High TSH and low T4 as prognostic markers in older patients

Hormones

Volumn 11, Issue 3, 2012, Pages 350-355

  Mingote, Evelin ^a   Meroño, Tomás ^b   Rujelman, Rocío ^a   Marquez, Alejandra ^a   Fossati, Pia ^a   Gurfinkiel, Mirta ^a   Schnitman, Marta ^a   Brites, Fernando ^b   Faingold, Cristina ^a   Brenta, Gabriela ^a  

^a Unidad Asistencial Dr César Milstein   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Elderly patients; Hospitalization; Hypothyroidism; Non thyroidal illness; Thyroid hormones

Indexed keywords

THYROTROPIN; THYROXINE;

ADULT; AGE; AGED; AGED HOSPITAL PATIENT; ARTICLE; CLINICAL ASSESSMENT TOOL; CLINICAL FEATURE; CONFIDENCE INTERVAL; DISEASE SEVERITY; EUTHYROIDISM; FEMALE; FOLLOW UP; GENDER; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; PATIENT CODING; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; SUBCLINICAL HYPERTHYROIDISM; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION; THYROID FUNCTION TEST;

EID: 84864840296     PISSN: 11093099     EISSN: None     Source Type: Journal    
DOI: 10.14310/horm.2002.1364     Document Type: Article

References (18)

1. van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW, 2005 Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90: 6403-6409.
2. Mariotti S, Franceschi C, Cossarizza A, Pinchera A, 1995 The aging thyroid. Endocr Rev 16: 686-715.
3. Surks MI, Hollowell JG, 2007 Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab 92: 4575-4582.
4. A ssociation of Clinical Biochemistry, BTAaBTF, 2006 UK Guidelines for the Use of Thyroid Function Tests. ACB and BTA, London. http://www.british-thyroidassociation. org/info-for-patients/Docs/TFT_.
5. I glesias P, Munoz, A, Prado F, et al, 2009 Alterations in thyroid function tests in aged hospitalized patients: prevalence, aetiology and clinical outcome. Clin Endocrinol (Oxf) 70: 961-967.
6. Tognini S, Marchini F, Dardano A, et al, 2010 Nonthyroidal illness syndrome and short-term survival in a hospitalised older population. Age Ageing 39: 46-50.
7. Stathatos N, Wartofsky L, 2003 The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? J Endocrinol Invest 26: 1174-1179.
8. Gussekloo J, van Exel E, de Craen AJ, et al, 2004 Thyroid status, disability and cognitive function, and survival in old age. JAMA 292: 2591-2599.
9. Baloch Z, Carayon P, Conte-Devolx B, et al, 2003 Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 13: 3-126.
10. Melmed S, Geola FL, Reed, AW, et al, 1982 A comparison of methods for assessing thyroid function in nonthyroidal illness. J Clin Endocrinol Metab 54: 300-306.
11. Mebis L, Van den Berghe G, 2011 Thyroid axis function and dysfunction in critical illness. Best Pract Res Clin Endocrinol Metab 25: 745-757.
12. Slag MF, Morley JE, Elson MK, et al, 1981 Hypothyroxinemia in critically ill patients as a predictor of high mortality. JAMA 245: 43-45.
13. De Groot LJ, 2006 Non-thyroidal illness syndrome is a manifestation of hypothalamic-pituitary dysfunction, and in view of current evidence, should be treated with appropriate replacement therapies. Crit Care Clin 22: 57-86.
14. Amberson J, Drinka PJ, 1998 Medication and low serum thyroxine values in nursing home residents. South Med J 91: 437-440.
15. Iglesias P, Munoz A, Prado F, et al, 2010 Serum thyrotropin concentration is an early marker of normalization of low triiodothyronine syndrome in aged hospitalized patients after discharge. J Endocrinol Invest 33: 607-611.
16. Klein I, Danzi S, 2007 Thyroid disease and the heart. Circulation 116: 1725-1735.
17. I mberti R, Ferrari M, Albertini R, Rizzo V, Tinelli C, 2010 Increased levothyroxine requirements in critically ill patients with hypothyroidism. Minerva Anestesiol 76: 500-503.
18. Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR, 2009 High frequency of and factors associated with thyroid hormone over-replacement and underreplacement in men and women aged 65 and over. J Clin Endocrinol Metab 94: 1342-1345.