int J Radiat Oncol Biol Phys 64 (2006) 114-119
3. Poulsen M., Walpole E., Harvey J., et al. High risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: A Trans-Tasman Radiation Oncology Group study, TROG 96:07. J Clin Oncol 21 (2003) 4371-4376
4. Calvert A.H., Newell D.R., Gumbrell S., et al. Carboplatin dosage: Prospective evaluation of a simple formula based on renal function. J Clin Oncol 7 (1989) 1748-1756
5. Decker R.H., and Wilson L.D. Role of radiotherapy in the management of Merkel cell carcinoma. JNCCN 4 (2006) 713-718
6. Medina-Franco H., Urist M.M., Fiveash J., et al. Multimodality treatment of Merkel cell carcinoma: Case series and review of 1024 cases. Ann Surg Oncol 8 (2001) 204-208
7. Goessling W., McKee P.H., and Mayer R. Merkel cell carcinoma. J Clin Oncol 20 (2002) 588-598
8. Tai P.T., Yu E., Winquist E., et al. Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin and review of 204 cases. J Clin Oncol 18 (2000) 2493-2499
9. Poulsen M., Rischin D., Walpole E., et al. Analysis of toxicity of Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: A Trans-Tasman Radiation Oncology Group study. Int J Radiat Oncol Biol Phys 51 (2001) 156-163