Does Toxoplasma gondii infection affect cognitive function? A case control study

Folia Parasitologica

Volumn 59, Issue 2, 2012, Pages 93-98

  Guenter, Wojciech ^a   Bieliński, Maciej ^a,b   Deptuła, Aleksander ^a   Zalas Wiecek, Patrycja ^a   Piskunowicz, Małgorzata ^a   Szwed, Krzysztof ^a   Buciński, Adam ^a   Gospodarek, Eugenia ^a   Borkowska, Alina ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b Division of Vascular Diseases and Internal Medicine   (Poland)

Author keywords

Cognitive function; Cognitive impairment; Latent toxoplasmosis; Neuropsychological tests; Toxoplasma gondii

Indexed keywords

TOXOPLASMA; TOXOPLASMA GONDII;

IMMUNOGLOBULIN G; PROTOZOON ANTIBODY;

ADULT; ARTICLE; BLOOD; CASE CONTROL STUDY; CHRONIC DISEASE; COGNITIVE DEFECT; FEMALE; HUMAN; MALE; MIDDLE AGED; PARASITOLOGY; TOXOPLASMA; TOXOPLASMOSIS;

ADULT; ANTIBODIES, PROTOZOAN; CASE-CONTROL STUDIES; CHRONIC DISEASE; COGNITION DISORDERS; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; TOXOPLASMA; TOXOPLASMOSIS; YOUNG ADULT;

EID: 84864839455     PISSN: 00155683     EISSN: 18036465     Source Type: Journal    
DOI: 10.14411/fp.2012.014     Document Type: Article

References (38)

1. Alford C.A. Jr., Stagno S., Reynolds D.W. 1974: Congenital toxoplasmosis: clinical laboratory and therapeutic considerations, with special reference to subclincial disease. Bull. N. Y. Acad. Med. 50: 160-181.
2. Blader I.J., Manger I.D., Boothroyd J.C. 2001: Microarray analysis reveals previously unknown changes in Toxoplasma gondii infected human cells. J. Biol. Chem. 276: 24223-24231.
3. Caiaffa W.T., Chiari C.A., Figueiredo A.R., Orefice F., Antunes C.M. 1993: Toxoplasmosis and mental retardation - report of a case-control study. Mem. Inst. Oswaldo Cruz 88: 253-261.
4. Cetinkaya Z., Yazar S., Gecici O., Namli M.N. 2007: Anti-Toxoplasma gondii antibodies in patients with schizophrenia - preliminary findings in a Turkish sample. Schizophr. Bull. 33: 789-791.
5. Cohen J. 1988: Statistical power analysis for the behavioral sciences. 2nd edition. L. Erlbaum Associates, Hillsdale, New Jersey, 567 pp.
6. Faul F., Erdfelder E., Lang A.G., Buchner A. 2007: G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39: 175-191.
7. Fekadu A., Shibre T., Cleare A.J. 2010: Toxoplasmosis as a cause for behaviour disorders - overview of evidence and mechanisms. Folia Parasitol. 57: 105-113.
8. Flegr J., Hrdý I. 1994: Influence of chronic toxoplasmosis on some human personality factors. Folia Parasitol. 41: 122-126.
9. Flegr J., Klose J., Novotná M., Berenreitterová M., Havlíček J. 2009: Increased incidence of traffic accidents in Toxoplasmainfected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study. BMC Infect. Dis. 9: e72.
10. Flegr J., Kodym P., Tolarová V. 2000: Correlation of duration of latent Toxoplasma gondii infection with personality changes in women. Biol. Psychol. 53: 57-68.
11. Flegr J., Novotná M., Fia lová A., Kolbeková P., Gašová Z. 2010: The influence of RhD phenotype on toxoplasmosis- and age-associated changes in personality profile of blood donors. Folia Parasitol. 57: 143-150.
12. Flegr J., Novotná M., Lindová J., Havlíček J. 2008: Neurophysiological effect of the Rh factor. Protective role of the RhD molecule against Toxoplasma-induced impairment of reaction times in women. Neuroendocrinol. Lett. 29: 475-481.
13. Flegr J., Preiss M., Klose J., Havlíček J., Vitáková M., Kodym P. 2003: Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii. Dopamine, a missing link between schizophrenia and toxoplasmosis? Biol. Psychol. 63: 253-268.
14. Havlíček J., Gašová Z.G., Smith A.P., Zvára K., Flegr J. 2001: Decrease of psychomotor performance in subjects with latent 'asymptomatic' toxoplasmosis. Parasitology 122: 515-520.
15. Hay J., Aitken P.P., Hutchison W.M., Graham D.I. 1983: The effect of congenital and adult-acquired Toxoplasma infections on activity and responsiveness to novel stimulation in mice. Ann. Trop. Med. Parasitol. 77: 483-495.
16. Hermes G., Ajioka J.W., Kelly K.A., Mui E., Roberts F., Kasza K., Mayr T., Kirisits M.J., Wollmann R., Ferguson D.J., Roberts C.W., Hwang J.H., Trendler T., Kennan R.P., Suzuki Y., Reardon C., Hickey W.F., Chen L., McLeod R. 2008: Neurological and behavioural abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J. Neuroinflammation 5: e48.
17. Jones J.L., Kruszon-Moran D., Sanders-Lewis K., Wilson M. 2007: Toxoplasma gondii infection in the United States, 1999-2004, decline from the prior decade. Am. J. Trop. Med. Hyg. 77: 405-410.
18. Kannan G., Moldovan K., Xiao J.C., Yolken R.H., Jones-Brando L., Pletnikov M.V. 2010: Toxoplasma gondii straindependent effects on mouse behaviour. Folia Parasitol. 57: 151-155.
19. Kehagia A.A., Murray G.K., Robbins T.W. 2010: Learning and cognitive flexibility: frontostriatal function and monoaminergic modulation. Curr. Opin. Neurobiol. 20: 199-204.
20. Lyons R.E., McLeod R., Roberts C.W. 2002: Toxoplasma gondii tachyzoite-bradyzoite interconversion. Trends Parasitol. 18: 198-201.
21. Markell E.K., John D.T., Krotoski W.A. 1999: Markell and Voge's Medical Parasitology. 8th edition. W.B. Saunders Company, Philadelphia, 501 pp.
22. Miman O., Mutlu E.A., Ozcan O., Atambay M., Karlidag R., Unal S. 2010: Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res. 177: 263-265.
23. Montoya J.G., Liesenfeld O. 2004: Toxoplasmosis. Lancet 363: 1965-1976.
24. Niemiec K.T., Raczyński P., Markiewicz K., Leibschang J., Ceran A. 2002: The prevalence of Toxoplasma gondii infection among 2016 pregnant women and their children in the Institute of Mother and Child in Warsaw. Wiad. Parazytol. 48: 293-299. (In Polish with English abstract.)
25. Novotná M., Havlíček J., Smith A.P., Kolbeková P., Skallová A., Klose J., Gašová Z., Písačka M., Sechovská M., Flegr J. 2008: Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology 135: 1253-1261.
26. Remington J.S., Krahenbuhl J.L. 1982: Immunology of Toxoplasma gondii. In: A.J. Nahmias and J. O'Reilly (Eds.), Immunology of Human Infection. Part II. Plenum Publishing Corporation, New York, pp. 327-371.
27. Schnider A., Guggisberg A., Nahum L., Gabriel D., Morand S. 2010: Dopaminergic modulation of rapid reality adaptation in thinking. Neuroscience 167: 583-587.
28. Skallová A., Kodym P., Frynta D., Flegr J. 2006: The role of dopamine in Toxoplasma-induced behavioural alterations in mice: an ethological and ethopharmacological study. Parasitology 133: 525-535.
29. Skallová A., Novotná M., Kolbeková P., Gašová Z., Veselý V., Sechovská M., Flegr J. 2005: Decreased level of novelty seeking in blood donors infected with Toxoplasma. Neuroendocrinol. Lett. 26: 480-486.
30. Stibbs H.H. 1985: Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Ann. Trop. Med. Parasitol. 79: 153-157.
31. Strauss E., Sherman E.M., Spreen O. 2006: A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. 3rd edition. Oxford University Press, Oxford, 1216 pp.
32. Tamer G.S., Dundar D., Yalug I., Caliskan S., Yazar S., Aker A. 2008: The schizophrenia and Toxoplasma gondii connection: infectious, immune or both? Adv. Ther. 25: 703-709.
33. Tenter A.M., Heckeroth A.R., Weiss L.M. 2000: Toxoplasma gondii: from animals to humans. Int. J. Parasitol. 30: 1217-1258.
34. Vyas A., Kim S.K., Giacomini N., Boothroyd J.C., Sapolsky R.M. 2007: Behavioural changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors. Proc. Natl. Acad. Sci. U.S.A. 104: 6442-6447.
35. Wang H.L., Wang G.H., Li Q.Y., Shu C., Jiang M.S., Guo Y. 2006: Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia. Acta Psychiatr. Scand. 114: 40-48.
36. Webster J.P., Brunton C.F., Macdonald D.W. 1994: Effect of Toxoplasma gondii on neophobic behaviour in wild brown rats, Rattus norvegicus. Parasitology 109: 37-43.
37. Witting P.A. 1979: Learning capacity and memory of normal and Toxoplasma-infected laboratory rats and mice. Z. Parasitenkd. 61: 29-51.
38. Yereli K., Balcioǧlu I.C., Ozbilgin A. 2006: Is Toxoplasma gondii a potential risk for traffic accidents in Turkey? Forensic Sci. Int. 163: 34-37.