Transcriptional profiling of microdissected areas of active multiple sclerosis lesions reveals activation of heat shock protein genes

Journal of Neuroscience Research

Volumn 90, Issue 10, 2012, Pages 1941-1948

  Mycko, Marcin P ^a   Brosnan, Celia F ^b   Raine, Cedric S ^b   Fendler, Wojciech ^a   Selmaj, Krzysztof W ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Heat shock proteins; Microarray analysis; Multiple sclerosis

Indexed keywords

ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEAT SHOCK FACTOR 4 GENE; HEAT SHOCK PROTEIN GENE; HUMAN; HUMAN TISSUE; LASER CAPTURE MICRODISSECTION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; UPREGULATION; WHITE MATTER;

AGED; AUTOPSY; BRAIN; COMPUTATIONAL BIOLOGY; DEMYELINATING DISEASES; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; HEAT-SHOCK PROTEINS; HUMANS; LASER CAPTURE MICRODISSECTION; MALE; MICROARRAY ANALYSIS; MULTIPLE SCLEROSIS; RNA; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84864838670     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23079     Document Type: Article

References (40)

1. Akerfelt M, Morimoto RI, Sistonen L. 2010. Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol 11: 545-555.
2. Alston MJ, Seers J, Hinton JC, Lucchini S. 2010. BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets. BMC Bioinformatics 11: 73.
3. Aquino DA, Capello E, Weisstein J, Sanders V, Lopez C, Tourtellotte WW, Brosnan CF, Raine CS, Norton WT. 1997. Multiple sclerosis: altered expression of 70- and 27-kDa heat shock proteins in lesions and myelin. J Neuropathol Exp Neurol 56: 664-672.
4. Brosnan CF, Cannella B, Battistini L, Raine CS. 1995. Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species. Neurology 45( Suppl 6): S16-S21.
5. Cannella B, Raine CS. 1995. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 37: 424-435.
6. Christians ES, Zhou Q, Renard J, Benjamin IJ. 2003. Heat shock proteins in mammalian development. Semin Cell Dev Biol 14: 283-290.
7. Cwiklinska H, Mycko MP, Luvsannorov O, Walkowiak B, Brosnan CF, Raine CS, Selmaj KW. 2003. Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains. Int Immunol 15: 241-249.
8. Cwiklinska H, Mycko MP, Szymanska B, Matysiak M, Selmaj KW. 2010. Aberrant stress-induced Hsp70 expression in immune cells in multiple sclerosis. J Neurosci Res 88: 3102-3110.
9. Frohman EM, Racke MK, Raine CS. 2006. Multiple sclerosis-the plaque and its pathogenesis. N Engl J Med 354: 942-955.
10. Fujimoto M, Nakai A. 2010. The heat shock factor family and adaptation to proteotoxic stress. FEBS J 277: 4112-4125.
11. Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. 2006. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle 5: 2592-2601.
12. Hageman J, Kampinga HH. 2009. Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library. Cell Stress Chaperones 14: 1-21.
13. + memory T cells. Eur J Immunol 35: 3163-3172.
14. Hauser SL, Oksenberg JR. 2006. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52: 61-76.
15. Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D. 2007. Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis 45: 487-501.
16. Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE. 2009. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 14: 105-111.
17. Lassmann H, Raine CS, Antel J, Prineas JW. 1998. Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol 86: 213-217.
18. Li Y, Li T, Liu S, Qiu M, Han Z, Jiang Z, Li R, Ying K, Xie Y, Mao Y. 2004. Systematic comparison of the fidelity of aRNA, mRNA and T-RNA on gene expression profiling using cDNA microarray. J Biotechnol 107: 19-28.
19. Li Z, Menoret A, Srivastava P. 2002. Roles of heat-shock proteins in antigen presentation and cross-presentation. Curr Opin Immunol 14: 45-51.
20. Liberzon A, Subramanian A, Pinchback R, Thorvaldsdottir H, Tamayo P, Mesirov JP. 2011. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27: 1739-1740.
21. Lund BT, Chakryan Y, Ashikian N, Mnatsakanyan L, Bevan CJ, Aguilera R, Gallaher T, Jakowec MW. 2006. Association of MBP peptides with Hsp70 in normal appearing human white matter. J Neurol Sci 249: 122-134.
22. Morimoto RI, Santoro MG. 1998. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat Biotechnol 16: 833-838.
23. Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW. 2003. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain 126: 1048-1057.
24. Mycko MP, Cwiklinska H, Szymanski J, Szymanska B, Kudla G, Kilianek L, Odyniec A, Brosnan CF, Selmaj KW. 2004a. Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II. J Immunol 172: 202-213.
25. Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW. 2004b. Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis. Clin Neurol Neurosurg 106: 223-229.
26. Mycko MP, Cwiklinska H, Walczak A, Libert C, Raine CS, Selmaj KW. 2008. A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen. Eur J Immunol 38: 1999-2013.
27. Panjwani N, Akbari O, Garcia S, Brazil M, Stockinger B. 1999. The HSC73 molecular chaperone: involvement in MHC class II antigen presentation. J Immunol 163: 1936-1942.
28. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. 1983. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13: 227-231.
29. Raine CS. 1994. The Dale E. McFarlin Memorial Lecture: the immunology of the multiple sclerosis lesion. Ann Neurol 36( Suppl): S61-S72.
30. Sahi C, Craig EA. 2007. Network of general and specialty J protein chaperones of the yeast cytosol. Proc Natl Acad Sci U S A 104: 7163-7168.
31. Somasundaram T, Bhat SP. 2004. Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. J Biol Chem 279: 44497-44503.
32. Srivastava P. 2002. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2: 185-194.
33. Stahnke T, Stadelmann C, Netzler A, Bruck W, Richter-Landsberg C. 2007. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J Mol Neurosci 32: 25-37.
34. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
35. + T cells. J Immunol 173: 5130-5137.
36. Wang R, Kovalchin JT, Muhlenkamp P, Chandawarkar RY. 2006. Exogenous heat shock protein 70 binds macrophage lipid raft microdomain and stimulates phagocytosis, processing, and MHC-II presentation of antigens. Blood 107: 1636-1642.
37. Westerheide SD, Morimoto RI. 2005. Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem 280: 33097-33100.
38. Williams A, Piaton G, Lubetzki C. 2007. Astrocytes-friends or foes in multiple sclerosis? Glia 55: 1300-1312.
39. Yoshima T, Yura T, Yanagi H. 1998. Novel testis-specific protein that interacts with heat shock factor 2. Gene 214: 139-146.
40. Zietara N, Lyszkiewicz M, Gekara N, Puchalka J, Dos Santos VA, Hunt CR, Pandita TK, Lienenklaus S, Weiss S. 2009. Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol 183: 1099-1109.