Risk factors for lymph node metastasis in pT1 and pT2 rectal cancer: A single-institute experience in 943 patients and literature review

Annals of Surgical Oncology

Volumn 19, Issue 8, 2012, Pages 2477-2484

  Chang, Hao Cheng ^a   Huang, Shih Chiang ^a   Chen, Jinn Shiun ^a   Tang, Reiping ^a   Changchien, Chung Rong ^a   Chiang, Jy Ming ^a   Yeh, Chien Yuh ^a   Hsieh, Pao Shiu ^a   Tsai, Wen Sy ^a   Hung, Hsin Yuan ^a   You, Jeng Fu ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; CANCER INVASION; CANCER STAGING; CANCER SURGERY; FEMALE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; RECTUM CARCINOMA; REVIEW; RISK FACTOR; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; RECTAL NEOPLASMS; REVIEW LITERATURE AS TOPIC; SURVIVAL RATE; YOUNG ADULT;

EID: 84864973825     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-012-2303-9     Document Type: Review

References (39)

1. DL Beral JR Monson 2005 Is local excision of T2/T3 rectal cancers adequate? Recent Results Cancer Res. 165 120 135 15865027 10.1007/3-540-27449-9- 14 1:STN:280:DC%2BD2M3jtVKjsg%3D%3D
2. Y Kajiwara H Ueno Y Hashiguchi H Mochizuki K Hase 2010 Risk factors of nodal involvement in T2 colorectal cancer Dis Colon Rectum. 53 1393 1399 20847621 10.1007/DCR.0b013e3181ec5f66
3. DJ Bentrem S Okabe WD Wong, et al. 2005 T1 adenocarcinoma of the rectum: transanal excision or radical surgery? Ann Surg. 242 472 479 16192807
4. BH Endreseth HE Myrvold P Romundstad UE Hestvik T Bjerkeset A Wibe 2005 Transanal excision vs. major surgery for T1 rectal cancer Dis Colon Rectum. 48 1380 1388 15906120 10.1007/s10350-005-0044-6
5. J Garcia-Aguilar A Mellgren P Sirivongs D Buie RD Madoff DA Rothenberger 2000 Local excision of rectal cancer without adjuvant therapy: a word of caution Ann Surg. 231 345 351 10714627 10.1097/00000658-200003000-00007 1:STN:280:DC%2BD3c7nslWjuw%3D%3D
6. YN You NN Baxter A Stewart H Nelson 2007 Is the increasing rate of local excision for stage I rectal cancer in the United States justified? A nationwide cohort study from the National Cancer Database Ann Surg. 245 726 733 17457165 10.1097/01.sla.0000252590.95116.4f
7. S Coverlizza M Risio A Ferrari CM Fenoglio-Preiser FP Rossini 1989 Colorectal adenomas containing invasive carcinoma. Pathologic assessment of lymph node metastatic potential Cancer. 64 1937 1947 2477139 10.1002/1097-0142(19891101)64:9<1937::AID-CNCR2820640929>3.0.CO;2-X 1:STN:280:DyaK3c%2Fgt1OqtQ%3D%3D
8. SA Norton MG Thomas 1999 Staging of rectosigmoid neoplasia with colonoscopic endoluminal ultrasonography Br J Surg. 86 942 946 10417570 10.1046/j.1365-2168.1999.01188.x 1:STN:280:DyaK1MzkvVKmtA%3D%3D
9. M Chiesura-Corona PC Muzzio G Giust M Zuliani S Pucciarelli P Toppan 2001 Rectal cancer: CT local staging with histopathologic correlation Abdom Imaging. 26 134 138 11178688 10.1007/s002610000154 1:STN:280:DC%2BD3M3ksFahsQ%3D%3D
10. JP Heneghan RR Salem RC Lange KJ Taylor LW Hammers 1997 Transrectal sonography in staging rectal carcinoma: the role of gray-scale, color-flow, and Doppler imaging analysis AJR Am J Roentgenol. 169 1247 1252 9353436 1:STN:280:DyaK1c%2FhsVOlsQ%3D%3D
11. G Brown A Kirkham GT Williams, et al. 2004 High-resolution MRI of the anatomy important in total mesorectal excision of the rectum AJR Am J Roentgenol. 182 431 439 14736677
12. H Kwok IP Bissett GL Hill 2000 Preoperative staging of rectal cancer Int J Colorectal Dis. 15 9 20 10766086 10.1007/s003840050002 1:STN:280: DC%2BD3c3islWmsQ%3D%3D
13. LL Tong P Gao ZN Wang, et al. 2011 Is pT2 subclassification feasible to predict patient outcome in colorectal cancer? Ann Surg Oncol. 18 1389 1396 21107740 10.1245/s10434-010-1440-2
14. H Kobayashi H Mochizuki T Kato, et al. 2010 Is total mesorectal excision always necessary for T1-T2 lower rectal cancer? Ann Surg Oncol. 17 973 980 19953330 10.1245/s10434-009-0849-y
15. JW Huh HR Kim YJ Kim 2010 Lymphovascular or perineural invasion may predict lymph node metastasis in patients with T1 and T2 colorectal cancer J Gastrointest Surg. 14 1074 1080 20431977 10.1007/s11605-010-1206-y
16. Hamilton SR, Bosman FT, Boffetta P, et al. Carcinoma of the colon and rectum. In: Bosman FT, Carneiro F, Hruban RH, Teise ND, editors. WHO classification of tumours of the digestive system. 4th edition. Geneva: World Health Organization, 2010.
17. JT Brodsky GK Richard AM Cohen BD Minsky 1992 Variables correlated with the risk of lymph node metastasis in early rectal cancer Cancer. 69 322 326 1728363 10.1002/1097-0142(19920115)69:2<322::AID-CNCR2820690208>3.0.CO;2-B 1:STN:280:DyaK38%2Fps12lsw%3D%3D
18. JM Geraghty CB Williams IC Talbot 1991 Malignant colorectal polyps: venous invasion and successful treatment by endoscopic polypectomy Gut. 32 774 778 1855684 10.1136/gut.32.7.774 1:STN:280:DyaK3MzgvF2iug%3D%3D
19. HS Cooper 1988 The role of the pathologist in the management of patients with endoscopically removed malignant colorectal polyps Pathol Annu. 23 Pt 1 25 43 3387137
20. EI Harris DN Lewin HL Wang, et al. 2008 Lymphovascular invasion in colorectal cancer: an interobserver variability study Am J Surg Pathol. 32 1816 1821 18779725 10.1097/PAS.0b013e3181816083
21. NS Goldstein J Hart 1999 Histologic features associated with lymph node metastasis in stage T1 and superficial T2 rectal adenocarcinomas in abdominoperineal resection specimens. Identifying a subset of patients for whom treatment with adjuvant therapy or completion abdominoperineal resection should be considered after local excision Am J Clin Pathol. 111 51 58 9894454 1:STN:280:DyaK1M7htFyhtw%3D%3D
22. K Hase C Shatney D Johnson M Trollope M Vierra 1993 Prognostic value of tumor "budding" in patients with colorectal cancer Dis Colon Rectum. 36 627 635 8348847 10.1007/BF02238588 1:STN:280:DyaK3szltFGjsA%3D%3D
23. R Kikuchi M Takano K Takagi, et al. 1995 Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines Dis Colon Rectum. 38 1286 1295 7497841 10.1007/BF02049154 1:STN:280:DyaK287gtFGmuw%3D%3D
24. TJ Saclarides AK Bhattacharyya C Britton-Kuzel D Szeluga SG Economou 1994 Predicting lymph node metastases in rectal cancer Dis Colon Rectum. 37 52 57 8287748 10.1007/BF02047215 1:STN:280:DyaK2c7hs1eqsg%3D%3D
25. C Liebig G Ayala J Wilks, et al. 2009 Perineural invasion is an independent predictor of outcome in colorectal cancer J Clin Oncol. 27 5131 5137 19738119 10.1200/JCO.2009.22.4949
26. SP Huddy EM Husband MG Cook NM Gibbs CG Marks RJ Heald 1993 Lymph node metastases in early rectal cancer Br J Surg. 80 1457 1458 8252364 10.1002/bjs.1800801135 1:STN:280:DyaK2c%2FntlKksg%3D%3D
27. GC Zenni K Abraham FJ Harford DM Potocki C Herman PB Dobrin 1998 Characteristics of rectal carcinomas that predict the presence of lymph node metastases: implications for patient selection for local therapy J Surg Oncol. 67 99 103 9486780 10.1002/(SICI)1096-9098(199802)67:2<99::AID-JSO5>3.0. CO;2-G 1:STN:280:DyaK1c7ks1Wrtw%3D%3D
28. D Blumberg PB Paty JG Guillem, et al. 1999 All patients with small intramural rectal cancers are at risk for lymph node metastasis Dis Colon Rectum. 42 881 885 10411434 10.1007/BF02237095 1:STN:280:DyaK1Mzjslansw%3D%3D
29. T Masaki M Sugiyama Y Atomi, et al. 2001 The indication of local excision for T2 rectal carcinomas Am J Surg. 181 133 137 11425053 10.1016/S0002-9610(00) 00559-6 1:STN:280:DC%2BD3MzmtlGhtQ%3D%3D
30. R Nascimbeni LJ Burgart S Nivatvongs DR Larson 2002 Risk of lymph node metastasis in T1 carcinoma of the colon and rectum Dis Colon Rectum. 45 200 206 11852333 10.1007/s10350-004-6147-7
31. S Bayar R Saxena B Emir RR Salem 2002 Venous invasion may predict lymph node metastasis in early rectal cancer Eur J Surg Oncol. 28 413 417 12099652 10.1053/ejso.2002.1254 1:STN:280:DC%2BD38zlslSgtg%3D%3D
32. T Okuyama M Oya H Ishikawa 2002 Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma Dis Colon Rectum. 45 628 634 12004212 10.1007/s10350-004-6259-0
33. S Okabe J Shia G Nash, et al. 2004 Lymph node metastasis in T1 adenocarcinoma of the colon and rectum J Gastrointest Surg. 8 1032 1040 15585391 10.1016/j.gassur.2004.09.038
34. WL Fang SC Chang JK Lin, et al. 2005 Metastatic potential in T1 and T2 colorectal cancer Hepatogastroenterology. 52 1688 1691 16334758
35. T Masaki H Matsuoka M Sugiyama, et al. 2005 Tumor budding and evidence-based treatment of T2 rectal carcinomas J Surg Oncol. 92 59 63 16180229 10.1002/jso.20369
36. A Ulrich K Himmer M Koch P Kienle MW Buchler J Weitz 2007 Location of rectal cancer within the circumference of the rectum does not influence lymph node status Ann Surg Oncol. 14 2257 2262 17520316 10.1245/s10434-007-9383-y
37. KS Chok WL Law 2007 Prognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal cancer World J Surg. 31 1485 1490 17510767 10.1007/s00268-007-9089-0
38. S Rasheed DM Bowley O Aziz, et al. 2008 Can depth of tumour invasion predict lymph node positivity in patients undergoing resection for early rectal cancer? A comparative study between T1 and T2 cancers Colorectal Dis. 10 231 238 18257848 10.1111/j.1463-1318.2007.01411.x 1:STN:280:DC%2BD1c7gtVGnsw%3D%3D
39. S Ogino K Nosho N Irahara, et al. 2010 Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction Am J Gastroenterol. 105 420 433 19809407 10.1038/ajg.2009.578