Wnt3a expression during the differentiation of adipose-derived stem cells into cholinergic neurons

Neural Regeneration Research

Volumn 7, Issue 19, 2012, Pages 1463-1468

  Liu, Bin ^a   Deng, Chunying ^a   Zhang, Yuqin ^a   Zhang, Jinxia ^a  

^a HEBEI UNITED UNIVERSITY   (China)

Author keywords

Adipose derived stem cells; Cholinergic neurons; Differentiation; Induction; Neural regeneration; Neural stem cells; Wnt3a

Indexed keywords

CHOLINE ACETYLTRANSFERASE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; NEURON SPECIFIC ENOLASE; WNT3A PROTEIN;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MALE; NERVE CELL DIFFERENTIATION; NONHUMAN; OBSERVATIONAL STUDY; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84864817431     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.19.003     Document Type: Article

References (16)

1. Wexler EM, Geschwind DH, Palmer TD. Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Mol Psychiatry. 2008; 13(3):285-292.
2. Alfieri CM, Cheek J, Chakraborty S, et al. Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol. 2010;338(2):127-135.
3. Lyubimova A, Garber JJ, Upadhyay G, et al. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest. 2010;120(2):446-456.
4. Muroyama Y, Kondoh H, Takada S. Wnt proteins promote neuronal differentiation in neural stem cell culture. Biochem Biophys Res Commun. 2004;313(4):915-921.
5. Liu B, Wu MH, Zhang Q, et al. The expression of tyrosine hydroxylase choline acetyl transferase glutamic acid decarboxylase of human adipose tissue-derived stromal cells into neural cells. Zhongguo Kangfu Yixue Zazhi. 2007;22(8):691-701.
6. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007;100(9): 1249-1260.
7. Wang F, Chen H, Sun X. Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice. Neurosci Lett. 2009;454(3):212-217.
8. Ille F, Sommer L. Wnt signaling: multiple functions in neural development. Cell Mol Life Sci. 2005;62(10): 1100-1108.
9. Nemeth MJ, Topol L, Anderson SM, et al. Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Natl Acad Sci U S A. 2007;104(39):15436-15441.
10. Zhou H, Mak W, Yu Z, et al. Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling. J Biol Chem. 2008;283(4): 1936-1945.
11. Daneman R, Agalliu D, Zhou L. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009;106(2): 641-646.
12. Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem. 2006;281(32):22429-22433.
13. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
14. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211-228.
15. Dobashi Y, Kudoh T, Matsumine A, et al. Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells. J Biol Chem. 1995; 270(39):23031-23037.
16. Dong Y, Cao J, Wang H, et al. Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to alpha-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor. Biochem Biophys Res Commun. 2010;396(4):849-853.