메뉴 건너뛰기




Volumn 14, Issue 8, 2012, Pages 793-801

Rap2A links intestinal cell polarity to brush border formation

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; EZRIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR PDZGEF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR PDZGEF2; MESSENGER RNA; MST4 KINASE; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE D1; PHOSPHOTRANSFERASE; PROTEIN KINASE LKB1; PROTEIN RAP2A; SHORT HAIRPIN RNA; TNIK KINASE; UNCLASSIFIED DRUG;

EID: 84864869731     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2537     Document Type: Article
Times cited : (88)

References (41)
  • 1
    • 77955501804 scopus 로고    scopus 로고
    • Widely conserved signaling pathways in the establishment of cell polarity
    • McCaffrey, L. M. & Macara, I. G. Widely conserved signaling pathways in the establishment of cell polarity. Cold Spring Harb. Perspect. Biol. 1, a001370 (2009).
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1
    • McCaffrey, L.M.1    MacAra, I.G.2
  • 2
    • 72949115493 scopus 로고    scopus 로고
    • Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
    • Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 326, 1707-1711 (2009).
    • (2009) Science , vol.326 , pp. 1707-1711
    • Zeqiraj, E.1    Filippi, B.M.2    Deak, M.3    Alessi, D.R.4    Van Aalten, D.M.5
  • 3
    • 0038614742 scopus 로고    scopus 로고
    • Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
    • Baas, A. F. et al. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J. 22, 3062-3072 (2003).
    • (2003) EMBO J. , vol.22 , pp. 3062-3072
    • Baas, A.F.1
  • 4
    • 0141753981 scopus 로고    scopus 로고
    • MO25-/-interact with STRAD-/-enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
    • Boudeau, J. et al. MO25-/-interact with STRAD-/-enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 22, 5102-5114 (2003).
    • (2003) EMBO J. , vol.22 , pp. 5102-5114
    • Boudeau, J.1
  • 5
    • 44949122687 scopus 로고    scopus 로고
    • STRAD-regulates LKB1 localization by blocking access to importin-, and by association with Crm1 and exportin-7
    • Dorfman, J. & Macara, I. G. STRAD-regulates LKB1 localization by blocking access to importin-, and by association with Crm1 and exportin-7. Mol. Biol. Cell 19, 1614-1626 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 1614-1626
    • Dorfman, J.1    MacAra, I.G.2
  • 6
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas, A. F. et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116, 457-466 (2004).
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1
  • 8
    • 0027264558 scopus 로고
    • BUD2 encodes a GTPase-Activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast
    • Park, H. O., Chant, J. & Herskowitz, I. BUD2 encodes a GTPase-Activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365, 269-274 (1993).
    • (1993) Nature , vol.365 , pp. 269-274
    • Park, H.O.1    Chant, J.2    Herskowitz, I.3
  • 10
    • 46249118002 scopus 로고    scopus 로고
    • Lifeact: A versatile marker to visualize F-Actin
    • Riedl, J. et al. Lifeact: a versatile marker to visualize F-Actin. Nat. Methods 5, 605-607 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 605-607
    • Riedl, J.1
  • 11
    • 64549137929 scopus 로고    scopus 로고
    • MST4 and Ezrin induce brush borders downstream of the LKB1/STRAD/MO25 polarization complex
    • Ten Klooster, J. P. et al. MST4 and Ezrin induce brush borders downstream of the LKB1/STRAD/MO25 polarization complex. Dev. Cell 16, 551-562 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 551-562
    • Ten Klooster, J.P.1
  • 13
    • 1942533655 scopus 로고    scopus 로고
    • Mitogen-Activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
    • Machida, N. et al. Mitogen-Activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J. Biol. Chem. 279, 15711-15714 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 15711-15714
    • MacHida, N.1
  • 14
    • 10344249427 scopus 로고    scopus 로고
    • The Traf2-And Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
    • Taira, K. et al. The Traf2-And Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton. J. Biol. Chem. 279, 49488-49496 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 49488-49496
    • Taira, K.1
  • 15
    • 80053262749 scopus 로고    scopus 로고
    • Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control
    • Pannekoek, W. J. et al. Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cell Signal 23, 2056-2064 (2011).
    • (2011) Cell Signal , vol.23 , pp. 2056-2064
    • Pannekoek, W.J.1
  • 17
    • 70450246902 scopus 로고    scopus 로고
    • PIP5K-driven PtdIns(4;5)P2 synthesis: Regulation and cellular functions
    • Van den Bout, I. & Divecha, N. PIP5K-driven PtdIns(4;5)P2 synthesis: regulation and cellular functions. J. Cell Sci. 122, 3837-3850 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 3837-3850
    • Van Den Bout, I.1    Divecha, N.2
  • 18
    • 0033231049 scopus 로고    scopus 로고
    • Identi-cation of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes
    • Sciorra, V. A. et al. Identi-cation of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J. 18, 5911-5921 (1999).
    • (1999) EMBO J. , vol.18 , pp. 5911-5921
    • Sciorra, V.A.1
  • 19
    • 0033985026 scopus 로고    scopus 로고
    • Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-speci-c PH domain
    • Hodgkin, M. N. et al. Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-speci-c PH domain. Curr. Biol. 10, 43-46 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 43-46
    • Hodgkin, M.N.1
  • 20
    • 0041671075 scopus 로고    scopus 로고
    • Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs
    • Du, G. et al. Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs. J. Cell Biol. 162, 305-315 (2003).
    • (2003) J. Cell Biol. , vol.162 , pp. 305-315
    • Du, G.1
  • 21
    • 34547612218 scopus 로고    scopus 로고
    • Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage
    • Zeniou-Meyer, M. et al. Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage. J. Biol. Chem. 282, 21746-21757 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 21746-21757
    • Zeniou-Meyer, M.1
  • 22
    • 55549099554 scopus 로고    scopus 로고
    • MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
    • Nonaka, H. et al. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Biochem. Biophys. Res. Commun. 377, 573-578 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 573-578
    • Nonaka, H.1
  • 23
    • 2942626080 scopus 로고    scopus 로고
    • Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1
    • Gobel, V., Barrett, P. L., Hall, D. H. & Fleming, J. T. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Dev. Cell 6, 865-873 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 865-873
    • Gobel, V.1    Barrett, P.L.2    Hall, D.H.3    Fleming, J.T.4
  • 24
    • 33846270032 scopus 로고    scopus 로고
    • PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
    • Martin-Belmonte, F. et al. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 128, 383-397 (2007).
    • (2007) Cell , vol.128 , pp. 383-397
    • Martin-Belmonte, F.1
  • 25
    • 34447568476 scopus 로고    scopus 로고
    • Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
    • Zhao, C., Du, G., Skowronek, K., Frohman, M. A. & Bar-Sagi, D. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat. Cell Biol. 9, 706-712 (2007).
    • (2007) Nat. Cell Biol. , vol.9 , pp. 706-712
    • Zhao, C.1    Du, G.2    Skowronek, K.3    Frohman, M.A.4    Bar-Sagi, D.5
  • 26
    • 43249100633 scopus 로고    scopus 로고
    • Membrane-dependent signal integration by the Ras activator Son of sevenless
    • Gureasko, J. et al. Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat. Struct. Mol. Biol. 15, 452-461 (2008).
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 452-461
    • Gureasko, J.1
  • 27
    • 65249117435 scopus 로고    scopus 로고
    • Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis
    • Nishikimi, A. et al. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science 324, 384-387 (2009).
    • (2009) Science , vol.324 , pp. 384-387
    • Nishikimi, A.1
  • 28
    • 79251476231 scopus 로고    scopus 로고
    • Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment
    • Matsuki, T. et al. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell 143, 826-836 (2010).
    • (2010) Cell , vol.143 , pp. 826-836
    • Matsuki, T.1
  • 29
    • 1842613600 scopus 로고    scopus 로고
    • YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta
    • Preisinger, C. et al. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. J. Cell Biol. 164, 1009-1020 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 1009-1020
    • Preisinger, C.1
  • 30
    • 33747623042 scopus 로고    scopus 로고
    • Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
    • Katagiri, K., Imamura, M. & Kinashi, T. Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat. Immunol. 7, 919-928 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 919-928
    • Katagiri, K.1    Imamura, M.2    Kinashi, T.3
  • 31
    • 4344594485 scopus 로고    scopus 로고
    • The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
    • Schwamborn, J. C. & Puschel, A. W. The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat. Neurosci. 7, 923-929 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 923-929
    • Schwamborn, J.C.1    Puschel, A.W.2
  • 32
    • 79952237532 scopus 로고    scopus 로고
    • Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory
    • Lee, K. J. et al. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Neuron 69, 957-973 (2011).
    • (2011) Neuron , vol.69 , pp. 957-973
    • Lee, K.J.1
  • 33
    • 46849095863 scopus 로고    scopus 로고
    • The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions
    • Dube, N. et al. The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. Cell Signal 20, 1608-1615 (2008).
    • (2008) Cell Signal , vol.20 , pp. 1608-1615
    • Dube, N.1
  • 34
    • 66349090219 scopus 로고    scopus 로고
    • Direct spatial control of Epac1 by cAMP
    • Ponsioen, B. et al. Direct spatial control of Epac1 by cAMP. Mol. Cell Biol. 29, 2521-2531 (2009).
    • (2009) Mol. Cell Biol. , vol.29 , pp. 2521-2531
    • Ponsioen, B.1
  • 35
    • 0034689050 scopus 로고    scopus 로고
    • The small GTPase, Rap1, mediates CD31-induced integrin adhesion
    • Reedquist, K. A. et al. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J. Cell Biol. 148, 1151-1158 (2000).
    • (2000) J. Cell Biol. , vol.148 , pp. 1151-1158
    • Reedquist, K.A.1
  • 36
    • 0035805510 scopus 로고    scopus 로고
    • Monitoring agonist-induced phospholipase C activation in live cells by-uorescence resonance energy transfer
    • Van der Wal, J., Habets, R., Varnai, P., Balla, T. & Jalink, K. Monitoring agonist-induced phospholipase C activation in live cells by-uorescence resonance energy transfer. J. Biol. Chem. 276, 15337-15344 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 15337-15344
    • Van Der Wal, J.1    Habets, R.2    Varnai, P.3    Balla, T.4    Jalink, K.5
  • 37
    • 0037178885 scopus 로고    scopus 로고
    • Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130
    • Varnai, P. et al. Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J. Biol. Chem. 277, 27412-27422 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 27412-27422
    • Varnai, P.1
  • 39
    • 0034981546 scopus 로고    scopus 로고
    • Measurement of GTP-bound Ras-like GTPases by activation-speci-c probes
    • Van Triest, M., de Rooij, J. & Bos, J. L. Measurement of GTP-bound Ras-like GTPases by activation-speci-c probes. Methods Enzymol. 333, 343-348 (2001).
    • (2001) Methods Enzymol. , vol.333 , pp. 343-348
    • Van Triest, M.1    De Rooij, J.2    Bos, J.L.3
  • 40
    • 0035976615 scopus 로고    scopus 로고
    • Phos-phatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A. & Chen, J. Phos-phatidic acid-mediated mitogenic activation of mTOR signaling. Science 294, 1942-1945 (2001).
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 41
    • 77950195991 scopus 로고    scopus 로고
    • Binding of GAPR-1 to negatively charged phospholipid membranes: Unusual binding characteristics to phosphatidylinositol
    • Van Galen, J. et al. Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol. Mol. Membr. Biol. 27, 81-91.
    • Mol. Membr. Biol. , vol.27 , pp. 81-91
    • Van Galen, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.