Anti-inflammatory treatment increases angiogenesis during early fracture healing

Archives of Orthopaedic and Trauma Surgery

Volumn 132, Issue 8, 2012, Pages 1205-1213

  Lu, Chuanyong ^a,b   Xing, Zhiqing ^a   Wang, Xiaodong ^a   Mao, Jeremy ^b   Marcucio, Ralph S ^a   Miclau, Theodore ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

Angiogenesis; Fracture repair; Indomethacin; Inflammation; NSAID

Indexed keywords

INDOMETACIN; INTERLEUKIN 1BETA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALLUS; CHONDROGENESIS; CONTROLLED STUDY; DISEASE DURATION; DRUG DOSE COMPARISON; FRACTURE HEALING; MACROPHAGE; MALE; MORPHOMETRICS; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; STEREOLOGY; TIBIA FRACTURE; TISSUE LEVEL; TREATMENT DURATION; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; FRACTURE HEALING; INDOMETHACIN; MALE; MICE; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 84864960997     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-012-1525-4     Document Type: Article

References (41)

1. Moghaddam A, Elleser C, Biglari B et al (2010) Clinical application of BMP 7 in long bone non-unions. Arch Orthop Trauma Surg 130(1):71-76
2. Lange J, Sapozhnikova A, Lu C et al (2010) Action of IL-1 beta during fracture healing. J Orthop Res 28(6):778-784
3. Rundle CH, Wang H, Yu H et al (2006) Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair. Bone 38(4):521-529
4. Einhorn TA, Majeska RJ, Rush EB et al (1995) The expression of cytokine activity by fracture callus. J Bone Miner Res 10(8):1272-1281
5. Hauser CJ, Joshi P, Zhou X et al (1996) Production of interleukin-10 in human fracture soft-tissue hematomas. Shock 6(1):3-6
6. Weiss S, Zimmermann G, Pufe T et al (2009) The systemic angiogenic response during bone healing. Arch Orthop Trauma Surg 129(7):989-997
7. Lu C, Miclau T, Hu D et al (2005) Cellular basis for age-related changes in fracture repair. J Orthop Res 23(6):1300-1307
8. Thompson Z, Miclau T, Hu D et al (2002) A model for intramembranous ossification during fracture healing. J Orthop Res 20(5):1091-1098
9. O'Connor JP, Lysz T (2008) Celecoxib, NSAIDs and the skeleton. Drugs Today (Barc) 44(9):693-709
10. Hausman MR, Schaffler MB, Majeska RJ (2001) Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29(6):560-564
11. Zhang X, Schwarz EM, Young DA et al (2002) Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109(11):1405-1415
12. Mullis BH, Copland ST, Weinhold PS et al (2006) Effect of COX-2 inhibitors and non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury 37(9):827-837
13. Simon AM, O'Connor JP (2007) Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Jt Surg Am 89(3):500-511
14. Murnaghan M, Li G, Marsh DR (2006) Nonsteroidal antiinflammatory drug-induced fracture nonunion: an inhibition of angiogenesis? J Bone Jt Surg Am 88(Suppl 3):140-147
15. Leonelli SM, Goldberg BA, Safanda J et al (2006) Effects of a cyclooxygenase-2 inhibitor (rofecoxib) on bone healing. Am J Orthop (Belle Mead NJ) 35(2):79-84
16. Karachalios T, Boursinos L, Poultsides L et al (2007) The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits. J Bone Jt Surg Br 89(9):1253-1260
17. Cullinane DM, Salisbury KT, Alkhiary Y et al (2003) Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development? J Exp Biol 206(Pt 14):2459-2471
18. Endo K, Sairyo K, Komatsubara S et al (2005) Cyclooxygenase-2 inhibitor delays fracture healing in rats. Acta Orthop 76(4):470- 474
19. Elves MW, Bayley I, Roylance PJ (1982) The effect of indomethacin upon experimental fractures in the rat. Acta Orthop Scand 53(1):35-41
20. Brown KM, Saunders MM, Kirsch T et al (2004) Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Jt Surg Am 86A(1):116-123
21. Bo J, Sudmann E, Marton PF (1976) Effect of indomethacin on fracture healing in rats. Acta Orthop Scand 47(6):588-599
22. Altman RD, Latta LL, Keer R et al (1995) Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma 9(5):392-400
23. Allen HL, Wase A, Bear WT (1980) Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand 51(4):595-600
24. Engesaeter LB, Sudmann B, Sudmann E (1992) Fracture healing in rats inhibited by locally administered indomethacin. Acta Orthop Scand 63(3):330-333
25. Reuben SS, Ablett D, Kaye R (2005) High dose nonsteroidal antiinflammatory drugs compromise spinal fusion. Can J Anaesth 52(5):506-512
26. Glassman SD, Rose SM, Dimar JR et al (1998) The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine(Phila Pa 1976) 23(7):834-838
27. Giannoudis PV, MacDonald DA, Matthews SJ et al (2000) Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Jt Surg Br 82(5): 655-658
28. Bhattacharyya T, Levin R, Vrahas MS et al (2005) Nonsteroidal antiinflammatory drugs and nonunion of humeral shaft fractures. Arthr Rheum 53(3):364-367
29. Burd TA, Hughes MS, Anglen JO (2003) Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion. J Bone Jt Surg Br 85(5):700-705
30. Sudmann E, Dregelid E, Bessesen A et al (1979) Inhibition of fracture healing by indomethacin in rats. Eur J Clin Invest 9(5):333-339
31. Lu C, Marcucio R, Miclau T (2006) Assessing angiogenesis during fracture healing. Iowa Orthop J 26:17-26
32. Lu C, Hansen E, Sapozhnikova A et al (2008) Effect of age on vascularization during fracture repair. J Orthop Res 26(10): 1384-1389
33. Howard CV, Reed MG (1998) Unbiased stereology: threedimensional measurement in microscopy, Springer, New York Inc., pp 107-132
34. Dockery P, Fraher J (2007) The quantification of vascular beds: a stereological approach. Exp Mol Pathol 82(2):110-120
35. Lee CH, Cook JL, Mendelson A et al (2010) Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet 376(9739):440-448
36. Lu C, Saless N, Hu D et al (2011) Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma 25(8):494-499
37. Noonan DM, De Lerma Barbaro A, Vannini N et al (2008) Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Cancer Metastasis Rev 27(1):31-40
38. Sieff CA, Tsai S, Faller DV (1987) Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest 79(1):48-51
39. Finetti F, Solito R, Morbidelli L et al (2008) Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1. J Biol Chem 283(4):2139-2146
40. Szczesny G, Olszewski WL, Zagozda M et al (2011) Genetic factors responsible for long bone fractures non-union. Arch Orthop Trauma Surg 131(2):275-281
41. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM et al (2007) Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after shortterm treatment. J Bone Jt Surg Am 89(1):114-125