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Volumn 25, Issue 3, 2012, Pages 529-539

Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice

Author keywords

Experimental autoimmune encephalomyelitis (EAE); IL 10; IL 17; IL 2; T cell proliferation; Zinc aspartate

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; TRACE ELEMENT; UNCLASSIFIED DRUG; UNIZINK; ZINC; ZINC ASPARTATE;

EID: 84864913192     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-012-9532-z     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • doi:10.1038/ni0407-345
    • Bettelli E, Oukka M, Kuchroo VK (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8(4):345-350. doi:10.1038/ni0407-345
    • (2007) Nat Immunol , vol.8 , Issue.4 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 2
    • 80054905005 scopus 로고    scopus 로고
    • Divergent actions by inhibitors of DP IV and APN family enzymes on CD4? Teff cell motility and functions
    • Biton A, Ansorge S, Bank U, Täger M, Reinhold D, Brocke S (2011) Divergent actions by inhibitors of DP IV and APN family enzymes on CD4? Teff cell motility and functions. Immunobiology 216(12):1295-1301
    • (2011) Immunobiology , vol.216 , Issue.12 , pp. 1295-1301
    • Biton, A.1    Ansorge, S.2    Bank, U.3    Täger, M.4    Reinhold, D.5    Brocke, S.6
  • 3
    • 0025239795 scopus 로고
    • The physiological role of zinc as an antioxidant
    • Bray TM, Bettger WJ (1990) The physiological role of zinc as an antioxidant. Free Radic Biol Med 8(3):281-291
    • (1990) Free Radic Biol Med , vol.8 , Issue.3 , pp. 281-291
    • Bray, T.M.1    Bettger, W.J.2
  • 4
    • 0030174575 scopus 로고    scopus 로고
    • Isolation and characterization of autoreactive T cells in experimental autoimmune encephalomyelitis of the mouse
    • Brocke S, Quigley L, McFarland HF, Steinman L (1996) Isolation and characterization of autoreactive T cells in experimental autoimmune encephalomyelitis of the mouse. Methods 9(3):458-462
    • (1996) Methods , vol.9 , Issue.3 , pp. 458-462
    • Brocke, S.1    Quigley, L.2    McFarland, H.F.3    Steinman, L.4
  • 5
    • 0030845070 scopus 로고    scopus 로고
    • Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons
    • Cakman I, Kirchner H, Rink L (1997) Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons. J Interferon Cytokine Res 17(8):469-472
    • (1997) J Interferon Cytokine Res , vol.17 , Issue.8 , pp. 469-472
    • Cakman, I.1    Kirchner, H.2    Rink, L.3
  • 7
    • 33645991187 scopus 로고    scopus 로고
    • Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells
    • doi:10.1016/j.nut.2005.11.009
    • Chang KL, Hung TC, Hsieh BS, Chen YH, Chen TF, Cheng HL (2006) Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells. Nutrition 22(5): 465-474. doi:10.1016/j.nut.2005.11.009
    • (2006) Nutrition , vol.22 , Issue.5 , pp. 465-474
    • Chang, K.L.1    Hung, T.C.2    Hsieh, B.S.3    Chen, Y.H.4    Chen, T.F.5    Cheng, H.L.6
  • 8
    • 79956116032 scopus 로고    scopus 로고
    • RORct drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • doi: 10.1038/ni.2027
    • Codarri L, Gyülvészi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B (2011) RORct drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12(6):560-567. doi: 10.1038/ni.2027
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 560-567
    • Codarri, L.1    Gyülvészi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 9
    • 1642513783 scopus 로고    scopus 로고
    • Genetics of multiple sclerosis
    • doi: 10.1016/S1474-4422(03)00663-X
    • Dyment DA, Ebers GC, Sadovnick AD (2004) Genetics of multiple sclerosis. Lancet Neurol 3(2):104-110. doi: 10.1016/S1474-4422(03)00663-X
    • (2004) Lancet Neurol , vol.3 , Issue.2 , pp. 104-110
    • Dyment, D.A.1    Ebers, G.C.2    Sadovnick, A.D.3
  • 10
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF
    • doi:10.1038/ni.2031
    • El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A (2011) The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12(6):568-575. doi:10.1038/ni.2031
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6    Zhang, G.X.7    Dittel, B.N.8    Rostami, A.9
  • 11
    • 3242655603 scopus 로고    scopus 로고
    • Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response
    • doi:10.1038/sj.bmt.1704509
    • Faber C, Gabriel P, Ibs KH, Rink L (2004) Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response. Bone Marrow Transplant 33(12):1241-1246. doi:10.1038/sj.bmt.1704509
    • (2004) Bone Marrow Transplant , vol.33 , Issue.12 , pp. 1241-1246
    • Faber, C.1    Gabriel, P.2    Ibs, K.H.3    Rink, L.4
  • 12
    • 28444468799 scopus 로고    scopus 로고
    • Statistical analysis of data fromstudies on experimental autoimmune encephalomyelitis
    • doi:10.1016/j.jneuroim.2005.08.020
    • FlemingKK, Bovaird JA,MosierMC, EmersonMR, LeVine SM, Marquis JG(2005)Statistical analysis of data fromstudies on experimental autoimmune encephalomyelitis. J Neuroimmunol 170(1-2):71-84. doi:10.1016/j.jneuroim.2005. 08.020
    • (2005) J Neuroimmunol , vol.170 , Issue.1-2 , pp. 71-84
    • Fleming, K.K.1    Bovaird, J.A.2    Mosier, M.C.3    Emerson, M.R.4    Levine, S.M.5    Marquis, J.G.6
  • 13
    • 0025121927 scopus 로고
    • Zinc toxicity
    • Fosmire GJ (1990) Zinc toxicity. Am J Clin Nutr 51(2):225-227
    • (1990) Am J Clin Nutr , vol.51 , Issue.2 , pp. 225-227
    • Fosmire, G.J.1
  • 14
    • 80755140105 scopus 로고    scopus 로고
    • Zinc homeostasis and signaling in health and diseases: Zinc signaling
    • doi:10.1007/s00775-011-0797-4
    • Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T (2011) Zinc homeostasis and signaling in health and diseases: zinc signaling. J Biol Inorg Chem 16(7):1123-1134. doi:10.1007/s00775-011-0797-4
    • (2011) J Biol Inorg Chem , vol.16 , Issue.7 , pp. 1123-1134
    • Fukada, T.1    Yamasaki, S.2    Nishida, K.3    Murakami, M.4    Hirano, T.5
  • 15
    • 61749093508 scopus 로고    scopus 로고
    • RORct drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • doi:10.1172/JCI35997
    • Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, Waisman A (2009) RORct drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. J Clin Invest 119(1):61-69. doi:10.1172/JCI35997
    • (2009) J Clin Invest , vol.119 , Issue.1 , pp. 61-69
    • Haak, S.1    Croxford, A.L.2    Kreymborg, K.3    Heppner, F.L.4    Pouly, S.5    Becher, B.6    Waisman, A.7
  • 16
    • 33645376448 scopus 로고    scopus 로고
    • Immunopathogenesis and immunotherapy of multiple sclerosis
    • doi: 10.1038/ncpneuro0154
    • Hemmer B, Nessler S, Zhou D, Kieseier B, Hartung HP (2006) Immunopathogenesis and immunotherapy of multiple sclerosis. Nat Clin Pract Neurol 2(4):201-211. doi: 10.1038/ncpneuro0154
    • (2006) Nat Clin Pract Neurol , vol.2 , Issue.4 , pp. 201-211
    • Hemmer, B.1    Nessler, S.2    Zhou, D.3    Kieseier, B.4    Hartung, H.P.5
  • 17
    • 30944452780 scopus 로고    scopus 로고
    • Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    • doi: 10.1016/j.cellimm.2005.11.002
    • Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, Toyka KV, Gold R (2005) Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol 237(2):123-130. doi: 10.1016/j.cellimm.2005.11.002
    • (2005) Cell Immunol , vol.237 , Issue.2 , pp. 123-130
    • Hofstetter, H.H.1    Ibrahim, S.M.2    Koczan, D.3    Kruse, N.4    Weishaupt, A.5    Toyka, K.V.6    Gold, R.7
  • 18
    • 33846558558 scopus 로고    scopus 로고
    • Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice
    • Hofstetter HH, Toyka KV, Tary-Lehmann M, Lehmann PV (2007) Kinetics and organ distribution of IL-17-producing CD4 cells in proteolipid protein 139-151 peptide-induced experimental autoimmune encephalomyelitis of SJL mice. J Immunol 178(3):1372-1378
    • (2007) J Immunol , vol.178 , Issue.3 , pp. 1372-1378
    • Hofstetter, H.H.1    Toyka, K.V.2    Tary-Lehmann, M.3    Lehmann, P.V.4
  • 19
    • 0038670770 scopus 로고    scopus 로고
    • Zinc-altered immune function
    • Ibs KH, Rink L (2003) Zinc-altered immune function. J Nutr 133(5 Suppl 1):146S-1452S
    • (2003) J Nutr , vol.133 , Issue.5 SUPPL. 1
    • Ibs, K.H.1    Rink, L.2
  • 20
  • 21
    • 0025069608 scopus 로고
    • Zinc deficiency and immune function
    • doi:10.1146/ annurev.nu.10.070190.002215
    • Keen CL, Gershwin ME (1990) Zinc deficiency and immune function. Annu Rev Nutr 10:415-431. doi:10.1146/ annurev.nu.10.070190.002215
    • (1990) Annu Rev Nutr , vol.10 , pp. 415-431
    • Keen, C.L.1    Gershwin, M.E.2
  • 23
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177(1):566-573
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6    Sudo, K.7    Iwakura, Y.8
  • 24
    • 84864935886 scopus 로고    scopus 로고
    • Leopold IH (1981) United States Patent 4,255,419
    • Leopold IH (1981) United States Patent 4,255,419
  • 26
    • 0033662509 scopus 로고    scopus 로고
    • Metallothionein i ? II expression and their role in experimental autoimmune encephalomyelitis
    • doi:10.1002/1098-1136(200 012 32:3\247:AID-GLIA50[3.0.CO;2-T
    • Penkowa M, Hidalgo J (2000) Metallothionein I ? II expression and their role in experimental autoimmune encephalomyelitis. Glia 32(3):247-263. doi:10.1002/1098-1136(200 012)32:3\247:AID-GLIA50[3.0.CO;2-T
    • (2000) Glia 32 , vol.3 , pp. 247-263
    • Penkowa, M.1    Hidalgo, J.2
  • 27
    • 0017769982 scopus 로고
    • Anaemia and low serum-copper during zinc therapy
    • doi:10.1016/S0140-6736(77)90295-1
    • Porter KG, McMaster D, Elmes ME, Love AH (1977) Anaemia and low serum-copper during zinc therapy. Lancet 2(8041):774. doi:10.1016/S0140-6736(77) 90295-1
    • (1977) Lancet , vol.2 , Issue.8041 , pp. 774
    • Porter, K.G.1    McMaster, D.2    Elmes, M.E.3    Love, A.H.4
  • 28
    • 0031725436 scopus 로고    scopus 로고
    • Zinc and immunity
    • doi:10.1023/A:1006868305749
    • Prasad AS (1998) Zinc and immunity. Mol Cell Biochem 188(1-2):63-69. doi:10.1023/A:1006868305749
    • (1998) Mol Cell Biochem , vol.188 , Issue.1-2 , pp. 63-69
    • Prasad, A.S.1
  • 29
    • 0033822221 scopus 로고    scopus 로고
    • Effects of zinc deficiency on Th1 and Th2 cytokine shifts
    • doi: 10.1086/315916
    • Prasad AS (2000) Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 182(Suppl 1):S62-S68. doi: 10.1086/315916
    • (2000) J Infect Dis , vol.182 , Issue.SUPPL. 1
    • Prasad, A.S.1
  • 31
    • 4644308853 scopus 로고    scopus 로고
    • Antioxidant effect of zinc in humans
    • doi:10.1016/j.freeradbiomed.2004.07.007
    • Prasad AS, Bao B, Beck FW, Kucuk O, Sarkar FH (2004) Antioxidant effect of zinc in humans. Free Radic Biol Med 37(8):1182-1190. doi:10.1016/j. freeradbiomed.2004.07.007
    • (2004) Free Radic Biol Med , vol.37 , Issue.8 , pp. 1182-1190
    • Prasad, A.S.1    Bao, B.2    Beck, F.W.3    Kucuk, O.4    Sarkar, F.H.5
  • 32
    • 33847788242 scopus 로고    scopus 로고
    • Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress
    • Prasad AS, Beck FW, Bao B, Fitzgerald JT, Snell DC, Steinberg JD, Cardozo LJ (2007) Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 85:837-844
    • (2007) Am J Clin Nutr , vol.85 , pp. 837-844
    • Prasad, A.S.1    Beck, F.W.2    Bao, B.3    Fitzgerald, J.T.4    Snell, D.C.5    Steinberg, J.D.6    Cardozo, L.J.7
  • 33
    • 0030743693 scopus 로고    scopus 로고
    • Zinc regulates DNA synthesis and IL-2, IL-6 and IL-10 production of PWM-stimulated PBMC and normalizes the periphere cytokine concentration in chronic liver disease
    • doi:10.1002/(SICI)1520-670X(1997)10:1\19:AID-JTRA3[3.0.CO;2-#
    • Reinhold D, Ansorge S, Grüngreiff K (1997) Zinc regulates DNA synthesis and IL-2, IL-6 and IL-10 production of PWM-stimulated PBMC and normalizes the periphere cytokine concentration in chronic liver disease. J Trace Elem Exp Med 10:19-27. doi:10.1002/(SICI)1520-670X(1997)10:1\19:AID- JTRA3[3.0.CO;2-#
    • (1997) J Trace Elem Exp Med , vol.10 , pp. 19-27
    • Reinhold, D.1    Ansorge, S.2    Grüngreiff, K.3
  • 34
    • 0032979326 scopus 로고    scopus 로고
    • Immunobiology of zinc and zinc therapy
    • doi: 10.1016/S0167-5699(98)01400-5
    • Reinhold D, Ansorge S, Grüngreiff K (1999) Immunobiology of zinc and zinc therapy. Immunol Today 20(2):102-103. doi: 10.1016/S0167-5699(98)01400-5
    • (1999) Immunol Today , vol.20 , Issue.2 , pp. 102-103
    • Reinhold, D.1    Ansorge, S.2    Grüngreiff, K.3
  • 35
    • 79953302035 scopus 로고    scopus 로고
    • PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N(APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice
    • doi: 10.1515/BC.2011.024
    • Reinhold D, Bank U, Entz D, Goihl A, Stoye D, Wrenger S, Brocke S, Thielitz A, Stefin S, Nordhoff K, Heimburg A, Täger M, Ansorge S (2011) PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N(APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice. Biol Chem 392(3):233-237. doi: 10.1515/BC.2011.024
    • (2011) Biol Chem , vol.392 , Issue.3 , pp. 233-237
    • Reinhold, D.1    Bank, U.2    Entz, D.3    Goihl, A.4    Stoye, D.5    Wrenger, S.6    Brocke, S.7    Thielitz, A.8    Stefin, S.9    Nordhoff, K.10    Heimburg, A.11    Täger, M.12    Ansorge, S.13
  • 36
    • 33845617033 scopus 로고    scopus 로고
    • Zinc homeostasis and immunity
    • doi:10.1016/j.it.2006.11.005
    • Rink L, Haase H (2007) Zinc homeostasis and immunity. Trends Immunol 28(1):1-4. doi:10.1016/j.it.2006.11.005
    • (2007) Trends Immunol , vol.28 , Issue.1 , pp. 1-4
    • Rink, L.1    Haase, H.2
  • 37
    • 33751254750 scopus 로고    scopus 로고
    • Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
    • doi:10.1002/eji.200636658
    • Röhn TA, Jennings GT, Hernandez M, Grest P, Beck M, Zou Y, Kopf M, Bachmann MF (2006) Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur J Immunol 36(11):2857-2867. doi:10.1002/eji.200636658
    • (2006) Eur J Immunol , vol.36 , Issue.11 , pp. 2857-2867
    • Röhn, T.A.1    Jennings, G.T.2    Hernandez, M.3    Grest, P.4    Beck, M.5    Zou, Y.6    Kopf, M.7    Bachmann, M.F.8
  • 38
    • 0025011471 scopus 로고
    • Effects of altered dietary trace metals upon experimental allergic encephalomyelitis
    • Schiffer RB, Herndon RM, Eskin T (1990) Effects of altered dietary trace metals upon experimental allergic encephalomyelitis. Neurotoxicology 11(3):443-450
    • (1990) Neurotoxicology , vol.11 , Issue.3 , pp. 443-450
    • Schiffer, R.B.1    Herndon, R.M.2    Eskin, T.3
  • 40
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H)17, the first majorrevision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    • doi:10.1038/ nm1551
    • Steinman L (2007) A brief history of T(H)17, the first majorrevision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13(2):139-145. doi:10.1038/ nm1551
    • (2007) Nat Med , vol.13 , Issue.2 , pp. 139-145
    • Steinman, L.1
  • 42
    • 33751243318 scopus 로고    scopus 로고
    • Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis
    • 2874 doi: 10.1002/eji.200636662
    • Uyttenhove C, Van Snick J (2006) Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur J Immunol 36(11):2868 2874. doi: 10.1002/eji.200636662
    • (2006) Eur J Immunol , vol.36 , Issue.11 , pp. 2868
    • Uyttenhove, C.1    Van Snick, J.2
  • 44
    • 33744984785 scopus 로고    scopus 로고
    • Th17 an effector CD4 T cell lineage with regulatory T cell ties
    • doi: 10.1016/j.immuni.2006.06.002
    • Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM (2006) Th17 an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24(6):677-688. doi: 10.1016/j.immuni.2006.06.002
    • (2006) Immunity , vol.24 , Issue.6 , pp. 677-688
    • Weaver, C.T.1    Harrington, L.E.2    Mangan, P.R.3    Gavrieli, M.4    Murphy, K.M.5
  • 45
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • doi: 10.1146/annurev.immunol.25.022106.141557
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-852. doi: 10.1146/annurev.immunol.25.022106.141557
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 46
    • 0031790234 scopus 로고    scopus 로고
    • The significance of zinc for leukocyte biology
    • Wellinghausen N, Rink L (1998) The significance of zinc for leukocyte biology. J Leukoc Biol 64(5):571-577
    • (1998) J Leukoc Biol , vol.64 , Issue.5 , pp. 571-577
    • Wellinghausen, N.1    Rink, L.2
  • 47
    • 0030722996 scopus 로고    scopus 로고
    • The immunobiology of zinc
    • doi: 10.1016/S0167-5699(97)01146-8
    • Wellinghausen N, Kirchner H, Rink L (1997) The immunobiology of zinc. Immunol Today 18(11):519-521. doi: 10.1016/S0167-5699(97)01146-8
    • (1997) Immunol Today , vol.18 , Issue.11 , pp. 519-521
    • Wellinghausen, N.1    Kirchner, H.2    Rink, L.3


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