Clinical relevance of sirolimus drug interactions in transplant patients

Transplantation Proceedings

Volumn 36, Issue 10, 2004, Pages 3226-3228

  Sádaba, Belen ^a   Campanero, M A ^a   Quetglas, E G ^a   Azanza, J R ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CYTOCHROME P450; ERYTHROMYCIN; FLUCONAZOLE; ITRACONAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RAPAMYCIN; TACROLIMUS; VORICONAZOLE; ANTIFUNGAL AGENT; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; IMMUNOSUPPRESSIVE AGENT; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; ASPERGILLOSIS; BASAL CELL CARCINOMA; CANDIDIASIS; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HEART TRANSPLANTATION; HUMAN; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; LUNG CARCINOMA; MALE; MYCOSIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; SQUAMOUS CELL CARCINOMA; BIOTRANSFORMATION; CASE REPORT; DRUG INTERACTION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

AGED; ANTIFUNGAL AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; PYRIMIDINES; SIROLIMUS; TRIAZOLES;

EID: 21244467947     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2004.10.056     Document Type: Article

References (8)

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3. Zimmerman JJ, Harper D, Getsy J, et al: Pharmacokinetic interactions between sirolimus and microemulsion cyclosporine when orally administered jointly and 4 hours apart in healthy volunteers. J Clin Pharmacol 43:1168, 2003
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5. Cervelli MJ: Fluconazole-sirolimus drug interaction. Transplantation 74:1477, 2002
6. Bottiger Y, Sawe J, Brattstrom C, et al: Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers. Clin Pharmacol Ther 69:32, 2001
7. Fridell JA, Jain AK, Patel K, et al: Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report. Ther Drug Monit 25:117, 2003
8. Campanero MA, Cardenas E, Sadaba B, et al: Therapeutic drug monitoring for sirolimus in whole blood of organ transplants by high-performance liquid chromatography with ultraviolet detection: J Chromatogr A 1031:265, 2004