An update on phthalates and male reproductive development and function

Current Urology Reports

Volumn 13, Issue 4, 2012, Pages 307-310

  Grady, Richard ^a   Sathyanarayana, Sheela ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Anogenital distance; Birth anomalies; Cryptorchism; Endocrine disruptor; Genitourinary tract; Hypospadias; Infertility; Phthalates; Subfertility; Testis anomalies

Indexed keywords

TESTOSTERONE;

ARTICLE; HEALTH HAZARD; HUMAN; MALE FERTILITY; MALE GENITAL SYSTEM FUNCTION; MALE GENITAL TRACT MALFORMATION; MALE INFERTILITY; NONHUMAN; PENILE SIZE; PRENATAL EXPOSURE; REPRODUCTIVE HEALTH; SEMEN ANALYSIS; SPERMATOZOON MOTILITY; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS; UROGENITAL SYSTEM PARAMETERS;

ANIMALS; CRYPTORCHIDISM; ENDOCRINE DISRUPTORS; HUMANS; HYPOSPADIAS; INFERTILITY, MALE; MALE; PHTHALIC ACIDS; UROGENITAL ABNORMALITIES;

EID: 84864831047     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-012-0261-1     Document Type: Article

References (33)

1. CDC, Third national report on human exposure to environmental chemicals: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences: Atlanta, GA; 2005.
2. Hauser R, et al. Medications as a source of human exposure to phthalates. Environ Health Perspect. 2004;112(6):751-3.
3. Rudel RA, et al. Phthalates, alkylphenols, pesticides, polybromi-nated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Environ Sci Technol. 2003;37(20):4543-53.
4. Rudel RA, et al. Phthalates, alkylphenols, pesticides, polybromi-nated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Environ Sci Technol. 2003;37(20):4543-53.
5. Wormuth M, et al. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Risk Anal. 2006;26(3):803-24.
6. Swan SH. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008;108(2):177-84.
7. Main KM, et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Heal Perspect. 2006;114(2):270-6.
8. Huang PC, et al. Association between prenatal exposure to phtha-lates and the health of newborns. Environ Int. 2008.
9. Akingbemi BT, et al. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. PNAS. 2004;101 (3):775-80.
10. Borch J, et al. Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. Reprod Toxicol. 2004;18:53-61.
11. Foster PM, Cattley RC, Mylchreest E. Effects of di-n-butyl phtha-late (DBP) on male reproductive development in the rat: implications for human risk assessment. Food Chem Toxicol. 2000;38 Suppl 1:S97-9 Review 16 refs.
12. Mylchreest E, Foster PM. DBP exerts its antiandrogenic activity by indirectly interfering with androgen signaling pathways. Tox-icol Appl Pharmacol. 2000;168(2):174-5.
13. Wohlfahrt-Veje C, Main KM, Skakkebaek NE. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems. Clin Endocrinol (Oxf). 2009;71(4):459-65.
14. Wilson VS, et al. Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development. Int J Androl. 2008;31(2):178-87.
15. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect. 2000;108(10):961-6.
16. Duty SM, et al. Phthalate exposure and human semen parameters. Epidemiology. 2003;14(3):269-77.
17. Latini G, et al. Phthalate exposure and male infertility. Toxicology. 2006;226(2-3):90-8.
18. Lamb JCT, et al. Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol. 1987;88(2):255-69.
19. Gray Jr LE, et al. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350-65.
20. Lee BM, Koo HJ. Hershberger assay for antiandrogenic effects of phthalates. J Toxicol Environ Heal. 2007;70:1365-70.
21. Foster PM. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 2006;29(1):140-7.
22. Gray LE, et al. Use of the laboratory rat as a model in endocrine disruptor screening and testing. ILAR J Nat Res Council Instit Lab Anima Resou. 2004;45(4):425-37.
23. Hotchkiss AK, et al. Androgens and environmental antiandrogens affect reproductive development and play behavior in the Sprague-Dawley rat. Environ Health Perspect. 2002;110 Suppl 3:435-9.
24. Pant N, et al. Environmental and experimental exposure of phthalate esters: the toxicological consequence on human sperm. Hum Exp Toxicol. 2011;30(6):507-14.
25. Hsieh MH, et al. Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption. Curr Urol Rep. 2008;9(2):137-42.
26. Swan SH, et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Heal Perspect. 2005;113(8):1056-61.
27. Howdeshell KL, et al. A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague Dawley rat in a cumulative, dose additive manner. Toxicol Sci. 2008.
28. Huang PC, et al. Association between prenatal exposure to phthalates and the health of newborns. Environ Int. 2009;35(1):14-20.
29. Meeker JD, Calafat AM, Hauser R. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl. 2009;30(3):287-97.
30. Tranfo G, et al. Urinary phthalate monoesters concentration in couples with infertility problems. Toxicol Lett. 2011.
31. Arbuckle TE, et al. Meeting report: measuring endocrine-sensitive endpoints within the first years of life. Environ Health Perspect. 2008;116(7):948-51.
32. Mendiola J, et al. Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York. Environ Health Perspect. 2011;119(7):958-63.
33. Eisenberg ML, et al. The relationship between anogenital distance and the efficacy of varicocele repair. BJU Int. 2012.