Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

Chemistry Central Journal

Volumn 6, Issue 1, 2012, Pages

  Borcan, Florin ^a   Soica, Codruta M ^a   Ganta, Srinivas ^b   Amiji, Mansoor M ^b   Dehelean, Cristina A ^a   Munteanu, Melania F ^c  

^a VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b NORTHEASTERN UNIVERSITY   (United States)

^c VASILE GOLDIS WESTERN UNIVERSITY OF ARAD   (Romania)

Author keywords

CD1Nu Nu mice; Drug delivery; Hollow microstructures; Lysine diisocyanate ester; Noxiousness; Polyurethane; Zeta potential

Indexed keywords

EID: 84864956394     PISSN: None     EISSN: 1752153X     Source Type: Journal    
DOI: 10.1186/1752-153X-6-87     Document Type: Article

References (38)

1. Rihova B. Biocompatibility of biomaterials: hemocompatibility, immunocompatiblity and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers. Adv Drug Deliv Rev 1996, 21(2):157-176.
2. McNeil SE. Unique benefits of nanotechnology to drug delivery and diagnostics in: characterization of nanoparticles intended for drug delivery. Methods in Molecular Biology Series 2011, 697. New York: Humana Press, Walker JM, Part 1: 3-8.
3. Brewer M, Zhang T, Dong W, Rutherford M, Ryan Tian Z. Future approaches of nanomedicine in clinical science. Med Clin North Am 2007, 91(5):963-1016. 10.1016/j.mcna.2007.05.006, 17826113.
4. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 2001, 70:1-20. 10.1016/S0168-3659(00)00339-4, 11166403.
5. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010, 75:1-18. 10.1016/j.colsurfb.2009.09.001, 19782542.
6. Piticescu RM, Popescu LM, Buruiana T. Composites containing hydroxyapatite and polyurethane ionomers as bone substitution materials. Dig J Nano Bio 2012, 7:477-485.
7. Sokolsky-Papkov M, Agashi K, Olaye A, Shakesheff K, Domb AJ. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev 2007, 59:187-206. 10.1016/j.addr.2007.04.001, 17540473.
8. Bonzani IC, Adhikari R, Houshyar S, Mayadunne R, Gunatillake P, Stevens MM. Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials 2007, 28(3):423-433. 10.1016/j.biomaterials.2006.08.026, 16979756.
9. Snodgrass HR, . VistaGen, Inc Toxicity typing using mesenchymal stem cells 2002, Publication number: US Patent, 0045179 A1, VistaGen, Inc.
10. Guelcher SA, Gallagher KM, Didier JE, Klinedinst DB, Doctor JS, Goldstein AS, Wilkes GL, Beckman EJ, Hollinger JO. Synthesis of biocompatible segmented polyurethanes from aliphatic diisocyanates and diurea diol chain extenders. Acta Biomater 2005, 1(4):471-484. 10.1016/j.actbio.2005.02.007, 16701828.
11. Kligman AM, Kligman LH. A hairless mouse model for assessing the chronic toxicity of topically applied chemicals. Food Chem Toxicol 1998, 36:867-878. 10.1016/S0278-6915(98)00045-3, 9737434.
12. Almeida JS, Benvegn DM, Boufleur N, Reckziegel P, Barcelos RC, Coradini K, de Carvalho LM, Burger ME, Beck RC. Hydrogels containing rutin intended for cutaneous administration: efficacy in wound healing in rats. Drug Dev Ind Pharm 2012, 38(7):792-799. 10.3109/03639045.2011.628676, 22066462.
13. Kim D, Kim E, Lee J, Hong S, Sung W, Lim N, Park CG, Kim K. Direct synthesis of polymer nanocapsules: self-assembly of polymer hollow spheres through irreversible covalent bond formation. J Am Chem Soc 2010, 132(28):9908-9919. 10.1021/ja1039242, 20572658.
14. Liu X, Basu A. Core functionalization of hollow polymer nanocapsules. J Am Chem Soc 2009, 131(16):5718-5719. 10.1021/ja809619w, 19351114.
15. Bolzinger M-A, Briançon S, Chevalier Y. Nanoparticles through the skin: managing conflicting results of inorganic and organic particles in cosmetics and pharmaceutics. WIREs Nanomed Nanobiotechnol 2011, 3:463-478.
16. Prow TW, Grice JE, Lin LL, Faye R, Butler M, Becker W, Wurm EM, Yoong C, Robertson TA, Soyer HP, Roberts MS. Nanoparticles and microparticles for skin drug delivery. Adv Drug Deliv Rev 2011, 63(6):470-491. 10.1016/j.addr.2011.01.012, 21315122.
17. Zhang Y, Zhao J, Jiang M, Wang J. Generalization of in-situ polymerization method for preparing core-shell polymeric nanospheres and hollow spheres. Front Chem China 2007, 2(3):287-291.
18. Royall PG, Craig DQM, Doherty C. Characterisation of the glass transition of an amorphous drug using modulated DSC. Pharm Res 1998, 15:1117-1121. 10.1023/A:1011902816175, 9688069.
19. Gallardo V, Morales ME, Ruiz MA, Delgado AV. An experimental investigation of the stability of ethylcellulose latex. Correlation between zeta potential and sedimentation. Eur J Pharm Sci 2005, 26:170-175. 10.1016/j.ejps.2005.05.008, 16005193.
20. Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 2003, 5:32-45. 154434, 12716446.
21. McBride J, Ingram PR, Henriquez FL, Roberts CW. Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba. J Clin Microbiol 2005, 43:629-634. 10.1128/JCM.43.2.629-634.2005, 548097, 15695656.
22. Zeidman T, Parush R, Massad N, Segal E. Compatibility of cancer cells with nanostructured oxidized porous silicon substrates. Phys Status Solidi C 2011, 8(6):1903-1907.
23. Mortensen LJ, Oberdorster G, Pentland AP, DeLouise L. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett 2008, 8(9):2779-2787. 10.1021/nl801323y, 18687009.
24. Dehelean CA. Toxicologie. Notiuni generale de toxicologie / Toxicology. General notions of toxicology 2008, Timisoara: Ed. Mirton.
25. Peters JM. Studies of isocyanate toxicity. Proc R Soc Med 1970, 63(4):372-375. 1811207, 5441968.
26. Bucher JR, Gupta BN, Adkins B, Thompson M, Jameson CW, Thigpen JE, Schwetz BA. The toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies. Environ Health Persp 1987, 72:53-61.
27. Koch PJ, de Viragh PA, Scharer E, Bundman D, Longley MA, Bickenbach J, Kawachi Y, Suga Y, Zhou Z, Huber M, Hohl D, Kartasova T, Jarnik M, Steven AC, Roop DR. Lessons from Loricrin-deficient Mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol 2000, 151(2):389-400. 10.1083/jcb.151.2.389, 2192642, 11038185.
28. Tanriverdi F, Borlu M, Atmaca H, Koc CA, Unluhizarci K, Utas S, Kelestimur F. Investigation of the skin characteristics in patients with severe GH deficiency and the effects of 6months of GH replacement therapy: a randomized placebo controlled study. Clin Endocrinol 2006, 65:579-585.
29. Atrux-Tallau N, Romagny C, Padois K, Denis A, Haftek M, Falson F, Pirot F, Maibach HI. Effects of glycerol on human skin damaged by acute sodium lauryl sulphate treatment. Arch Dermatol Res 2010, 302:435-441. 10.1007/s00403-009-1021-z, 20043170.
30. Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol 2001, 117:44-51. 10.1046/j.0022-202x.2001.01399.x, 11442748.
31. Yilmaz E, Borchert H-H. Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema-An in vivo study. Int J Pharm 2006, 307:232-238. 10.1016/j.ijpharm.2005.10.002, 16289984.
32. Russell NS, Knaken H, Bruinvis IAD, Hart AAM, Begg AC, Lebesque JV JV. Quantification of patient to patient variation of skin erythema developing as a response to radiotherapy. Radiother Oncol 1994, 30(3):213-221. 10.1016/0167-8140(94)90460-X, 8209004.
33. Bouchemal K, Briancon S, Perrier E, Fessi H, Bonnet I, Zydowick N. Synthesis and characterization of polyurethane and poly(ether urethane) nanocapsules using a new technique of interfacial polycondensation combined to spontaneous emulsification. Int J Pharm 2004, 269:89-100. 10.1016/j.ijpharm.2003.09.025, 14698580.
34. Seymour RW, Cooper SL. Thermal Analysis of Polyurethane Block Polymers. Macromol 1973, 6(1):48-53.
35. Rogiers V, . EEMCO Group EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001, 14(2):117-128. 10.1159/000056341, 11316970, EEMCO Group.
36. MPA5-PH905 Manual http://www.courage-khazaka.de.
37. MPA5-MX18 Manual http://www.courage-khazaka.de.
38. MPA5-TM300 Manual http://www.courage-khazaka.de.