A low thymic function is associated with leukemia relapse in children given T-cell-depleted HLA-haploidentical stem cell transplantation

Leukemia

Volumn 26, Issue 8, 2012, Pages 1886-1888

  Clave, E ^a   Lisini, D ^b   Douay, C ^a   Giorgiani, G ^b   Busson, M ^a   Zecca, M ^b   Charron, D ^a,c   Bernardo, M E ^d   Toubert, A ^a   Locatelli, F ^d  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c SAINT LOUIS HOSPITAL   (France)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; DNA EXTRACTION; HEMATOLOGIC MALIGNANCY; HUMAN; IMMUNE RESPONSE; LETTER; LEUKEMIA RELAPSE; OUTCOME ASSESSMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK FACTOR; T LYMPHOCYTE; THYMUS;

EID: 84864886195     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.59     Document Type: Letter

References (15)

1. Rocha V, Locatelli F. Searching for alternative hematopoietic stem cell donors for pediatric patients. Bone Marrow Transplant 2008; 41: 207-214.
2. Handgretinger R, Klingebiel T, Lang P, Schumm M, Neu S, Geiselhart A et al. Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant 2001; 27: 777-783.
3. Ball LM, Lankester AC, Bredius RG, Fibbe WE, van Tol MJ, Egeler RM. Graft dysfunction and delayed immune reconstitution following haploidentical peripheral blood hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35 (Suppl 1): S35-S38.
4. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295: 2097-2100.
5. Ciurea SO, Mulanovich V, Jiang Y, Bassett R, Rondon G, McMannis J et al. Lymphocyte recovery predicts outcomes in cord blood and T cell-depleted haploidentical stem cell transplantation. Biol Blood Marrow Transplant 2011; 17: 1169-1175.
6. Talvensaari K, Clave E, Douay C, Rabian C, Garderet L, Busson M et al. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood 2002; 99: 1458-1464.
7. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998; 396: 690-695.
8. Dion ML, Sekaly RP, Cheynier R. Estimating thymic function through quantification of T-cell receptor excision circles. Methods Mol Biol 2007; 380: 197-213.
9. Toubert A, Glauzy S, Douay C, Clave E. Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again. Tissue Antigens 2012; 79: 83-89.
10. Clave E, Busson M, Douay C, Peffault de Latour R, Berrou J, Rabian C et al. Acute graft versus host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation. Blood 2009; 113: 6477-6484.
11. Clave E, Rocha V, Talvensaari K, Busson M, Douay C, Appert ML et al. Prognostic value of pretransplantation host thymic function in HLAidentical sibling hematopoietic stem cell transplantation. Blood 2005; 105: 2608-2613.
12. Chen X, Barfield R, Benaim E, Leung W, Knowles J, Lawrence D et al. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 2005; 105: 886-893.
13. Seggewiss R, Einsele H. Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update. Blood 2010; 115: 3861-3868.
14. Hochberg EP, Chillemi AC, Wu CJ, Neuberg D, Canning C, Hartman K et al. Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults. Blood 2001; 98: 1116-1121.
15. Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011; 11: 330-342.