Novel in situ pretreatment method for significantly enhancing the signal in MALDI-TOF MS of formalin-fixed paraffin-embedded tissue sections

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Kakimoto, Yu ^a   Tsuruyama, Tatsuaki ^a   Yamamoto, Takushi ^b   Furuta, Masaru ^b   Kotani, Hirokazu ^a   Ozeki, Munetaka ^a   Yoshizawa, Akihiko ^c   Haga, Hironori ^d   Tamaki, Keiji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SHIMADZU CORPORATION   (Japan)

^c SHINSHU UNIVERSITY HOSPITAL   (Japan)

^d KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; BIOLOGICAL MARKER; FORMALDEHYDE; HISTONE H2A; PARAFFIN;

ADULT; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; COLON CARCINOMA; COMPRESSED AIR; CONTROLLED STUDY; FEMALE; HEATING; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTEIN ANALYSIS; SIGNAL DETECTION; TISSUE SECTION; VAPOR PRESSURE;

BIOLOGICAL MARKERS; COLONIC NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; PARAFFIN EMBEDDING; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE FIXATION;

EID: 84864985857     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041607     Document Type: Article

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